Search Results - "MacKay, R"

CHOICE, CHANCE, AND UNINTENDED CONSEQUENCES IN STRATEGIC CHANGE: A PROCESS UNDERSTANDING OF THE RISE AND FALL OF NORTHCO AUTOMOTIVE by MacKAY, R. BRADLEY, CHIA, ROBERT

“…Strategic change is frequently viewed as emanating from the purposeful choices of organizational actors intent on achieving a prespecified goal against a…”
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The nutrition‐gut microbiome‐physiology axis and allergic diseases by McKenzie, Craig, Tan, Jian, Macia, Laurence, Mackay, Charles R.

“…Summary Dietary and bacterial metabolites influence immune responses. This raises the question whether the increased incidence of allergies, asthma, some…”
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Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways by Tan, Jian, McKenzie, Craig, Vuillermin, Peter J., Goverse, Gera, Vinuesa, Carola G., Mebius, Reina E., Macia, Laurence, Mackay, Charles R.

“…The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103+…”
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The role of short-chain fatty acids in health and disease by Tan, Jian, McKenzie, Craig, Potamitis, Maria, Thorburn, Alison N, Mackay, Charles R, Macia, Laurence

“…There is now an abundance of evidence to show that short-chain fatty acids (SCFAs) play an important role in the maintenance of health and the development of…”
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Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation by Tan, Jian K, McKenzie, Craig, Mariño, Eliana, Macia, Laurence, Mackay, Charles R

“…Nutrition and the gut microbiome regulate many systems, including the immune, metabolic, and nervous systems. We propose that the host responds to deficiency…”
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Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid-Mediated Activation of G Protein-Coupled Receptors GPR43 and GPR109A by Li, Yan Jun, Chen, Xiaochen, Kwan, Tony K, Loh, Yik Wen, Singer, Julian, Liu, Yunzi, Ma, Jin, Tan, Jian, Macia, Laurence, Mackay, Charles R, Chadban, Steven J, Wu, Huiling

“…Studies have reported "dysbiotic" changes to gut microbiota, such as depletion of gut bacteria that produce short-chain fatty acids (SCFAs) through gut…”
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High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice by Marques, Francine Z, Nelson, Erin, Chu, Po-Yin, Horlock, Duncan, Fiedler, April, Ziemann, Mark, Tan, Jian K, Kuruppu, Sanjaya, Rajapakse, Niwanthi W, El-Osta, Assam, Mackay, Charles R, Kaye, David M

“…BACKGROUND:Dietary intake of fruit and vegetables is associated with lower incidence of hypertension, but the mechanisms involved have not been elucidated…”
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Use of Stokes’ theorem for plasma confinement by MacKay, R. S.

“…Stokes’ theorem, in its original form and Cartan’s generalization, is crucial for designing magnetic fields to confine plasma (ionized gas). The paper…”
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Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications by Whitmore, L., Mackay, R. I., van Herk, M., Jones, J. K., Jones, R. M.

“…This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets…”
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Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease by Kaye, David M., Shihata, Waled A., Jama, Hamdi A., Tsyganov, Kirill, Ziemann, Mark, Kiriazis, Helen, Horlock, Duncan, Vijay, Amrita, Giam, Beverly, Vinh, Antony, Johnson, Chad, Fiedler, April, Donner, Daniel, Snelson, Matthew, Coughlan, Melinda T., Phillips, Sarah, Du, Xiao-Jun, El-Osta, Assam, Drummond, Grant, Lambert, Gavin W., Spector, Tim D., Valdes, Ana M., Mackay, Charles R., Marques, Francine Z.

“…BACKGROUND:High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle…”
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Image Guidance for Proton Therapy by MacKay, R.I.

“…Image-guided radiotherapy has an established role in all forms of radiotherapy treatment delivery. Proton therapy seeks to deliver superior dose distributions…”
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Local area inspection: Arbitrary administrative rules by Mackay, R.

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Ten simple rules for supporting a temporary online pivot in higher education by Nordmann, Emily, Horlin, Chiara, Hutchison, Jacqui, Murray, Jo-Anne, Robson, Louise, Seery, Michael K, MacKay, Jill R D

“…As continued COVID-19 disruption looks likely across the world, perhaps until 2021, contingency plans are evolving in case of further disruption in the…”
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The performativity of strategic foresight tools: Horizon scanning as an activation device in strategy formation within a UK financial institution by Idoko, Onyaglanu, MacKay, R. Bradley

“…•Strategic foresight tools are frequently portrayed as instrumental and passive.•We show that tools such as the Horizon Scan can also be…”
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CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications by Whitmore, L., Mackay, R. I., van Herk, M., Korysko, P., Farabolini, W., Malyzhenkov, A., Corsini, R., Jones, R. M.

“…Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability…”
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Determining the parameter space for effective oxygen depletion for FLASH radiation therapy by Rothwell, B C, Kirkby, N F, Merchant, M J, Chadwick, A L, Lowe, M, Mackay, R I, Hendry, J H, Kirkby, K J

“…There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate…”
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Impacts of nonuniform flow on estimates of vertical streambed flux by Cuthbert, M. O., Mackay, R.

“…Key Points Non‐uniform flow fields cause errors in 1D heat tracer flux estimation methods Non‐vertical flow won't necessarily cause such errors Non‐uniform…”
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Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis by Koupenova, Milka, Vitseva, Olga, MacKay, Christopher R., Beaulieu, Lea M., Benjamin, Emelia J., Mick, Eric, Kurt-Jones, Evelyn A., Ravid, Katya, Freedman, Jane E.

“…Viral infections have been associated with reduced platelet counts, the biological significance of which has remained elusive. Here, we show that infection…”
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Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells by Goverse, Gera, Molenaar, Rosalie, Macia, Laurence, Tan, Jian, Erkelens, Martje N, Konijn, Tanja, Knippenberg, Marlene, Cook, Emma C L, Hanekamp, Diana, Veldhoen, Marc, Hartog, Anita, Roeselers, Guus, Mackay, Charles R, Mebius, Reina E

“…The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune…”
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Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses by Gatto, Dominique, Paus, Didrik, Basten, Antony, Mackay, Charles R., Brink, Robert

“…Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct…”
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