Search Results - "MacKay, C. F."

The Genetic Architecture of Quantitative Traits Cannot Be Inferred from Variance Component Analysis by Huang, Wen, Mackay, Trudy F C

“…Classical quantitative genetic analyses estimate additive and non-additive genetic and environmental components of variance from phenotypes of related…”
Get full text

The genetics of quantitative traits: challenges and prospects by Mackay, Trudy F. C, Stone, Eric A, Ayroles, Julien F

“…Key Points Most phenotypic variation in natural populations is attributable to multiple interacting loci, with allelic effects that are sensitive to the exact…”
Get full text

The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster by Hunter, Chad M, Huang, Wen, Mackay, Trudy F C, Singh, Nadia D

“…Meiotic recombination ensures proper chromosome segregation in many sexually reproducing organisms. Despite this crucial function, rates of recombination are…”
Get full text

Gregor Mendel's legacy in quantitative genetics by Mackay, Trudy F C, Anholt, Robert R H

“…Gregor Mendel's discovery of the laws of segregation and independent assortment and his inference of the existence of non-mendelian interactions between loci…”
Get full text

Quantitative Genetics of Food Intake in Drosophila melanogaster by Garlapow, Megan E, Huang, Wen, Yarboro, Michael T, Peterson, Kara R, Mackay, Trudy F C

“…Food intake is an essential animal activity, regulated by neural circuits that motivate food localization, evaluate nutritional content and acceptance or…”
Get full text

Using whole-genome sequence data to predict quantitative trait phenotypes in Drosophila melanogaster by Ober, Ulrike, Ayroles, Julien F, Stone, Eric A, Richards, Stephen, Zhu, Dianhui, Gibbs, Richard A, Stricker, Christian, Gianola, Daniel, Schlather, Martin, Mackay, Trudy F C, Simianer, Henner

“…Predicting organismal phenotypes from genotype data is important for plant and animal breeding, medicine, and evolutionary biology. Genomic-based phenotype…”
Get full text

Context-dependent genetic architecture of Drosophila life span by Huang, Wen, Campbell, Terry, Carbone, Mary Anna, Jones, W Elizabeth, Unselt, Desiree, Anholt, Robert R H, Mackay, Trudy F C

“…Understanding the genetic basis of variation in life span is a major challenge that is difficult to address in human populations. Evolutionary theory predicts…”
Get full text

Epistasis dominates the genetic architecture of Drosophila quantitative traits by Huang, Wen, Richards, Stephen, Carbone, Mary Anna, Zhu, Dianhui, Anholt, Robert R. H, Ayroles, Julien F, Duncan, Laura, Jordan, Katherine W, Lawrence, Faye, Magwire, Michael M, Warner, Crystal B, Blankenburg, Kerstin, Han, Yi, Javaid, Mehwish, Jayaseelan, Joy, Jhangiani, Shalini N, Muzny, Donna, Ongeri, Fiona, Perales, Lora, Wu, Yuan-Qing, Zhang, Yiqing, Zou, Xiaoyan, Stone, Eric A, Gibbs, Richard A, Mackay, Trudy F. C

“…Epistasis—nonlinear genetic interactions between polymorphic loci—is the genetic basis of canalization and speciation, and epistatic interactions can be used…”
Get full text

Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster by Highfill, Chad A, Baker, Brandon M, Stevens, Stephenie D, Anholt, Robert R H, Mackay, Trudy F C

“…Illicit use of psychostimulants, such as cocaine and methamphetamine, constitutes a significant public health problem. Whereas neural mechanisms that mediate…”
Get full text

Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster by Weber, Allison L, Khan, George F, Magwire, Michael M, Tabor, Crystal L, Mackay, Trudy F C, Anholt, Robert R H

“…Aerobic organisms are susceptible to damage by reactive oxygen species. Oxidative stress resistance is a quantitative trait with population variation…”
Get full text

Genome-wide association study of sleep in Drosophila melanogaster by Harbison, Susan T, McCoy, Lenovia J, Mackay, Trudy F C

“…Sleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of…”
Get full text

Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster by Dembeck, Lauren M, Huang, Wen, Magwire, Michael M, Lawrence, Faye, Lyman, Richard F, Mackay, Trudy F C

“…Pigmentation varies within and between species and is often adaptive. The amount of pigmentation on the abdomen of Drosophila melanogaster is a relatively…”
Get full text

Modulation of the Drosophila transcriptome by developmental exposure to alcohol by Morozova, Tatiana V, Shankar, Vijay, MacPherson, Rebecca A, Mackay, Trudy F C, Anholt, Robert R H

“…Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent, preventable pediatric disorder. Identifying genetic risk alleles…”
Get full text

Physiological and metabolomic consequences of reduced expression of the Drosophila brummer triglyceride Lipase by Nazario-Yepiz, Nestor O, Fernández Sobaberas, Jaime, Lyman, Roberta, Campbell, 3rd, Marion R, Shankar, Vijay, Anholt, Robert R H, Mackay, Trudy F C

“…Disruption of lipolysis has widespread effects on intermediary metabolism and organismal phenotypes. Defects in lipolysis can be modeled in Drosophila…”
Get full text

Quantitative genomics of aggressive behavior in Drosophila melanogaster by Edwards, Alexis C, Rollmann, Stephanie M, Morgan, Theodore J, Mackay, Trudy F C

“…Aggressive behavior is important for animal survival and reproduction, and excessive aggression is an enormous social and economic burden for human society…”
Get full text

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure by Zhou, Shanshan, Luoma, Sarah E, St Armour, Genevieve E, Thakkar, Esha, Mackay, Trudy F C, Anholt, Robert R H

“…The genetic factors that give rise to variation in susceptibility to environmental toxins remain largely unexplored. Studies on genetic variation in…”
Get full text

Phenotypic plasticity of the Drosophila transcriptome by Zhou, Shanshan, Campbell, Terry G, Stone, Eric A, Mackay, Trudy F C, Anholt, Robert R H

“…Phenotypic plasticity is the ability of a single genotype to produce different phenotypes in response to changing environments. We assessed variation in…”
Get full text

THE GENETIC ARCHITECTURE OF QUANTITATIVE TRAITS by Mackay, Trudy F. C

“…Phenotypic variation for quantitative traits results from the segregation of alleles at multiple quantitative trait loci (QTL) with effects that are sensitive…”
Get full text

Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait by Ober, Ulrike, Huang, Wen, Magwire, Michael, Schlather, Martin, Simianer, Henner, Mackay, Trudy F C

“…The ability to predict quantitative trait phenotypes from molecular polymorphism data will revolutionize evolutionary biology, medicine and human biology, and…”
Get full text

Pleiotropic fitness effects of the lncRNA Uhg4 in Drosophila melanogaster by MacPherson, Rebecca A, Shankar, Vijay, Sunkara, Lakshmi T, Hannah, Rachel C, Campbell, 3rd, Marion R, Anholt, Robert R H, Mackay, Trudy F C

“…Long noncoding RNAs (lncRNAs) are a diverse class of RNAs that are critical for gene regulation, DNA repair, and splicing, and have been implicated in…”
Get full text