Search Results - "MacKay, A L"

Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology by Laule, C, Leung, E, Li, D KB, Traboulsee, A L, Paty, D W, MacKay, A L, Moore, G RW

“…Various magnetic resonance (MR) techniques are used to study the pathological evolution of demyelinating diseases, such as multiple sclerosis (MS). However,…”
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Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease by STURROCK, A, LAULE, C, MACKAY, A. L, LEAVITT, B. R, DECOLONGON, J, DAR SANTOS, R, COLEMAN, A. J, CREIGHTON, S, BECHTEL, N, REILMANN, R, HAYDEN, M. R, TABRIZI, S. J

“…To evaluate in vivo brain metabolite differences in control subjects, individuals with premanifest Huntington disease (pre-HD), and individuals with early HD…”
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Non‐negative least squares computation for in vivo myelin mapping using simulated multi‐echo spin‐echo T2 decay data by Wiggermann, V., Vavasour, I.M., Kolind, S.H., MacKay, A.L., Helms, G., Rauscher, A.

“…Multi‐compartment T2 mapping has gained particular relevance for the study of myelin water in the brain. As a facilitator of rapid saltatory axonal signal…”
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Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins by FLYNN, S. W, LANG, D. J, FALKAI, P, HONER, W. G, MACKAY, A. L, GOGHARI, V, VAVASOUR, I. M, WHITTALL, K. P, SMITH, G. N, ARANGO, V, MANN, J. J, DWORK, A. J

“…Schizophrenia unfolds during the late period of brain maturation, while myelination is still continuing. In the present study, we used MRI and T2 relaxation…”
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Multiple measures of corticospinal excitability are associated with clinical features of multiple sclerosis by Neva, J.L., Lakhani, B., Brown, K.E., Wadden, K.P., Mang, C.S., Ledwell, N.H.M., Borich, M.R., Vavasour, I.M., Laule, C., Traboulsee, A.L., MacKay, A.L., Boyd, L.A.

“…•Corticospinal excitability and inhibition are altered in individuals with MS.•Cortical and interhemispheric excitability accounts for unique variance in…”
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Two-year study of cervical cord volume and myelin water in primary progressive multiple sclerosis by Laule, C., Vavasour, IM, Zhao, Y., Traboulsee, AL, Oger, J., Vavasour, JD, Mackay, AL, Li, DKB

“…Background: Spinal cord involvement in multiple sclerosis (MS) is common and an important element in disability. Previous studies demonstrated smaller cervical…”
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Longitudinal changes in myelin water fraction in two MS patients with active disease by Vavasour, I.M, Laule, C, Li, D.K.B, Oger, J, Moore, G.R.W, Traboulsee, A, MacKay, A.L

“…Abstract Multiple sclerosis (MS) is characterised by focal areas that undergo cycles of demyelination and remyelination. Although conventional magnetic…”
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Characterization of the NMR behavior of white matter in bovine brain by Bjarnason, T.A., Vavasour, I.M., Chia, C.L.L., MacKay, A.L.

“…In vitro experiments on 15 white matter samples from five bovine brains were performed on a 1H‐NMR spectrometer at 24°C and 37°C. The average myelin water…”
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A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain by MOORE, G. R. W, LEUNG, E, PATY, D. W, MACKAY, A. L, VAVASOUR, I. M, WHITTALL, K. P, COVER, K. S, LI, D. K. B, HASHIMOTO, S. A, OGER, J, SPRINKLE, T. J

“…To determine the pathologic basis of areas not exhibiting signal of the short-T2 component of the T2 relaxation distribution in MS, as studied in…”
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Systematic enumeration of crystalline networks by Klinowski, Jacek, Friedrichs, Olaf Delgado, Dress, Andreas W. M, Huson, Daniel H, Mackay, Alan L

“…The systematic enumeration of all possible networks of atoms ininorganic structures is of considerable interest. Of particular importance are the 4-connected…”
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Diamond from graphite by MACKAY, A. L, TERRONES, H

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Cellular automata and local order in the structural chemistry of the lovozerite group minerals by Shevchenko, V. Ya, Krivovichev, S. V., Mackay, A. L.

“…The structural chemistry of the lovozerite group of minerals is considered using concepts of coordination polyhedra, finite automata and local order. A formal…”
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Evaluation of white matter myelin water fraction in chronic stroke by Borich, M R, Mackay, A L, Vavasour, I M, Rauscher, A, Boyd, L A

“…Multi-component T2 relaxation imaging (MCRI) provides specific in vivo measurement of myelin water content and tissue water environments through myelin water…”
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A comparison between magnetization transfer ratios and myelin water percentages in normals and multiple sclerosis patients by Vavasour, I M, Whittall, K P, MacKay, A L, Li, D K, Vorobeychik, G, Paty, D W

“…Magnetization transfer and T2 relaxation data were obtained for five white and six gray matter brain structures from 10 normal volunteers and 9 multiple…”
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A generalized model for the shell structure of icosahedral viruses by Shevchenko, V. Ya, Madison, A. E., Mackay, A. L.

“…The principles of algebraic geometry have been applied for the modelling of substances of different natures. A local packing approach provides a tool for…”
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In vivo measurement of T2 distributions and water contents in normal human brain by Whittall, K P, MacKay, A L, Graeb, D A, Nugent, R A, Li, D K, Paty, D W

“…Using a 32-echo imaging pulse sequence, T2 relaxation decay curves were acquired from five white- and six gray-matter brain structures outlined in 12 normal…”
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Evolution of focal and diffuse magnetisation transfer abnormalities in multiple sclerosis by Laule, Cornelia, Vavasour, Irene M, Whittall, Kenneth P, Oger, Joel, Paty, Donald W, Li, David K B, MacKay, Alex L, Arnold, Douglas L

“…Magnetisation transfer (MT) imaging provides indirect information on tissue structure abnormalities in areas that otherwise may appear normal on conventional…”
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Long T2 water in multiple sclerosis : What else can we learn from multi-echo T2 relaxation? by LAULE, Cornelia, VAVASOUR, Irene M, KOLIND, Shannon H, TRABOULSEE, Anthony L, MOORE, G. R. Wayne, LI, David K. B, MACKAY, Alex L

“…Multi-echo T(2) measurements are invaluable in studying brain pathology in multiple sclerosis (MS). In addition to information about myelin water and total…”
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MR Relaxation in Multiple Sclerosis by MacKay, A.L., DPhil, Vavasour, I.M., PhD, Rauscher, A., PhD, Kolind, S.H., MSc, Mädler, B., PhD, Moore, G.R.W., MD, Traboulsee, A.L., MD, Li, D.K.B., MD, Laule, C., PhD

“…This article provides an overview of relaxation times and their application to normal brain and brain and cord affected by multiple sclerosis. The goal is to…”
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Proton MRS of large multiple sclerosis lesions reveals subtle changes in metabolite T1 and area by Brief, E. E., Vavasour, I. M., Laule, C., Li, D. K. B., MacKay, A. L.

“…The T1 values of metabolites were measured in eight subjects with clinically definite multiple sclerosis (MS) having at least one large brain lesion (2.6 ± 0.7…”
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