Search Results - "MacHugh, N D"

Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function by Houston, E. Fiona, Taracha, E.L., Brackenbury, Louise, MacHugh, N.D., McKeever, D.J., Charleston, B., Morrison, W.I.

“…Theileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2–3 weeks of infection…”
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A rapid and sensitive intracellular flow cytometric assay to identify Theileria parva infection within target cells by Rocchi, M S, Ballingall, K T, Ngugi, D, MacHugh, N D, McKeever, D J

“…Theileria parva is an intracellular protozoan parasite transmitted by ticks that causes a fatal lymphoproliferative disease of cattle known as East Coast…”
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Variation in the number of expressed MHC genes in different cattle class I haplotypes by Ellis, S A, Holmes, E C, Staines, K A, Smith, K B, Stear, M J, McKeever, D J, MacHugh, N D, Morrison, W I

“…Analysis of cattle major histocompatibility complex (MHC) (BoLA) class I gene expression using serological and biochemical methods has demonstrated a high…”
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Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding efferent lymph by McKeever, D.J, Taracha, E.L.N, Innes, E.L, MacHugh, N.D, Awino, E, Goddeeris, B.M, Morrison, W.I

“…Evidence that class I major histocompatibility complex-restricted cytotoxic T lymphocytes (CTL) are involved in immunity to malaria has highlighted the…”
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Analysis of T-cell receptor BV gene sequences in cattle reveals extensive duplication within the BV9 and BV20 subgroups by Houston, E F, Connelley, T, Parsons, K, MacHugh, N D, Morrison, W I

“…We investigated the repertoire of functional T-cell receptor beta-chain variable genes (TRBV genes) in cattle by analysing the nucleotide sequences and…”
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Demonstration of strain‐specific CD8 T cell responses to Theileria annulata by MACHUGH, N. D., BURRELLS, A. C., MORRISON, W. I.

“…SUMMARY The present study set out to examine the nature and specificity of the bovine CD8 T cell response at the clonal level in a group of eight animals…”
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Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite by Morrison, W.I. (Institute for Animal Health, Compton, UK.), MacHugh, N.D, Lalor, P.A

“…Theileria parva has been shown to infect and transform B cells and T cells at similar frequencies in vitro. However, the majority of parasitized cells in the…”
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Characterization of a subset of bovine T lymphocytes that express BoT4 by monoclonal antibodies and function: similarity to lymphocytes defined by human T4 and murine L3T4 by Baldwin, CL, Teale, AJ, Naessens, JG, Goddeeris, BM, MacHugh, ND, Morrison, WI

“…We report the identification of a subset of bovine T cells by two monoclonal antibodies (mAb), IL-A11 and IL-A12, and some functional analyses of these cells…”
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CD45RO expression on bovine T cells: relation to biological function by Bembridge, G P, MacHugh, N D, McKeever, D, Awino, E, Sopp, P, Collins, R A, Gelder, K I, Howard, C J

“…The 180,000 MW isoform of CD45 (CD45RO) has been identified in cattle with a novel monoclonal antibody (mAb) (IL-A116). This has allowed a more precise…”
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Bovine T cells, B cells, and null cells are transformed by the protozoan parasite Theileria parva by BALDWIN, C. L, BLACK, S. J, NAESSENS, J, NEWSON, J, BROWN, W. C, CONRAD, P. A, GODDEERIS, B. M, KINUTHIA, S. W, LALOR, P. A, MACHUGH, N. D, MORRISON, W. I, MORZARIA, S. P

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of a monoclonal antibody reactive with the bovine orthologue of CD3 (BoCD3) by Davis, W C, MacHugh, N D, Park, Y H, Hamilton, M J, Wyatt, C R

“…A monoclonal antibody (mAb), MM1A, that identifies a molecule expressed on a large percentage of bovine lymphocytes (60-80%) was examined to determine its…”
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A highly sensitive, non-radioactive assay for T cell activation in cattle: applications in screening for antigens recognised by CD4 + and CD8 + T cells by Ballingall, Keith T., Mwangi, Duncan M., MacHugh, Niall D., Taracha, Evans L.N., Totte, Philippe, McKeever, Declan J.

“…We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative…”
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Recombinant bovine interferon gamma inhibits the growth of Cowdria ruminantium but fails to induce major histocompatibility complex class II following infection of endothelial cells by Totté, Ph, Vachiery, N., Martinez, D., Trap, I., Ballingall, K.T., MacHugh, N.D., Bensaid, A., Wérenne, J.

“…Recombinant bovine IFNγ is a potent inhibitor of Cowdria ruminantium growth in vitro irrespective of the rickettsial stock, or the origin of the endothelial…”
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Characterization by a monoclonal antibody and functional analysis of a subset of bovine T lymphocytes that express BoT8, a molecule analogous to human CD8 by ELLIS, J, BALDWIN, C. L, MACHUGH, N. D, BENSAID, A, TEALE, A. J, GODDEERIS, B. M

“…Monoclonal antibody (mAb) IL-A17 characterizes a subset of bovine T lymphocytes. IL-A17 recognizes a 34,000-35,000 MW doublet, designated BoT8, which is…”
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Transfection into mouse L cells of genes encoding two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygous animal : evidence for a second class I locus in cattle by TOYE, P. G, MACHUGH, N. D, BENSAID, A. M, ALBERTI, S, TEALE, A. J, MORRISON, W. I

“…w10 and KN104 are distinct class I major histocompatibility complex (MHC) serological specificities present in Boran (Bos indicus) cattle. Although these…”
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Bovine pan T-cell monoclonal antibodies reactive with a molecule similar to CD2 by DAVIS, W. C, ELLIS, J. A, MACHUGH, N. D, BALDWIN, C. L

“…Monoclonal antibodies (mAb) CH128A and CH61A react with molecules of 50,000-60,000 MW. They are expressed by all T cells in cattle, comprising 44-69% of…”
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Bovine afferent lymph veiled cells differ from blood monocytes in phenotype and accessory function by McKeever, DJ, MacHugh, ND, Goddeeris, BM, Awino, E, Morrison, WI

“…Veiled cells have been prepared from bovine afferent lymph and their surface phenotype has been compared with that of blood monocytes using a panel of mAb that…”
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Characterisation of a monoclonal antibody recognising the CD3 ε chain of the bovine T cell receptor complex by MacHugh, N.D, Mburu, J.K, Hamilton, M.J, Davis, W.C

“…We describe the characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine α β and γ δTcR…”
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Characterization of a bovine thymic differentiation antigen analogous to CD1 in the human by MacHugh, N D, Bensaid, A, Davis, W C, Howard, C J, Parsons, K R, Jones, B, Kaushal, A

“…Three monoclonal antibodies (MoAb), TH97A, CC13, and CC14, define a thymic differentiation antigen in cattle. The antigen is expressed on 50-60% of bovine…”
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Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45 by Howard, C J, Sopp, P, Parsons, K R, McKeever, D J, Taracha, E L, Jones, B V, MacHugh, N D, Morrison, W I

“…A murine IgG1 monoclonal antibody (mAb), CC76, has been produced that, based on findings of the relative molecular mass of polypeptides that it recognized,…”
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