Search Results - "MacGregor, R G"

Contribution of a bonded scholarship scheme to staffing rural health facilities by MacGregor, R G, Ross, A J

“…\r\nBackground\r\nLocal and international research has identified rural origin as an important reason why healthcare professionals (HCPs) work in rural areas,…”
Get full text

Alkaline Phosphatase Knock‐Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia by Fedde, Kenton N., Blair, Libby, Silverstein, Julie, Coburn, Stephen P., Ryan, Lawrence M., Weinstein, Robert S., Waymire, Katrina, Narisawa, Sonoko, Millán, José L., Macgregor, Grant R., Whyte, Michael P.

“…Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue‐nonspecific isoenzyme of alkaline phosphatase (TNSALP) and…”
Get full text

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator by Graham, Brett H, Waymire, Katrina G, Cottrell, Barbara, Trounce, Ian A, MacGregor, Grant R, Wallace, Douglas C

“…In an attempt to create an animal model of tissue-specific mitochondrial disease, we generated 'knockout' mice deficient in the heart/muscle isoform of the…”
Get full text

Throughput rates and time to completion of health science students of rural origin in South Africa by MacGregor, R G, Ross, A J

“…\r\nBackground\r\nThere is a shortage of qualified healthcare workers in South Africa (SA), as well as a maldistribution between urban and rural areas…”
Get full text

The training of healthcare professionals : an expense or an investment? by Ross, A.J., Zihindula, G., Chola, L., MacGregor, R.G.

“…Background. There is little information on the financial return of investment when funding the tertiary education of healthcare professionals (HCPs) in South…”
Get full text

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death by Wei, Michael C., Zong, Wei-Xing, Emily H. -Y. Cheng, Lindsten, Tullia, Panoutsakopoulou, Vily, Ross, Andrea J., Roth, Kevin A., MacGregor, Grant R., Thompson, Craig B., Korsmeyer, Stanley J.

“…Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID,…”
Get full text

An extreme bias in the germ line of XY C57BL/6<->XY FVB/N chimaeric mice by MacGregor, GR

“…Chimaeric analysis is a powerful method to address questions about the cell-autonomous nature of defects in spermatogenesis. Symplastic spermatids (sys) mice…”
Get full text

Spermatogenesis in Bclw-Deficient Mice by RUSSELL, Lonnie D, WARREN, Jeff, DEBELJUK, Luciano, RICHARDSON, Laura L, MAHAR, Patryce L, WAYMIRE, Katrina G, AMY, Scott P, ROSS, Andrea J, MACGREGOR, Grant R

“…Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice that are mutant for Bclw display progressive and nearly complete…”
Get full text

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore by Wallace, Douglas C, Kokoszka, Jason E, Waymire, Katrina G, Levy, Shawn E, Sligh, James E, Cai, Jiyang, Jones, Dean P, MacGregor, Grant R

“…A sudden increase in permeability of the inner mitochondrial membrane, the so-called mitochondrial permeability transition, is a common feature of apoptosis…”
Get full text

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak by Zong, W X, Lindsten, T, Ross, A J, MacGregor, G R, Thompson, C B

“…The BH3-only proteins Bim and Bad bind to the antiapoptotic Bcl-2 proteins and induce apoptosis in wild-type cells and cells from either bax(-/-) or bak(-/-)…”
Get full text

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues by Lindsten, Tullia, Ross, Andrea J, King, Ayala, Zong, Wei-Xing, Rathmell, Jeffrey C, Shiels, Helena A, Ulrich, Eugen, Waymire, Katrina G, Mahar, Patryce, Frauwirth, Kenneth, Chen, Yifeng, Wei, Michael, Eng, Vicki M, Adelman, David M, Simon, M.Celeste, Ma, Averil, Golden, Jeffrey A, Evan, Gerard, Korsmeyer, Stanley J, MacGregor, Grant R, Thompson, Craig B

“…Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic…”
Get full text

Scholarship success: Umthombo Youth Development Foundation by Ross, A J, MacGregor, R G

Get full text

Targeting of Hexokinase 1 to Liver and Hepatoma Mitochondria by Gelb, Bruce D., Adams, Volker, Jones, Stephen N., Griffin, Lisa D., MacGregor, Grant R., Edward R. B. Mc Cabe

“…The proportion of hexokinase (HK; EC 2.7.1.1) isozyme 1 (HK1) that is bound to the outer mitochondrial membrane is tissue specific and developmentally…”
Get full text

Expression of human adenosine deaminase in murine hematopoietic cells by BELMONT, J. W, MACGREGOR, G. R, WAGER-SMITH, K, FLETCHER, F. A, MOORE, K. A, HAWKINS, D, VILLALON, D, CHANG, S. M.-W, THOMAS CASKEY, C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Transfer of chloramphenicol-resistant mitochondrial DNA into the chimeric mouse by LEVY, S. E, WAYMIRE, K. G, KIM, Y. L, MACGREGOR, G. R, WALLACE, D. C

“…The mitochondrial DNA (mtDNA) chloramphenicol (CAP)-resistance (CAPR) mutation has been introduced into the tissues of adult mice via female embryonic stem…”
Get full text

It is time to balance communitarianism and individualism in South African medical education by Campbell, L M, Ross, A J, MacGregor, R G

“…To the Editor: Recent well-meaning global and South African (SA) reforms in medical education primarily consider an agenda of social accountability. We are…”
Get full text

Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6 by Waymire, K.G. (Emory University School of Medicine, Atlanta, GA.), Mahuren, J.D, Jaje, J.M, Guilarte, T.R, Coburn, S.P, MacGregor, G.R

“…In humans, deficiency of the tissue non-specific alkaline phosphatase (TNAP) gene is associated with defective skeletal mineralization. In contrast, mice…”
Get full text

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene by Esposito, Luke A., Kokoszka, Jason E., Waymire, Katrina G., Cottrell, Barbara, MacGregor, Grant R., Wallace, Douglas C.

“…Oxidative stress resulting from mitochondrially derived reactive oxygen species (ROS) has been hypothesized to damage mitochondrial oxidative phosphorylation…”
Get full text

Testicular degeneration in Bclw-deficient mice by Ross, A J, Waymire, K G, Moss, J E, Parlow, A F, Skinner, M K, Russell, L D, MacGregor, G R

“…To identify genes required for mammalian spermatogenesis, we screened lines of mutant mice created using a retroviral gene-trap system for male infertility…”
Get full text

The 5' Flanking Region of the Monogamous Prairie Vole Oxytocin Receptor Gene Directs Tissue-Specific Expression in Transgenic Mice by YOUNG, L. J., WAYMIRE, K. G., NILSEN, R., MACGREGOR, G. R., WANG, Z., INSEL, T. R.

Get full text