Search Results - "MacDonald, P J"

Sustained elevation of resistin, NGAL and IL-8 are associated with severe sepsis/septic shock in the emergency department by Macdonald, Stephen P J, Stone, Shelley F, Neil, Claire L, van Eeden, Pauline E, Fatovich, Daniel M, Arendts, Glenn, Brown, Simon G A

“…To identify biomarkers which distinguish severe sepsis/septic shock from uncomplicated sepsis in the Emergency Department (ED). Patients with sepsis underwent…”
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REstricted Fluid REsuscitation in Sepsis-associated Hypotension (REFRESH): study protocol for a pilot randomised controlled trial by Macdonald, Stephen P J, Taylor, David McD, Keijzers, Gerben, Arendts, Glenn, Fatovich, Daniel M, Kinnear, Frances B, Brown, Simon G A, Bellomo, Rinaldo, Burrows, Sally, Fraser, John F, Litton, Edward, Ascencio-Lane, Juan Carlos, Anstey, Matthew, McCutcheon, David, Smart, Lisa, Vlad, Ioana, Winearls, James, Wibrow, Bradley

“…Guidelines recommend an initial intravenous (IV) fluid bolus of 30 ml/kg isotonic crystalloid for patients with sepsis and hypotension. However, there is a…”
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Minimum spanning trees of weighted scale-free networks by Macdonald, P. J, Almaas, E, Barabási, A.-L

“…A complete characterization of real networks requires us to understand the consequences of the uneven interaction strengths between a system's components. Here…”
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Safety of peripheral administration of vasopressor medications: A systematic review by Tian, David H, Smyth, Claire, Keijzers, Gerben, Macdonald, Stephen PJ, Peake, Sandra, Udy, Andrew, Delaney, Anthony

“…Objective Vasopressor medications have traditionally been administered via central venous catheters (CVCs), primarily due to concerns of peripheral…”
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Restricted fluid resuscitation in suspected sepsis associated hypotension (REFRESH): a pilot randomised controlled trial by Macdonald, Stephen P. J., Keijzers, Gerben, Taylor, David McD, Kinnear, Frances, Arendts, Glenn, Fatovich, Daniel M., Bellomo, Rinaldo, McCutcheon, David, Fraser, John F., Ascencio-Lane, Juan-Carlos, Burrows, Sally, Litton, Edward, Harley, Amanda, Anstey, Matthew, Mukherjee, Ashes

“…Purpose To determine if a regimen of restricted fluids and early vasopressor compared to usual care is feasible for initial resuscitation of hypotension due to…”
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Neutrophil activation during acute human anaphylaxis: analysis of MPO and sCD62L by Francis, A., Bosio, E., Stone, S. F., Fatovich, D. M., Arendts, G., Nagree, Y., Macdonald, S. P. J., Mitenko, H., Rajee, M., Burrows, S., Brown, S. G. A.

“…Summary Background The mechanisms involved in the amplification of the mast cell response during anaphylaxis are unclear. Mouse models of anaphylaxis…”
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Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan by Smart, Lisa, Bosio, Erika, Macdonald, Stephen P.J., Dull, Randal, Fatovich, Daniel M., Neil, Claire, Arendts, Glenn

“…Endocan, a component of the endothelial glycocalyx (EG), has been linked with respiratory failure in sepsis. This study explored the temporal patterns of three…”
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Prospective validation study of prognostic biomarkers to predict adverse outcomes in patients with COVID-19: a study protocol by Tang, Benjamin, Shojaei, Maryam, Wang, Ya, Nalos, Marek, Mclean, Anthony, Afrasiabi, Ali, Kwan, Tim N, Kuan, Win Sen, Zerbib, Yoann, Herwanto, Velma, Gunawan, Gunawan, Bedognetti, Davide, Zoppoli, Gabriele, Ballestrero, Alberto, Rinchai, Darawan, Cremonesi, Paolo, Bedognetti, Michele, Matejovic, Martin, Karvunidis, Thomas, Macdonald, Stephen P J, Cox, Amanda J, West, Nicholas P, Cripps, Allan William, Schughart, Klaus, Maria, Andrea de, Chaussabel, Damien, Iredell, Jonathan, Weng, Stephen

“…IntroductionAccurate triage is an important first step to effectively manage the clinical treatment of severe cases in a pandemic outbreak. In the current…”
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Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis by Macdonald, Stephen P. J., Bosio, Erika, Neil, Claire, Arendts, Glenn, Burrows, Sally, Smart, Lisa, Brown, Simon G. A., Fatovich, Daniel M.

“…Objective and design Resistin and neutrophil gelatinase-associated lipocalin (NGAL) are upregulated in circulating leucocytes in sepsis, but the significance…”
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Spontaneous pneumothorax; a multicentre retrospective analysis of emergency treatment, complications and outcomes by Brown, S. G. A., Ball, E. L., Macdonald, S. P. J., Wright, C., McD Taylor, D.

“…Background Spontaneous pneumothorax can be managed initially by observation, aspiration or chest drain insertion. Aims To determine the clinical features of…”
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Comparison of PIRO, SOFA, and MEDS Scores for Predicting Mortality in Emergency Department Patients With Severe Sepsis and Septic Shock by Macdonald, Stephen P. J., Arendts, Glenn, Fatovich, Daniel M., Brown, Simon G. A., Merchant, Roland C.

“…Objectives The Predisposition Insult Response and Organ failure (PIRO) scoring system has been developed for use in the emergency department (ED) to risk…”
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Endothelial glycocalyx biomarkers increase in patients with infection during Emergency Department treatment by Smart, Lisa, Macdonald, Stephen P.J., Burrows, Sally, Bosio, Erika, Arendts, Glenn, Fatovich, Daniel M.

“…Endothelial glycocalyx (EG) shedding may promote organ failure in sepsis. This study describes temporal changes in EG biomarkers from Emergency Department (ED)…”
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Bolus therapy with 3% hypertonic saline or 0.9% saline in emergency department patients with suspected sepsis: A pilot randomised controlled trial by Smart, Lisa, Macdonald, Stephen P.J., Bosio, Erika, Fatovich, Daniel, Neil, Claire, Arendts, Glenn

“…Hypertonic saline administered during fluid resuscitation may mitigate endothelial glycocalyx (EG) shedding and inflammation. The objective of this pilot…”
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Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans by McGrath, Francesca M, Francis, Abbie, Fatovich, Daniel M, Macdonald, Stephen PJ, Arendts, Glenn, Woo, Andrew J, Bosio, Erika

“…Objective Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by…”
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Do risks outweigh benefits in thrombolysis for stroke? by Brown, Simon G A, Macdonald, Stephen P J, Hankey, Graeme J

“…Simon Brown and Stephen Macdonald argue that patients with stroke should not be given thrombolysis outside clinical trials, but Graeme Hankey says the benefits…”
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Is comorbid status the best predictor of one-year mortality in patients with severe sepsis and sepsis with shock? by Huddle, N, Arendts, G, Macdonald, S P J, Fatovich, D M, Brown, S G A

“…Understanding longer term outcomes in critically ill patients will assist treatment decisions, allocation of scarce resources and clinical research in that…”
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Re: Vaginal examination does not improve diagnostic accuracy in early pregnancy bleeding by Macdonald, Stephen PJ, Fowler, Liza

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Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial by Self, Wesley H., Semler, Matthew W., Bellomo, Rinaldo, Brown, Samuel M., deBoisblanc, Bennett P., Exline, Matthew C., Ginde, Adit A., Grissom, Colin K., Janz, David R., Jones, Alan E., Liu, Kathleen D., Macdonald, Stephen P.J., Miller, Chadwick D., Park, Pauline K., Reineck, Lora A., Rice, Todd W., Steingrub, Jay S., Talmor, Daniel, Yealy, Donald M., Douglas, Ivor S., Shapiro, Nathan I.

“…Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid…”
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Improving stress testing compliance following chest pain presentations to the emergency department by Chung, Kevin, Playford, David, Macdonald, Stephen PJ

“…Objectives To determine whether a booked appointment time improves early outpatient exercise stress testing (EST) guideline adherence in patients discharged…”
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Comparison of two clinical scoring systems for emergency department risk stratification of suspected acute coronary syndrome by Macdonald, Stephen PJ, Nagree, Yusuf, Fatovich, Daniel M, Flavell, Helen L, Loutsky, Francis

“…Objective: To compare two methods of risk stratification for suspected acute coronary syndrome (ACS) in the ED. Methods: A prospective observational…”
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