Search Results - "MacDonald, Melissa J."

Catalysis through Temporary Intramolecularity: Mechanistic Investigations on Aldehyde-Catalyzed Cope-type Hydroamination Lead to the Discovery of a More Efficient Tethering Catalyst by Guimond, Nicolas, MacDonald, Melissa J, Lemieux, Valérie, Beauchemin, André M

“…Mechanistic investigations on the aldehyde-catalyzed intermolecular hydroamination of allylic amines using N-alkylhydroxylamines are presented. Under the…”
Get full text

A Catalytic Tethering Strategy: Simple Aldehydes Catalyze Intermolecular Alkene Hydroaminations by MacDonald, Melissa J, Schipper, Derek J, Ng, Peter J, Moran, Joseph, Beauchemin, André M

“…Herein we describe a catalytic tethering strategy in which simple aldehyde precatalysts enable, through temporary intramolecularity, room-temperature…”
Get full text

Formaldehyde as Tethering Organocatalyst: Highly Diastereoselective Hydroaminations of Allylic Amines by Hesp, Colin R, MacDonald, Melissa J, Zahedi, M. Mehdi, Bilodeau, Didier A, Zhao, Shu-Bin, Pesant, Marc, Beauchemin, André M

“…Catalysts possessing sufficient activity to achieve intermolecular alkene hydroaminations under mild conditions are rare, and this likely accounts for the…”
Get full text

Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis by MacDonald, Melissa J, Lavis, Luke D, Hilvert, Donald, Gellman, Samuel H

“…Efficient hydrolysis of amide bonds has long been a reaction of interest for organic chemists. The rate constants of proteases are unmatched by those of any…”
Get full text

Inhibition of Ice Recrystallization by Nylon‑3 Polymers by MacDonald, Melissa J, Cornejo, Natasha R, Gellman, Samuel H

“…Nontoxic cryoprotectants are needed for storage of tissues and food preservation. Frozen tissue is particularly susceptible to damage caused by formation of…”
Get full text

Highly Enantioselective Intermolecular Hydroamination of Allylic Amines with Chiral Aldehydes as Tethering Catalysts by MacDonald, Melissa J., Hesp, Colin R., Schipper, Derek J., Pesant, Marc, Beauchemin, André M.

“…Chirally LinkedIn: Chiral aldehydes are effective tethering catalysts for enantioselective intermolecular hydroamination, which provides access to vicinal…”
Get full text

On the Ability of Formaldehyde to Act as a Tethering Catalyst in Water by Jamshidi, Mohammad P., MacDonald, Melissa J., Beauchemin, André M.

“…The low concentration issue is a fundamental challenge when it comes to prebiotic chemistry, as macromolecular systems need to be assembled via intermolecular…”
Get full text