Search Results - "MacDonald, M. E"

Rethinking Oral Health in Aging: Ecosocial Theory and Intersectionality by Slack-Smith, L., Ng, T., Macdonald, M.E., Durey, A.

“…Poor oral health affects the health and well-being of older adults in many ways. Despite years of international research investigating poor oral health among…”
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Obstetric conditions and the placental weight ratio by Macdonald, E.M, Natale, R, Regnault, T.R.H, Koval, J.J, Campbell, M.K

“…Abstract Introduction To elucidate how obstetric conditions are associated with atypical placental weight ratios (PWR)s in infants born: (a) ≥37 weeks…”
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Factors associated with HD CAG repeat instability in Huntington disease by Wheeler, V C, Persichetti, F, McNeil, S M, Mysore, J S, Mysore, S S, MacDonald, M E, Myers, R H, Gusella, J F, Wexler, N S

“…Background:The Huntington disease (HD) CAG repeat exhibits dramatic instability when transmitted to subsequent generations. The instability of the HD disease…”
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Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease by Zuccato, Chiara, Ciammola, Andrea, Rigamonti, Dorotea, Leavitt, Blair R., Goffredo, Donato, Conti, Luciano, MacDonald, Marcy E., Friedlander, Robert M., Silani, Vincenzo, Hayden, Michael R., Timmusk, Tõnis, Sipione, Simonetta, Cattaneo, Elena

“…Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's disease (HD), a neurodegenerative disorder. The mutant protein is…”
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Oral health-related stigma: Describing and defining a ubiquitous phenomenon by Doughty, J, Macdonald, M E, Muirhead, V, Freeman, R

“…This paper is the fourth of a series of narrative reviews to critically rethink underexplored concepts in oral health research. The series commenced with an…”
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The quantity and quality of the social networks of young people with early psychosis compared with closely matched controls by Macdonald, E.M, Hayes, R.L, Baglioni, A.J

“…This study compares the social networks and perceived social support of 26 people with early psychosis and 26 people without a mental illness. The two groups…”
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Huntingtin Interacts with a Family of WW Domain Proteins by Faber, Peter W., Barnes, Glenn T., Srinidhi, Jayalakshmi, Chen, Jianmin, Gusella, James F., MacDonald, Marcy E.

“…The hallmark neuropathology of Huntington's disease (HD) is due to elongation of a polyglutamine segment in huntingtin, a novel ∼350 kDa protein of unknown…”
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Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1 by Kim, HG, Herrick, S R, Lemyre, E, Kishikawa, S, Salisz, J A, Seminara, S, MacDonald, M E, Bruns, G A P, Morton, C C, Quade, B J, Gusella, J F

“…Hybridisation of labelled fragments was done in the presence of excess herring sperm competitor DNA, and hybridised membranes were washed at 60°C with 0.15 M…”
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CAG repeat number governs the development rate of pathology in Huntington's disease by Penney, Jr, J B, Vonsattel, J P, MacDonald, M E, Gusella, J F, Myers, R H

“…We compared the number of CAG repeats, the age at death, and the severity of neuropathology in 89 Huntington's disease brains. We found a linear correlation…”
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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion by White, Jacqueline K, Auerbach, Wojtek, Duyao, Mabel P, Vonsattel, Jean-Paul, Gusella, James F, Joyner, Alexandra L, MacDonald, Marcy E

“…Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion that lengthens a glutamine segment in the novel…”
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Evidence for the GluR6 gene associated with younger onset age of Huntington's disease by MACDONALD, M. E, VONSATTEL, J. P, SHRINIDHI, J, COUROPMITREE, N. N, CUPPLES, L. A, BIRD, E. D, GUSELLA, J. F, MYERS, R. H

“…Huntington's disease (HD) is attributed to a triplet CAG repeat mutation, and about half of the variation in onset age can be explained by the size of the…”
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Length-Dependent Gametic CAG Repeat Instability in the Huntington's Disease Knock-in Mouse by Wheeler, Vanessa C., Auerbach, Wojtek, White, Jacqueline K., Srinidhi, Jayalakshmi, Auerbach, Anna, Ryan, Angela, Duyao, Mabel P., Vrbanac, Vladimir, Weaver, Meredith, Gusella, James F., Joyner, Alexandra L., MacDonald, Marcy E.

“…The CAG repeats in the human Huntington's disease (HD) gene exhibit striking length-dependent intergenerational instability, typically small size increases or…”
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Herbicide exposure modifies GSTP1 haplotype association to parkinson onset age : The GenePD study by WILK, J. B, TOBIN, J. E, SINGER, C, GROWDON, J. H, LATOURELLE, J. C, SAINT-HILAIRE, M. H, DESTEFANO, A. L, PRAKASH, R, WILLIAMSON, S, BERG, C. J, SUN, M, GOLDWURM, S, SUCHOWERSKY, O, PEZZOLI, G, RACETTE, B. A, PERLMUTTER, J. S, PARSIAN, A, BAKER, K. B, GIROUX, M. L, LITVAN, I, PRAMSTALLER, P. P, NICHOLSON, G, BURN, D. J, SHILL, H. A, CHINNERY, P. F, VIEREGGE, P, SLEVIN, J. T, CAMBI, F, MACDONALD, M. E, GUSELLA, J. F, MYERS, R. H, GOLBE, L. I, KLEIN, C, WOOTEN, G. F, LEW, M. F, MARK, M. H, GUTTMAN, M, WATTS, R. L

“…Polymorphisms in the glutathione S-transferase pi gene (GSTP1), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with…”
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Clinical and genetic heterogeneity in benign hereditary chorea by BREEDVELD, G. J, PERCY, A. K, MACDONALD, M. E, DE VRIES, B. B. A, YAPIJAKIS, C, DURE, L. S, IPPEL, E. F, SANDKUIJL, L. A, HEUTINK, P, ARTS, W. F. M

“…Benign hereditary chorea (BHC) is an autosomal dominant disorder that can be distinguished from Huntington disease by its early onset, stable or only slightly…”
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Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease by Djoussé, L., Knowlton, B., Hayden, M., Almqvist, E.W., Brinkman, R., Ross, C., Margolis, R., Rosenblatt, A., Durr, A., Dode, C., Morrison, P.J., Novelletto, A., Frontali, M., Trent, R.J.A., McCusker, E., Gómez-Tortosa, E., Mayo, D., Jones, R., Zanko, A., Nance, M., Abramson, R., Suchowersky, O., Paulsen, J., Harrison, M., Yang, Q., Cupples, L.A., Gusella, J.F., MacDonald, M.E., Myers, R.H.

“…Huntington disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the HD gene on chromosome 4p16.3. Past studies have…”
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Reduced Penetrance of the Huntington's Disease Mutation by McNeil, Sandra M., Novelletto, Andrea, Srinidhi, Jayalakshmi, Barnes, Glenn, Kornbluth, Ira, Altherr, Michael R., Wasmuth, John J., Gusella, James F., MacDonald, Marcy E., Myers, Richard H.

“…Controversy persists concerning the significance of Huntington disease (HD) alleles in the 36–39 repeat range. Although some clinically affected persons have…”
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De novo expansion of a (CAG) n repeat in sporadic Huntington's disease by Myers, R. H, MacDonald, M. E, Koroshetz, W. J, Duyao, M. P, Ambrose, C. M, Taylor, S. A. M, Barnes, G, Srinidhi, J, Lin, C. S, Whaley, W. L, Lazzarini, A. M, Schwarz, M, Wolff, G, Bird, E. D, Vonsattel, J.-P. G, Gusella, J. F

“…Huntington's disease (HD) chromosomes contain an expanded unstable (CAG)n repeat in chromosome 4p16.3. We have examined nine families with potential de novo…”
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Neocortical neurons cultured from mice with expanded cag repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults by Snider, B.J, Moss, J.L, Revilla, F.J, Lee, C.-S, Wheeler, V.C, Macdonald, M.E, Choi, D.W

“…Glutamate-mediated excitotoxicity might contribute to the pathogenesis of Huntington's disease and other polyglutamine repeat disorders. We used murine…”
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Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis by PASSANI, L. A, BEDFORD, M. T, FABER, P. W, MCGINNIS, K. M, SHARP, A. H, GUSELLA, J. F, VONSATTEL, J.-P, MACDONALD, M. E

“…An elongated glutamine tract in mutant huntingtin initiates Huntington's disease (HD) pathogenesis via a novel structural property that displays neuronal…”
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Genome-wide scan for Parkinson's disease: The genePD Study by DESTEFANO, A. L, GOLBE, L. I, LAFONTAINE, A. L, LABELLE, N, LEW, M. F, WATERS, C. H, GROWDON, J. H, SINGER, C, CURRIE, L. J, WOOTEN, G. F, VIEREGGE, P, PRAMSTALLER, P. P, MARK, M. H, KLEIN, C, HUBBLE, J. P, STACY, M, MONTGOMERY, E, MACDONALD, M. E, GUSELLA, J. F, MYERS, R. H, LAZZARINI, A. M, MAHER, N. E, SAINT-HILAIRE, M, FELDMAN, R. G, GUTTMAN, M, WATTS, R. L, SUCHOWERSKY, O

“…A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214…”
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