Search Results - "MacDonald, Karen V"

An individualized patient-reported outcome measure (PROM) based patient decision aid and surgeon report for patients considering total knee arthroplasty: protocol for a pragmatic randomized controlled trial by Bansback, Nick, Trenaman, Logan, MacDonald, Karen V, Hawker, Gillian, Johnson, Jeffrey A, Stacey, Dawn, Marshall, Deborah A

“…While the rates of total knee arthroplasty (TKA) continue to rise worldwide, there are concerns about whether all surgeries are appropriate. Guidelines for…”
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Estimating Preferences for Complex Health Technologies: Lessons Learned and Implications for Personalized Medicine by Marshall, Deborah A., PhD, Gonzalez, Juan Marcos, PhD, MacDonald, Karen V., MPH, Johnson, F. Reed, PhD

“…Abstract We examine key study design challenges of using stated-preference methods to estimate the value of whole-genome sequencing (WGS) as a specific example…”
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Patient preferences for active ulcerative colitis treatments and fecal microbiota transplantation by Marshall, Deborah A, MacDonald, Karen V, Kao, Dina, Bernstein, Charles N, Kaplan, Gilaad G, Jijon, Humberto, Hazlewood, Glen, Panaccione, Remo, Nasser, Yasmin, Raman, Maitreyi, Moayyedi, Paul

“…Fecal microbiota transplantation (FMT) is a promising treatment for active ulcerative colitis (UC). Understanding patient preferences can identify treatment…”
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An online individualised patient decision aid improves the quality of decisions in patients considering total knee arthroplasty in routine care: A randomized controlled trial by Bansback, Nick, Trenaman, Logan, MacDonald, Karen V., Durand, D'Arcy, Hawker, Gillian, Johnson, Jeffrey A., Smith, Christopher, Stacey, Dawn, Marshall, Deborah A.

“…The objective of this study was to evaluate the effectiveness of an online patient decision aid with individualised potential outcomes of surgery, on the…”
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S871 Patient Satisfaction With and Access to Virtual Healthcare for Inflammatory Bowel Disease During the COVID-19 Pandemic by Sewitch, Maida J., MacDonald, Karen V., Marshall, Deborah A., Nguyen, Geoffrey

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Preliminary results from a multicenter, randomized trial using fecal microbial transplantation to induce remission in patients with mild to moderate Crohn’s disease by Kao, Dina, Wong, Karen, Jijon, Humberto, Moayyedi, Paul, Franz, Rose, McDougall, Chelsea, Hotte, Naomi, Panaccione, Remo, Semlacher, Eric, Kroeker, Karen I., Peerani, Farhad, MacDonald, Karen V., Xu, Huiping, Narula, Neeraj, Turbide, Christian, Marshall, Deborah A, Madsen, Karen L

“…Introduction: Fecal microbial transplantation (FMT) has shown promise at inducing remission in ulcerative colitis. This study is the first of its kind to…”
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(Un)standardized testing: the diagnostic odyssey of children with rare genetic disorders in Alberta, Canada by Michaels-Igbokwe, Christine, McInnes, Brenda, MacDonald, Karen V., Currie, Gillian R., Omar, Fadya, Shewchuk, Brittany, Bernier, Francois P., Marshall, Deborah A.

“…Purpose We provide a description of the diagnostic odyssey for a cohort of children seeking diagnosis of a rare genetic disorder in terms of the time from…”
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Are We Capturing the Socioeconomic Burden of Rare Genetic Disease? A Scoping Review of Economic Evaluations and Cost-of-Illness Studies by Marshall, Deborah A., Gerber, Brittany, Lorenzetti, Diane L., MacDonald, Karen V., Bohach, Riley Jewel, Currie, Gillian R.

“…Background and Objectives Rare diseases have a significant impact on patients, families, the health system, and society. Measuring the socioeconomic burden is…”
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The value of diagnostic testing for parents of children with rare genetic diseases by Marshall, Deborah A., MacDonald, Karen V., Heidenreich, Sebastian, Hartley, Taila, Bernier, Francois P., Gillespie, Meredith K., McInnes, Brenda, Innes, A. Micheil, Armour, Christine M., Boycott, Kym M.

“…Purpose Exome sequencing (ES) can rapidly identify disease-causing variants responsible for rare, single-gene diseases, and potentially reduce the duration of…”
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Impact of an online, individualised, patient reported outcome measures based patient decision aid on patient expectations, decisional regret, satisfaction, and health‐related quality‐of‐life for patients considering total knee arthroplasty: Results from a randomised controlled trial by Marshall, Deborah A., Trenaman, Logan, MacDonald, Karen V., Johnson, Jeffrey A., Stacey, Dawn, Hawker, Gillian, Smith, Christopher, Durand, D'Arcy, Bansback, Nick

“…Rationale Total knee arthroplasty is a common surgical procedure but not appropriate for all patients with knee osteoarthritis. Patient decision aids (PtDAs)…”
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How do women trade-off benefits and risks in chemotherapy treatment decisions based on gene expression profiling for early-stage breast cancer? A discrete choice experiment by Marshall, Deborah A, Deal, Ken, Bombard, Yvonne, Leighl, Natasha, MacDonald, Karen V, Trudeau, Maureen

“…ObjectivesGene expression profiling (GEP) of tumours informs baseline risk prediction, potentially affecting adjuvant chemotherapy decisions for women with…”
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Exploring How Values of Colorectal Cancer Patients and their Caregivers Influence Treatment Decision-Making by Mirza, Raza M, Salim, Sabrin, Bell, Jennifer A H, Esplen, Mary Jane, MacDonald, Karen V, Stein, Barry D, Marshall, Deborah A

“…As we adopt value models to inform drug reimbursement, coverage, clinical trials, and treatment choices, aligning these models to reflect patient values and…”
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The influence of gene expression profiling on decisional conflict in decision making for early-stage breast cancer chemotherapy by MacDonald, Karen V, Bombard, Yvonne, Deal, Ken, Trudeau, Maureen, Leighl, Natasha, Marshall, Deborah A

“…Abstract Background Women with early-stage breast cancer, of whom only 15% will experience a recurrence, are often conflicted or uncertain about taking…”
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Direct health-care costs for children diagnosed with genetic diseases are significantly higher than for children with other chronic diseases by Marshall, Deborah A., Benchimol, Eric I., MacKenzie, Alex, Duque, Daniel Rodriguez, MacDonald, Karen V., Hartley, Taila, Howley, Heather, Hamilton, Alison, Gillespie, Meredith, Malam, Faheem, Boycott, Kym M.

“…Purpose We aimed to estimate direct health-care costs and physician utilization for a cohort of children diagnosed with genetic diseases. Methods Retrospective…”
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Estimating the Burden of Osteoarthritis to Plan for the Future by Marshall, Deborah A., Vanderby, Sonia, Barnabe, Cheryl, MacDonald, Karen V., Maxwell, Colleen, Mosher, Dianne, Wasylak, Tracy, Lix, Lisa, Enns, Ed, Frank, Cy, Noseworthy, Tom

“…Objective With aging and obesity trends, the incidence and prevalence of osteoarthritis (OA) is expected to rise in Canada, increasing the demand for health…”
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What are people willing to pay for whole-genome sequencing information, and who decides what they receive? by Marshall, Deborah A., Gonzalez, Juan Marcos, Johnson, F. Reed, MacDonald, Karen V., Pugh, Amy, Douglas, Michael P., Phillips, Kathryn A.

“…Whole-genome sequencing (WGS) can be used as a powerful diagnostic tool as well as for screening, but it may lead to anxiety, unnecessary testing, and…”
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Symptom onset, diagnosis and management of osteoarthritis by MacDonald, Karen V, Sanmartin, Claudia, Langlois, Kellie, Marshall, Deborah A

“…The time between symptom onset and physician diagnosis is a period when people with osteoarthritis can make lifestyle changes to reduce pain, improve function…”
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Methods for Conducting Stated Preference Research with Children and Adolescents in Health: A Scoping Review of the Application of Discrete Choice Experiments by Michaels-Igbokwe, Christine, Currie, Gillian R., Kennedy, Bryanne L., MacDonald, Karen V., Marshall, Deborah A.

“…Background Discrete choice experiments (DCEs) are a common method used to describe and quantitatively assess preferences in health applications. Increasingly,…”
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Correction: The value of diagnostic testing for parents of children with rare genetic diseases by Marshall, Deborah A., MacDonald, Karen V., Heidenreich, Sebastian, Hartley, Taila, Bernier, Francois P., Gillespie, Meredith K., McInnes, Brenda, Innes, A. Micheil, Armour, Christine M., Boycott, Kym M.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Correction: Corrigendum: What are people willing to pay for whole-genome sequencing information, and who decides what they receive? by Marshall, Deborah A., Gonzalez, Juan Marcos, Johnson, F. Reed, MacDonald, Karen V., Pugh, Amy, Douglas, Michael P., Phillips, Kathryn A.

“…Correction to: Genetics in Medicine (2016) 18, 1295–1302 doi:10.1038/gim.2016.61 In the published version of this article, the ranges of willingness to pay on…”
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