Search Results - "MacDonald, James I. S."

Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells by Li, Chunhui, MacDonald, James I.S, Hryciw, Todd, Meakin, Susan O

“…J. Neurochem. (2009) 112, 882-899. Ectopic expression of the TrkA receptor tyrosine kinase in tumors of the nervous system can mediate nerve growth factor…”
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Ras Guanine Nucleotide Releasing Factor 1 (RasGrf1) Enhancement of Trk Receptor-Mediated Neurite Outgrowth Requires Activation of Both H-Ras and Rac by Talebian, Asghar, Robinson-Brookes, Kim, MacDonald, James I. S., Meakin, Susan O.

“…We previously demonstrated that the guanine nucleotide exchange factor, RasGrf1, binds nerve growth factor (NGF)-activated TrkA and facilitates…”
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fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons by Hryciw, Todd, MacDonald, James I.S, Phillips, Renée, Seah, Claudia, Pasternak, Stephen, Meakin, Susan O

“…J. Neurochem. (2009) 112, 924-939. Fibroblast growth factor (FGF) mediated signaling is essential to many aspects of neural development. Activated FGF…”
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Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons by MacDonald, James I. S., Dietrich, Alfonso, Gamble, Sarah, Hryciw, Todd, Grant, Robert Ian, Meakin, Susan O.

“…J. Neurochem. (2012) 121, 861–880. Vesicular transport in neurons plays a vital role in neuronal function and survival. Nesca is a novel protein that we…”
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Neutralizing intraspinal nerve growth factor with a trkA-IgG fusion protein blocks the development of autonomic dysreflexia in a clip-compression model of spinal cord injury by Marsh, Daniel R, Wong, Sharon T, Meakin, Susan O, MacDonald, James I S, Hamilton, Eilis F, Weaver, Lynne C

“…Increased intraspinal nerve growth factor (NGF) after spinal cord injury (SCI) is detrimental to the autonomic nervous system. Autonomic dysreflexia is a…”
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Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells by Li, Chunhui, MacDonald, James I. S., Talebian, Asghar, Leuenberger, Jennifer, Seah, Claudia, Pasternak, Stephen H., Michnick, Stephen W., Meakin, Susan O.

“…Macropinocytosis is a normal cellular process by which cells internalize extracellular fluids and nutrients from their environment and is one strategy that…”
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Human Tumorous Imaginal Disc 1 (TID1) Associates with Trk Receptor Tyrosine Kinases and Regulates Neurite Outgrowth in nnr5-TrkA Cells by Liu, Hui-Yu, MacDonald, James I.S., Hryciw, Todd, Li, Chunhui, Meakin, Susan O.

“…The human tumorous imaginal disc 1 (TID1) proteins including TID1L and TID1S, members of the DnaJ domain protein family, are involved in multiple intracellular…”
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Neurotrophin-dependent Tyrosine Phosphorylation of Ras Guanine-releasing Factor 1 and Associated Neurite Outgrowth Is Dependent on the HIKE Domain of TrkA by Robinson, Kim N., Manto, Kara, Buchsbaum, Rachel J., MacDonald, James I.S., Meakin, Susan O.

“…Ras guanine-releasing factor 1 (RasGrf1), a guanine nucleotide exchange factor for members of the Ras and Rho family of GTPases, is highly expressed in the…”
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Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3 by Dixon, Scott J., MacDonald, James I.S., Robinson, Kim N., Kubu, Christopher J., Meakin, Susan O.

“…We have investigated the signaling properties of the fibroblast growth factor (FGF) receptor substrate 3 (FRS3), also known as SNT-2 or FRS2β, in…”
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Nesca, a Novel Adapter, Translocates to the Nuclear Envelope and Regulates Neurotrophin-Induced Neurite Outgrowth by James I. S. Mac Donald, Kubu, Chris J., Meakin, Susan O.

“…We provide the first characterization of a novel signaling adapter, Nesca, in neurotrophic signal transduction. Nesca contains a RUN domain, a WW domain, a…”
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Direct Binding of the Signaling Adapter Protein Grb2 to the Activation Loop Tyrosines on the Nerve Growth Factor Receptor Tyrosine Kinase, TrkA by MacDonald, James I.S., Gryz, Ela A., Kubu, Chris J., Verdi, Joseph M., Meakin, Susan O.

“…We demonstrate that the signaling adapter, Grb2, binds directly to the neurotrophin receptor tyrosine kinase, TrkA. Grb2 binding to TrkA is independent of Shc,…”
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Identification of the Nuclear Localization Signal of Rat Liver CTP:Phosphocholine Cytidylyltransferase (∗) by Wang, Yuli, MacDonald, James I.S., Kent, Claudia

“…phosphocholine cytidylyltransferase (CT) is a major regulatory enzyme in phosphatidylcholine synthesis in mammalian cells. CT is found in both soluble and…”
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Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3 by MacDonald, J I, Verdi, J M, Meakin, S O

“…Many responses to nerve growth factor (NGF) are regulated through the receptor tyrosine kinase trkA. To understand more fully the functions of trkA in NGF…”
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Activity-dependent interaction of the intracellular domain of rat TrkA with intermediate filament proteins, the [beta]-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3 by Macdonald, James I; S, Verdi, Joseph M, Meakin, Susan O

“…Many responses to nerve growth factor (NGF) are regulated through the receptor tyrosine kinase trkA. To understand more fully the functions of trkA in NGF…”
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A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor‐Dependent Cell Survival but Not Neurite Outgrowth by Meakin, Susan O., Gryz, Ela A., MacDonald, James I. S.

“…: To investigate potential differences between the family of Trk receptors that might have differential consequences on cell signaling, we generated a rat TrkA…”
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The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA by Meakin, Susan O., MacDonald, James I.S., Gryz, Ela A., Kubu, Christopher J., Verdi, Joseph M.

“…We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated…”
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