Search Results - "MacDonald, Bruce C."

Package selection for moisture protection for solid, oral drug products by Waterman, Kenneth C, MacDonald, Bruce C

“…This review describes how best to select the appropriate packaging options for solid, oral drug products based on both chemical and physical stability, with…”
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Reversible Sensorineural Hearing Loss Resulting from Hypertrophic Pachymeningitis in Systemic Lupus Erythematosus: A Case Report by Bullington, Molly, Davies, George, MacDonald, C. Bruce

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Improved protocol and data analysis for accelerated shelf-life estimation of solid dosage forms by WATERMAN, Kenneth C, CARELLA, Anthony J, GUMKOWSKI, Michael J, LUKULAY, Patrick, MACDONALD, Bruce C, ROY, Michael C, SHAMBLIN, Sheri L

“…To propose and test a new accelerated aging protocol for solid-state, small molecule pharmaceuticals which provides faster predictions for drug substance and…”
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Peri-implant bony overgrowth as a cause of revision surgery in auditory osseointegrated implantation by Tompkins, Jared J., M.D, Petersen, Dana K., M.D., D.D.S, Sharbel, Daniel D., B.S, McKinnon, Brian J., M.D., M.P.H, MacDonald, C. Bruce, M.D

“…Abstract Implantation of auditory osseointegrated implants, also known as bone-anchored hearing systems (BAHS), represent a surgical option for select…”
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Modeling of in-use stability for tablets and powders in bottles by Waterman, Kenneth C., Chen, Lili, Waterman, Philip, MacDonald, Bruce C., Monahan, Andrew P., Scrivens, Garry

“…A model is presented for determining the time when an active pharmaceutical ingredient in tablets/powders will remain within its specification limits during an…”
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Enhancing the Dissolution Stability of Hard Gelatin Capsules Using Activated Carbon as a Packaging Component by Likar, Michael D, Carroll, Sophia C, Colgan, Stephen T, Yeoh, Thean, MacDonald, Bruce C, Johnson, Gail M, Space, J Sean

“…Hard gelatin capsule (HGC) shells are widely used to encapsulate drugs for oral delivery but are vulnerable to gelatin cross-linking, which can lead to slower…”
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Osmotic capsules: A universal oral, controlled-release drug delivery dosage form by Waterman, Kenneth C., Goeken, G. Scott, Konagurthu, Sanjay, Likar, Michael D., MacDonald, Bruce C., Mahajan, Nidhi, Swaminathan, Vidya

“…An osmotic, oral, controlled-release capsule is described. This capsule provides drug delivery at fixed delivery rates (T 80% = 6 or 14 h) independent of drug…”
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Relative humidity hysteresis in solid-state chemical reactivity: a pharmaceutical case study by Waterman, Kenneth C, Gerst, Paul, Macdonald, Bruce C

“…The chemical reaction rate for solid-state product formation in a pharmaceutical case study was monitored by equilibration with either a 75%, 21.5%, 75%…”
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Extrudable core system: Development of a single-layer osmotic controlled-release tablet by Waterman, Kenneth C., MacDonald, Bruce C., Roy, Michael C.

“…A new controlled-release, extrudable core system (ECS) tablet has been developed which osmotically delivers high doses of low solubility active pharmaceutical…”
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Use of Activated Carbon in Packaging to Attenuate Formaldehyde-Induced and Formic Acid-Induced Degradation and Reduce Gelatin Cross-Linking in Solid Dosage Forms by Colgan, Stephen T, Zelesky, Todd C, Chen, Raymond, Likar, Michael D, MacDonald, Bruce C, Hawkins, Joel M, Carroll, Sophia C, Johnson, Gail M, Space, J Sean, Jensen, James F, DeMatteo, Vincent A

“…Formaldehyde and formic acid are reactive impurities found in commonly used excipients and can be responsible for limiting drug product shelf-life. Described…”
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N-methylation and N-formylation of a secondary amine drug (varenicline) in an osmotic tablet by Waterman, Kenneth C, Arikpo, William B, Fergione, Michael B, Graul, Timothy W, Johnson, Barbara A, Macdonald, Bruce C, Roy, Michael C, Timpano, Robert J

“…Significant degradation of the amine-based smoking cessation drug varenicline tartrate in an early development phase osmotic, controlled-release (CR)…”
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Otologic photography: Indications and technique by MacDonald, C. Bruce

“…Educational objectives: To understand the benefits of photodocumentation of otologic disease with respect to patient counseling, informed consent, billing,…”
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Systemic absorption of gentamicin nasal irrigations by Whatley, W Stites, Chandra, Rakesh K, MacDonald, C Bruce

“…To determine if gentamicin nasal irrigation is systemically absorbed, and to identify any ototoxic side effects related to its use. Retrospective review of 12…”
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Correction of fluorescence inner filter effects and the partitioning of pyrene to dissolved organic carbon by MacDonald, Bruce C., Lvin, Sergey J., Patterson, Howard

“…The ability of dissolved organic carbon (DOC) to bind pyrene can be monitored by fluorescence quenching. Inner filter effects, caused by DOC, complicate the…”
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Congenital stapes ankylosis, broad thumbs, and hyperopia: report of a family and refinement of a syndrome by Milunsky, Jeff, Suntra, Charles, MacDonald, C. Bruce

“…We report on a family with conductive hearing loss due to congenital stapes ankylosis, and with hyperopia, broad thumbs, and broad first toes. Neither of the…”
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Reversible Sensorineural Hearing Loss Resulting from Hypertrophic Pachymeningitis in Systemic Lupus Erythematosus: A Case Report by Bullington, Molly, Davies, George, MacDonald, C Bruce

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Assessing tablet-sticking propensity: by weighing accumulated powder on a removable punch tip by Mullarney, Matthew P, MacDonald, Bruce C, Hutchins, Allan

“…The authors designed an upper punch with a removable punch tip to determine a tablet formulation's propensity to stick by weighing the mass of powder adhered…”
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Inner ear volumetric measurements using high-resolution 3D T2-weighted fast spin-echo MR imaging: initial experience in healthy subjects by Melhem, ER, Shakir, H, Bakthavachalam, S, MacDonald, CB, Gira, J, Caruthers, SD, Jara, H

“…Adult size is achieved in the inner ear labyrinth by approximately 25 weeks' gestation, and minimal variability in age, sex, side, and race is found after…”
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Factitious HIV infection in an otolaryngology patient by Bauer, Paul W, Macdonald, C Bruce, Stram, John R

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Allergic Reaction to Silver Oxide Impregnated Myringotomy Tubes by Shah, Udayan, Stram, John, Macdonald, C. Bruce

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