Search Results - "MacDonald, Alastair J."

Regulation of food intake by astrocytes in the brainstem dorsal vagal complex by MacDonald, Alastair J., Holmes, Fiona E., Beall, Craig, Pickering, Anthony E., Ellacott, Kate L. J.

“…A role for glial cells in brain circuits controlling feeding has begun to be identified with hypothalamic astrocyte signaling implicated in regulating energy…”
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Combining routine outcomes measurement and 'Payment by Results': will it work and is it worth it? by Macdonald, Alastair J D, Elphick, Martin

“…The Department of Health in England has long encouraged the routine measurement of clinical outcomes in mental health services but has now decided to use…”
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Brain-Body Control of Glucose Homeostasis-Insights From Model Organisms by MacDonald, Alastair J, Yang, Yu Hsuan Carol, Cruz, Ana Miguel, Beall, Craig, Ellacott, Kate L J

“…Tight regulation of blood glucose is essential for long term health. Blood glucose levels are defended by the correct function of, and communication between,…”
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APOE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients by Adamis, Dimitrios, Treloar, Adrian, Martin, Finbarr C., Gregson, Norman, Hamilton, Gillian, Macdonald, Alastair J. D.

“…Background Delirium frequently occurs in the context of infection and other inflammatory conditions associated with elevated levels of cytokines. Cytokines…”
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Delirium scales: A review of current evidence by Adamis, Dimitrios, Sharma, Naveen, Whelan, Paul J.P., Macdonald, Alastair J.D.

“…Objectives: Delirium is a common neuropsychiatric condition with many adverse outcomes in elderly populations including death. Despite this, it is often…”
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Reliability of delirium rating scale (DRS) and delirium rating scale-revised-98 (DRS-R98) using variance-based multivariate modelling by Adamis, Dimitrios, Slor, Chantal J, Leonard, Maeve, Witlox, Joost, de Jonghe, Jos F.M, Macdonald, Alastair J.D, Trzepacz, Paula, Meagher, David

“…Abstract Delirium’s characteristic fluctuation in symptom severity complicates the assessment of test–retest reliability of scales using classical analyses,…”
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Mother and Baby Units matter: improved outcomes for both by Stephenson, Lucy A, Macdonald, Alastair J D, Seneviratne, Gertrude, Waites, Freddie, Pawlby, Susan

“…Mother and Baby Units (MBUs) are usually preferred by patients and clinicians. Current provision is limited, although expansion is in progress. To ensure…”
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The association of the dopamine transporter gene and the dopamine receptor 2 gene with delirium, a meta-analysis by van Munster, Barbara C., de Rooij, Sophia E.J.A., Yazdanpanah, Mojgan, Tienari, Pentti J., Pitkälä, Kaisu H., Osse, Robert J., Adamis, Dimitrios, Smit, Orla, van der Steen, Marijke S., van Houten, Miriam, Rahkonen, Terhi, Sulkava, Raimo, Laurila, Jouko V., Strandberg, Timo E., Tulen, Joke H.M., Zwang, Louwerens, MacDonald, Alastair J.D., Treloar, Adrian, Sijbrands, Eric J.G., Zwinderman, Aeilko H., Korevaar, Johanna C.

“…Delirium is the most common neuropsychiatric syndrome in elderly ill patients. Previously, associations between delirium and the dopamine transporter gene…”
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Astrocytes in the nucleus of the solitary tract: Contributions to neural circuits controlling physiology by MacDonald, Alastair J., Ellacott, Kate L.J.

“…The nucleus of the solitary tract (NTS) is the primary brainstem centre for the integration of physiological information from the periphery transmitted via the…”
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A brief review of the history of delirium as a mental disorder by Adamis, Dimitrios, Treloar, Adrian, Martin, Finbarr C., Macdonald, Alastair J.D.

“…We review the most important concepts about delirium, from ancient times until the twentieth century. We also focus on the question of how these concepts have…”
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Impact of chemogenetic activation of dorsal vagal complex astrocytes in mice on adaptive glucoregulatory responses by MacDonald, Alastair J., Pye, Katherine R., Beall, Craig, Ellacott, Kate L. J.

“…The dorsal vagal complex (DVC) regulates diverse aspects of physiology including food intake and blood glucose homeostasis. Astrocytes play an active role in…”
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Phenomenological and biological correlates of improved cognitive function in hospitalized elderly medical inpatients by Adamis, Dimitrios, Meagher, David, Treloar, Adrian, Dunne, Colum, Larvin, Michael, Martin, Finbarr C, Macdonald, Alastair J.D

“…Abstract Deterioration of cognitive ability is a recognized outcome following acute illness in older patients. Levels of circulating cytokines and APOE…”
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Astrocytes in neuroendocrine systems: An overview by MacDonald, Alastair J., Robb, Josephine L., Morrissey, Nicole A., Beall, Craig, Ellacott, Kate L. J.

“…A class of glial cell, astrocytes, is highly abundant in the central nervous system (CNS). In addition to maintaining tissue homeostasis, astrocytes regulate…”
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Ethical Research in Delirium: Arguments for Including Decisionally Incapacitated Subjects by Adamis, Dimitrios, Treloar, Adrian, Martin, Finbarr C., Macdonald, Alastair J. D.

“…Here we describe how more important findings were obtained in a delirium study by using an informal assessment of mental capacity, and, in those who lacked…”
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Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients by Adamis, Dimitrios, Lunn, Mary, Martin, Finbarr C., Treloar, Adrian, Gregson, Norman, Hamilton, Gillian, Macdonald, Alastair J. D.

“…Background: therapeutic use of cytokines can induce delirium, and delirium often occurs during infections associated with elevated levels of cytokines. This…”
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The Performance of the Clock Drawing Test in Elderly Medical Inpatients: Does It Have Utility in the Identification of Delirium? by Adamis, Dimitrios, Morrison, Catriona, Treloar, Adrian, Macdonald, Alastair J. D., Martin, Finbarr C.

“…The Clock Drawing Test is an often-used test for the detection of cognitive impairment, but the few studies that have evaluated its utility in delirium have…”
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Implementation of outcome measurement (HoNOS) in an outpatient psychiatric clinic in Sligo/Leitrim mental health service by Sweeney, James, Adamis, Dimitrios, Helmi, Luqman, Macdonald, Alastair J. D.

“…Background Routine clinical outcome monitoring (RCOM) is the standardised gathering of measures of clinical outcomes in everyday practice. HoNOS (Health of the…”
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Routine mental health outcome measurement in the UK by Macdonald, Alastair J. D., Fugard, Andrew J. B.

“…This paper offers a short history of routine clinical outcomes measurement (RCOM) in UK mental health services. RCOM developments in primary and secondary care…”
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Courage, Fear and the Experience of the Later Medieval Scottish Soldier by Macdonald, Alastair J

“…This article examines aspects of the experience of the later medieval Scottish soldier, in particular courage, fear and the factors that shaped these…”
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Dysgraphia in elderly delirious medical inpatients by Adamis, Dimitrios, Reich, Shuli, Treloar, Adrian, Macdonald, Alastair J, Martin, Finbarr C

“…Dysgraphia is a recognized clinical finding in delirium, but few studies have evaluated handwriting, and results have been inconsistent. In particular,…”
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