Search Results - "MacDonagh, Lauren"

Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways by Leon, Gemma, MacDonagh, Lauren, Finn, Stephen P, Cuffe, Sinead, Barr, Martin P

“…Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-cancer therapies such as chemotherapy, radiotherapy and targeted…”
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The emerging role of microRNAs in resistance to lung cancer treatments by MacDonagh, Lauren, Gray, Steven G, Finn, Stephen P, Cuffe, Sinead, O’Byrne, Kenneth J, Barr, Martin P

“…Highlights • MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally control the translation and stability of mRNAs. • It has been predicted…”
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Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin by MacDonagh, Lauren, Santiago, Rhyla Mae, Gray, Steven G., Breen, Eamon, Cuffe, Sinead, Finn, Stephen P., O'Byrne, Kenneth J., Barr, Martin P.

“…•All-trans retinoic acid (ATRA) and retinol significantly reduced ALDH1+ve cell subsets.•Co-treatment of ATRA or retinol with cisplatin significantly inhibited…”
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When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All? by Baird, Anne-Marie, Easty, David, Jarzabek, Monika, Shiels, Liam, Soltermann, Alex, Klebe, Sonja, Raeppel, Stéphane, MacDonagh, Lauren, Wu, Chengguang, Griggs, Kim, Kirschner, Michaela B, Stanfill, Bryan, Nonaka, Daisuke, Goparaju, Chandra M, Murer, Bruno, Fennell, Dean A, O'Donnell, Dearbhaile M, Barr, Martin P, Mutti, Luciano, Reid, Glen, Finn, Stephen, Cuffe, Sinead, Pass, Harvey I, Opitz, Isabelle, Byrne, Annette T, O'Byrne, Kenneth J, Gray, Steven G

“…Malignant pleural mesothelioma (MPM) is an aggressive inflammatory cancer with a poor survival rate. Treatment options are limited at best and drug resistance…”
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Lung cancer stem cells: The root of resistance by MacDonagh, Lauren, Gray, Steven G, Breen, Eamon, Cuffe, Sinead, Finn, Stephen P, O'Byrne, Kenneth J, Barr, Martin P

“…Highlights • Therapeutic resistance and tumor recurrence is common in lung cancer. • Cancer stem cells (CSCs) have the ability to self-renew and differentiate…”
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BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC by MacDonagh, Lauren, Gray, Steven G., Breen, Eamon, Cuffe, Sinead, Finn, Stephen P., O'Byrne, Kenneth J., Barr, Martin P.

“…Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide. While partial or complete tumor regression can be achieved in…”
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Efficacy and adherence of noninvasive ventilation treatment in children with Down syndrome by MacDonagh, Lauren, Farrell, Lisa, O'Reilly, Ruth, McNally, Paul, Javadpour, Sheila, Cox, Des W.

“…Objective Children with Down syndrome (DS) have an increased prevalence of obstructive sleep apnea (OSA). Noninvasive ventilation (NIV) is a common modality of…”
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Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC by MacDonagh, Lauren, Gallagher, Michael F, Ffrench, Brendan, Gasch, Claudia, Breen, Eamon, Gray, Steven G, Nicholson, Siobhan, Leonard, Niamh, Ryan, Ronan, Young, Vincent, O'Leary, John J, Cuffe, Sinead, Finn, Stephen P, O'Byrne, Kenneth J, Barr, Martin P

“…Non-small cell lung cancer (NSCLC) accounts for a large proportion of cancer deaths and is characterized by low treatment response rates and poor overall…”
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Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma by Cregan, Sian, Breslin, Maeve, Roche, Gerard, Wennstedt, Sigrid, MacDonagh, Lauren, Albadri, Cinaria, Gao, Yun, O'Byrne, Kenneth J, Cuffe, Sinead, Finn, Stephen P, Gray, Steven G

“…Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The current standard of…”
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MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer by MacDonagh, Lauren, Gallagher, Michael F., Ffrench, Brendan, Gasch, Claudia, Gray, Steven G., Reidy, Marie, Nicholson, Siobhan, Leonard, Niamh, Ryan, Ronan, Young, Vincent, O’Leary, John J., Cuffe, Sinead, Finn, Stephen P., O’Byrne, Kenneth J., Barr, Martin P.

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