Search Results - "MacDermot, J"

The molecular mechanisms of drug action by MacDermot, J

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The N-terminal thrombin receptor fragment SFLLRN, but not catalytically inactive thrombin-derived agonists, activate U937 human monocytic cells : evidence for receptor hydrolysis in thrombin-dependent signalling by JOSEPH, S, MACDERMOT, J

“…It has previously been reported that murine macrophages can respond chemotactically and mitogenically to the serine proteinase thrombin. There is a similar…”
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Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro by WILSON, R, PITT, T, TAYLOR, G, WATSON, D, MACDERMOT, J, SYKES, D, ROBERTS, D, COLE, P

“…Pseudomonas aeruginosa culture filtrates varied in their ability to slow human ciliary beat frequency (7-71%). This activity did not correlate with known…”
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Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells : analysis of the signalling mechanisms mediating actin polymerization by JOSEPH, S, MACDERMOT, J

“…The U937 human monocyte-macrophage cell line was used to examine the effect of thrombin, an ill-defined chemoattractant, on the polymerization of actin, a…”
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Inhibition of chemotaxis in A7r5 rat smooth muscle cells by a novel panel of inhibitors by Saxty, B A, Yadollahi‐Farsani, M, Kefalas, P, Paul, S, MacDermot, J

“…1 Arginine‐specific ADP‐ribosyltransferase (ART) activity has been implicated in white cell chemotaxis. In this study, we examined the capacity of a panel of…”
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Arginine-specific ADP-ribosyltransferases in leukocytes by Saxty, B A, Kefalas, P, Yadollahi-Farsani, M, MacDermot, J

“…The posttranslational modification of proteins by the addition of an ADP‐ribose group is mediated by ADP‐ribosyltransferases, which are expressed widely in…”
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Human calcitonin gene‐related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells by Crossman, D., McEwan, J., MacDermot, J., MacIntyre, I., Dollery, C.T.

“…1 Endothelial cells of human umbilical vein were isolated and cultured in vitro. 2 In these cells there was a concentration‐dependent release of prostacyclin…”
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Differential sensitivities of the prostacyclin and nitric oxide biosynthetic pathways to cytosolic calcium in bovine aortic endothelial cells by Parsaee, Heydar, McEwan, Jean R., Joseph, Sunil, MacDermot, John

“…1 Bovine aortic endothelial cells were cultured in vitro, and shown to release both prostacyclin (PGI2; Kact = 24.1 nm) and endothelium‐derived relaxing factor…”
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Reduction by inhibitors of mono(ADP‐ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin by Allport, Jennifer R., Donnelly, Louise E., Hayes, Brian P., Murray, Stephen, Rendell, Nigel B., Ray, Keith P., MacDermot, John

“…1 Chemotaxis of human neutrophils is mediated by numerous agents [e.g. N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP) and platelet activating factor (PAF)]…”
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Phorbol ester enhances activation of adenylate cyclase in bovine aortic endothelial cells by Lefroy, D C, Donnelly, L E, McEwan, J R, MacDermot, J

“…Endothelial cells possess beta-adrenoceptors linked to adenylate cyclase which may regulate several aspects of endothelial cell function. The potential for…”
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IgE and IgG are synergistic in antigen-mediated release of thromboxane from human lung macrophages by Storch, J, MacDermot, J

“…The mechanism of IgE-mediated release of thromboxane A2 from human lung macrophages has been studied using a monoclonal chimeric human/mouse IgE antibody and…”
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A physiology classic revisited after 60 years by Al-Mohammad, A, Scott, J, Beatt, K J, MacDermot, J

“…Harry Goldblatt worked on the theory that all cases of raised blood pressure were secondary to renal ischaemia. An unusual sequence of events that recreates…”
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Guanine nucleotide sensitivity of [3H]iloprost binding to prostacyclin receptors by Keen, M, Kelly, E, MacDermot, J

“…A component of the displaceable binding of the stable prostacyclin analogue, [3H]iloprost, to membranes from human platelets and the somatic hybrid cell lines…”
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Identification of the prostacyclin receptor by radiation inactivation by Leigh, P J, Cramp, W A, MacDermot, J

“…Evidence has been obtained for a specific protein receptor for prostacyclin on cells of the NCB-20 somatic hybrid. A new stable prostacyclin analog,…”
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Increased pulmonary α -adrenergic and reduced β -adrenergic receptors in experimental asthma by Barnes, Peter J, Dollery, Colin T, MacDermot, J

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NaF and guanine nucleotides modulate adenylate cyclase activity in NG108‐15 cells by interacting with both Gs and Gi by Kelly, Eamonn, Keen, Mary, Nobbs, Peter, MacDermot, John

“…1 NaF (10 mm) produced a 2–3 fold increase in adenylate cyclase activity in homogenates of NG108‐15 cells incubated in the presence of 1 μm GTP. Higher…”
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Prostacyclin analogues reduce ADP‐ribosylation of the α‐subunit of the regulatory Gs‐protein and diminish adenosine (A2) responsiveness of platelets by Edwards, Robert J., MacDermot, John, Wilkins, Amanda J.

“…1 Prostacyclin and adenosine activate adenylate cyclase in human platelet membranes and inhibit platelet aggregation. Results are presented which show that…”
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Bradykinin‐induced release of PGI2 from aortic endothelial cell lines: responses mediated selectively by Ca2+ ions or a staurosporine‐sensitive kinase by Parsaee, Heydar, McEwan, Jean R., MacDermot, John

“…1 Bradykinin (100 nm) triggers release of nitric oxide and prostacyclin from both AG07680A and AG04762 bovine cultured aortic endothelial cells. The exposure…”
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Adenylate Cyclase and Acetylcholine Release Regulated by Separate Serotonin Receptors of Somatic Cell Hybrids by MacDermot, John, Higashida, Haruhiro, Wilson, Steven P., Matsuzawa, Hiroshi, Minna, John, Nirenberg, Marshall

“…Serotonin activates adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] of NCB-20 neuroblastoma-brain hybrid cells with an activation constant…”
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Octimibate, a potent non‐prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor by Merritt, Janet E., Hallam, Trevor J., Brown, Anthony M., Boyfield, Isobel, Cooper, David G., Hickey, Deirdre M.B., Jaxa‐Chamiec, Albert A., Kaumann, Alberto J., Keen, Mary, Kelly, Eamonn, Kozlowski, Ursula, Lynham, James A., Moores, Kitty E., Murray, Kenneth J., MacDermot, John, Rink, Timothy J.

“…1 Octimibate, 8‐[(1,4,5‐triphenyl‐1H‐imidazol‐2‐yl)oxy]octanoic acid, is reported to have antithrombotic properties. This is in addition to its…”
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