Search Results - "MacCulloch, Tara"
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The influence of Holliday junction sequence and dynamics on DNA crystal self-assembly
Published in Nature communications (03-06-2022)“…The programmable synthesis of rationally engineered crystal architectures for the precise arrangement of molecular species is a foundational goal in…”
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2
Proximity-enhanced synthesis of DNA-peptide-DNA triblock molecules
Published in Chemical communications (Cambridge, England) (24-03-2022)“…We report a proximity-enhanced method to synthesize a peptide flanked by two different oligonucleotide handles. Our method relies on sequential bioorthogonal…”
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A Self‐Assembled Rhombohedral DNA Crystal Scaffold with Tunable Cavity Sizes and High‐Resolution Structural Detail
Published in Angewandte Chemie International Edition (12-10-2020)“…DNA is an ideal molecule for the construction of 3D crystals with tunable properties owing to its high programmability based on canonical Watson–Crick base…”
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4
Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals
Published in Journal of the American Chemical Society (16-08-2017)“…The foundational goal of structural DNA nanotechnologythe field that uses oligonucleotides as a molecular building block for the programmable self-assembly of…”
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5
High‐Affinity Host–Guest Recognition for Efficient Assembly and Enzymatic Responsiveness of DNA Nanostructures
Published in Small (Weinheim an der Bergstrasse, Germany) (01-03-2024)“…The combination of multiple orthogonal interactions enables hierarchical complexity in self‐assembled nanoscale materials. Here, efficient supramolecular…”
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6
Rational Design of Self-Assembling Crystal Scaffolds and DNA-Peptide Hybrid Materials
Published 01-01-2021“…Since the conception of DNA nanotechnology, the field has evolved towards the development of complex, dynamic 3D structures. The predictability of Watson-Crick…”
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Dissertation -
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Site-Specific Arrangement and Structure Determination of Minor Groove Binding Molecules in Self-Assembled Three-Dimensional DNA Crystals
Published in Journal of the American Chemical Society (06-12-2023)“…The structural analysis of guest molecules in rationally designed and self-assembling DNA crystals has proven an elusive goal since its conception…”
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Protein Corona Inhibits Endosomal Escape of Functionalized DNA Nanostructures in Living Cells
Published in ACS applied materials & interfaces (06-10-2021)“…DNA nanostructures (DNs) can be designed in a controlled and programmable manner, and these structures are increasingly used in a variety of biomedical…”
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9
Structure of a self-assembled three-dimensional DNA crystal framework for the precise organization of biomaterials
Published in Acta crystallographica. Section A, Foundations and advances (20-07-2019)“…Abstract only…”
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10
Enantiomeric structures of a self-assembling three-dimensional DNA crystal scaffold
Published in Acta crystallographica. Section A, Foundations and advances (26-05-2017)“…Abstract only…”
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11
A Self‐Assembled Rhombohedral DNA Crystal Scaffold with Tunable Cavity Sizes and High‐Resolution Structural Detail
Published in Angewandte Chemie (12-10-2020)“…DNA is an ideal molecule for the construction of 3D crystals with tunable properties owing to its high programmability based on canonical Watson–Crick base…”
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Journal Article -
12
Uncovering temporospatial sensitive TBI targeting strategies via in vivo phage display
Published in Science advances (22-07-2022)“…The heterogeneous pathophysiology of traumatic brain injury (TBI) is a barrier to advancing diagnostics and therapeutics, including targeted drug delivery. We…”
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