Search Results - "MacCraith, Brian"

Optical Chemical Sensors by McDonagh, Colette, Burke, Conor S, MacCraith, Brian D

“…New developments in optical chemical sensors are examined, and an overview of developments in absorption-and-luminescence-based sensors is presented. The…”
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Multisubstrate-compatible ELISA procedures for rapid and high-sensitivity immunoassays by MacCraith, Brian D, O'Kennedy, Richard, Vashist, Sandeep Kumar, Dixit, Chandra Kumar

“…This protocol describes an improved and optimized approach to develop rapid and high-sensitivity ELISAs by covalently immobilizing antibody on chemically…”
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Effect of antibody immobilization strategies on the analytical performance of a surface plasmon resonance-based immunoassay by Vashist, Sandeep Kumar, Dixit, Chandra Kumar, MacCraith, Brian D, O'Kennedy, Richard

“…Antibody immobilization strategies (random, covalent, orientated and combinations of each) were examined to determine their performance in a surface plasmon…”
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Development of a High Sensitivity Rapid Sandwich ELISA Procedure and Its Comparison with the Conventional Approach by Dixit, Chandra Kumar, Vashist, Sandeep Kumar, O’Neill, Feidhlim T., O’Reilly, Brian, MacCraith, Brian D., O’Kennedy, Richard

“…A highly sensitive and rapid sandwich enzyme-linked immunosorbent assay (ELISA) procedure was developed for the detection of human fetuin A/AHSG…”
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Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications by Galvin, Paul, Thompson, Damien, Ryan, Katie B., McCarthy, Anna, Moore, Anne C., Burke, Conor S., Dyson, Maya, MacCraith, Brian D., Gun’ko, Yurii K., Byrne, Michelle T., Volkov, Yuri, Keely, Chris, Keehan, Enda, Howe, Michael, Duffy, Conor, MacLoughlin, Ronan

“…Nanoparticles (NPs) comprised of nanoengineered complexes are providing new opportunities for enabling targeted delivery of a range of therapeutics and…”
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Immobilization of Biomolecules on Cycloolefin Polymer Supports by Laib, Stephan, MacCraith, Brian D

“…Recent trends in the development of microfluidic and biodiagnostic chips favor polymer materials over glass, primarly for optical and economical reasons…”
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Signal enhancement of surface plasmon-coupled emission (SPCE) with the evanescent field of surface plasmons on a bimetallic paraboloid biochip by Yuk, Jong Seol, MacCraith, Brian D., McDonagh, Colette

“…We present a novel approach to the enhancement of surface plasmon-coupled emission (SPCE) using surface plasmon excitation in a bimetal (Ag/Au) layer and we…”
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Surface plasmon-coupled emission (SPCE)-based immunoassay using a novel paraboloid array biochip by Yuk, Jong Seol, Trnavsky, Michal, McDonagh, Colette, MacCraith, Brian D.

“…We have carried out a human IgG immunoassay on a novel disposable optical array biochip using surface plasmon-coupled emission (SPCE) detection. The work…”
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Enhancing the analytical performance of immunoassays that employ metal-enhanced fluorescence by Nooney, Robert, Clifford, Andrew, LeGuevel, Xavier, Stranik, Ondrej, McDonagh, Colette, MacCraith, Brian D

“…In this work, we used a model assay system (polyclonal human IgG-goat antihuman IgG) to elucidate some of the key factors that influence the analytical…”
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Optimization of Plasmonic Enhancement of Fluorescence on Plastic Substrates by Nooney, Robert I, Stranik, Ondrej, McDonagh, Colette, MacCraith, Brian D

“…In this work, we report on the uniform deposition of tailored plasmonic coatings on polymer substrates and on the distance dependence of the plasmonic…”
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Fluorescence Lifetime Analysis and Fluorescence Correlation Spectroscopy Elucidate the Internal Architecture of Fluorescent Silica Nanoparticles by Roy, Shibsekhar, Woolley, Robert, MacCraith, Brian D, McDonagh, Colette

“…Fluorescence lifetime (FL) analysis and fluorescence correlation spectroscopy (FCS) have been successfully employed to reveal detailed information about the…”
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Synthesis, Stabilization, and Functionalization of Silver Nanoplates for Biosensor Applications by Le Guével, Xavier, Wang, Freddy Y, Stranik, Ondrej, Nooney, Robert, Gubala, Vladimir, McDonagh, Colette, MacCraith, Brian D

“…Silver nanoplates (NPTs) were prepared by a seed-mediated growth method with different diameters (d = 25, 32, 53, and 100 nm) and with thicknesses of…”
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A comparison of mono and multivalent linkers and their effect on the colloidal stability of nanoparticle and immunoassays performance by Gubala, Vladimir, Le Guevel, Xavier, Nooney, Rob, Williams, David E., MacCraith, Brian

“…When designing devices for biomedical diagnostics, increasing the signal to noise ratio is often critical for achieving clinically relevant sensitivity and…”
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Demonstration of a surface plasmon-coupled emission (SPCE)-based immunoassay in the absence of a spacer layer by Yuk, Jong Seol, McDonagh, Colette, MacCraith, Brian D

“…The technique of surface plasmon-coupled emission (SPCE) involves the coupling of light which is emitted from a fluorophore into the surface plasmon of an…”
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Novel Multiparametric Approach to Elucidate the Surface Amine-Silanization Reaction Profile on Fluorescent Silica Nanoparticles by Roy, Shibsekhar, Dixit, Chandra K, Woolley, Robert, MacCraith, Brian D, O’Kennedy, Richard, McDonagh, Colette

“…This Article addresses the important issue of the characterization of surface functional groups for optical bioassay applications. We use a model system…”
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Evaluation of apparent non-specific protein loss due to adsorption on sample tube surfaces and/or altered immunogenicity by Dixit, Chandra K, Vashist, Sandeep K, MacCraith, Brian D, O'Kennedy, Richard

“…The non-specific loss of protein analytes can have a major effect on assay results particularly where the concentrations of such analytes are extremely low and…”
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Surface immobilisation of antibody on cyclic olefin copolymer for sandwich immunoassay by Raj, Jog, Herzog, Grégoire, Manning, Mary, Volcke, Cédric, MacCraith, Brian D., Ballantyne, Scott, Thompson, Michael, Arrigan, Damien W.M.

“…In this work, the surface functionalisation of the commercially available cyclic olefin copolymer (COC) materials, ZeonorR and ZeonexR, has been studied. The…”
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Silane-dextran chemistry on lateral flow polymer chips for immunoassays by Jönsson, Christina, Aronsson, Magnus, Rundström, Gerd, Pettersson, Christer, Mendel-Hartvig, Ib, Bakker, Jimmy, Martinsson, Erik, Liedberg, Bo, MacCraith, Brian, Ohman, Ove, Melin, Jonas

“…The prognosis for patients suffering from cardiovascular and many other diseases can be substantially improved if diagnosed at an early stage. High performance…”
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Nanoparticle strategies for enhancing the sensitivity of fluorescence-based biochips by McDonagh, Colette, Stranik, Ondrej, Nooney, Robert, Maccraith, Brian D

“…This article describes strategies for achieving fluorescence enhancement in optical biochips. Two strategies are discussed: plasmonic enhancement, which is due…”
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Kinetics of immunoassays with particles as labels: effect of antibody coupling using dendrimers as linkers by Gubala, Vladimir, Lynam, Carol Crean née, Nooney, Robert, Hearty, Stephen, McDonnell, Barry, Heydon, Katherine, O'Kennedy, Richard, MacCraith, Brian D, Williams, David E

“…In this article, we report on poly(amidoamine) dendrimers (PAMAM) as coupling agents for recombinant single-chain (ScFv) antibodies to nanoparticle (NP)…”
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