Search Results - "MacArtney, Thomas J."

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters by de Los Heros, Paola, Alessi, Dario R, Gourlay, Robert, Campbell, David G, Deak, Maria, Macartney, Thomas J, Kahle, Kristopher T, Zhang, Jinwei

“…Precise homoeostasis of the intracellular concentration of Cl- is achieved via the co-ordinated activities of the Cl- influx and efflux. We demonstrate that…”
Get more information

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 by Kondapalli, Chandana, Kazlauskaite, Agne, Zhang, Ning, Woodroof, Helen I., Campbell, David G., Gourlay, Robert, Burchell, Lynn, Walden, Helen, Macartney, Thomas J., Deak, Maria, Knebel, Axel, Alessi, Dario R., Muqit, Miratul M. K.

“…Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that…”
Get full text

Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases by Castor, Dennis, Nair, Nidhi, Déclais, Anne-Cécile, Lachaud, Christophe, Toth, Rachel, Macartney, Thomas J, Lilley, David M J, Arthur, J Simon C, Rouse, John

“…Holliday junctions (HJs) are X-shaped DNA structures that arise during homologous recombination, which must be removed to enable chromosome segregation. The…”
Get full text

Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System by Simpson, Luke M, Macartney, Thomas J, Nardin, Alice, Fulcher, Luke J, Röth, Sascha, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Ganley, Ian G, Sapkota, Gopal P

“…The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3…”
Get more information

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction by Ohta, Akihito, Schumacher, Frances-Rose, Mehellou, Youcef, Johnson, Clare, Knebel, Axel, Macartney, Thomas J, Wood, Nicola T, Alessi, Dario R, Kurz, Thimo

“…The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an…”
Get more information

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage by Davis, Emily J, Lachaud, Christophe, Appleton, Paul, Macartney, Thomas J, Näthke, Inke, Rouse, John

“…The AAA ATPase p97 (VCP) is thought to remove specific proteins from chromatin at sites of DNA damage, to allow proper repair or processing, but how p97…”
Get full text

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1 by Lai, Yu-Chiang, Kondapalli, Chandana, Lehneck, Ronny, Procter, James B, Dill, Brian D, Woodroof, Helen I, Gourlay, Robert, Peggie, Mark, Macartney, Thomas J, Corti, Olga, Corvol, Jean-Christophe, Campbell, David G, Itzen, Aymelt, Trost, Matthias, Muqit, Miratul MK

“…Mutations in the PTEN‐induced kinase 1 (PINK1) are causative of autosomal recessive Parkinson's disease (PD). We have previously reported that PINK1 is…”
Get full text

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling by Bustos, Francisco, Segarra-Fas, Anna, Nardocci, Gino, Cassidy, Andrew, Antico, Odetta, Davidson, Lindsay, Brandenburg, Lennart, Macartney, Thomas J., Toth, Rachel, Hastie, C. James, Moran, Jennifer, Gourlay, Robert, Varghese, Joby, Soares, Renata F., Montecino, Martin, Findlay, Greg M.

“…Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental…”
Get full text

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms by Fulcher, Luke J, Bozatzi, Polyxeni, Tachie-Menson, Theresa, Wu, Kevin Z L, Cummins, Timothy D, Bufton, Joshua C, Pinkas, Daniel M, Dunbar, Karen, Shrestha, Sabin, Wood, Nicola T, Weidlich, Simone, Macartney, Thomas J, Varghese, Joby, Gourlay, Robert, Campbell, David G, Dingwell, Kevin S, Smith, James C, Bullock, Alex N, Sapkota, Gopal P

“…Members of the casein kinase 1 (CK1) family of serine-threonine protein kinases are implicated in the regulation of many cellular processes, including the cell…”
Get more information

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2 by MacKay, Craig, Déclais, Anne-Cécile, Lundin, Cecilia, Agostinho, Ana, Deans, Andrew J., MacArtney, Thomas J., Hofmann, Kay, Gartner, Anton, West, Stephen C., Helleday, Thomas, Lilley, David M.J., Rouse, John

“…DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of replisomes. The Fanconi Anemia (FA) proteins, encoded by genes that…”
Get full text

Targeting endogenous proteins for degradation through the affinity-directed protein missile system by Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Turnbull, Craig, Sapkota, Gopal P.

“…Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and…”
Get full text

A novel FAM83G variant from palmoplantar keratoderma patient disrupts WNT signalling via loss of FAM83G-CK1α interaction by Glennie, Lorraine, Solà, Marta Codina, Xunclà, Mar, Español, Gloria Aparicio, Garcia-Arumí, Elena, Tizzano, Eduardo Fidel, Wood, Nicola T, Macartney, Thomas J, Lasa-Aranzasti, Amaia, Sapkota, Gopal P

“…Palmoplantar keratoderma (PPK) is a multi-faceted skin disorder characterized by the thickening of the epidermis and abrasions on the palms and soles of the…”
Get full text

Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA by Brewer, Abigail, Sathe, Gajanan, Pflug, Billie E., Clarke, Rosemary G., Macartney, Thomas J., Sapkota, Gopal P.

“…Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic…”
Get full text

Targeted dephosphorylation of TFEB promotes its nuclear translocation by Zhao, Jin-Feng, Shpiro, Natalia, Sathe, Gajanan, Brewer, Abigail, Macartney, Thomas J., Wood, Nicola T., Negoita, Florentina, Sakamoto, Kei, Sapkota, Gopal P.

“…Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and…”
Get full text

Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling by Brewer, Abigail, Zhao, Jin-Feng, Fasimoye, Rotimi, Shpiro, Natalia, Macartney, Thomas J., Wood, Nicola T., Wightman, Melanie, Alessi, Dario R., Sapkota, Gopal P.

“…TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases,…”
Get full text

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction by van der Wijst, Jenny, Blanchard, Maxime G, Woodroof, Helen I, Macartney, Thomas J, Gourlay, Robert, Hoenderop, Joost G, Bindels, René J, Alessi, Dario R

“…Mutations in the gene that encodes the atypical channel-kinase TRPM6 (transient receptor potential melastatin 6) cause HSH (hypomagnesaemia with secondary…”
Get more information

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling by Wu, Kevin Z L, Jones, Rebecca A, Tachie-Menson, Theresa, Macartney, Thomas J, Wood, Nicola T, Varghese, Joby, Gourlay, Robert, Soares, Renata F, Smith, James C, Sapkota, Gopal P

“…Two recessive mutations in the gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with…”
Get full text

A conserved ATG2‐GABARAP family interaction is critical for phagophore formation by Bozic, Mihaela, van den Bekerom, Luuk, Milne, Beth A, Goodman, Nicola, Roberston, Lisa, Prescott, Alan R, Macartney, Thomas J, Dawe, Nina, McEwan, David G

“…The intracellular trafficking pathway, macroautophagy, is a recycling and disposal service that can be upregulated during periods of stress to maintain…”
Get full text

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling by Wu, Kevin Z.L., Jones, Rebecca A., Tachie-Menson, Theresa, Macartney, Thomas J., Wood, Nicola T., Varghese, Joby, Gourlay, Robert, Soares, Renata F., Smith, James C., Sapkota, Gopal P.

“…Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are…”
Get full text

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning by Fulcher, Luke J, He, Zhengcheng, Mei, Lin, Macartney, Thomas J, Wood, Nicola T, Prescott, Alan R, Whigham, Arlene J, Varghese, Joby, Gourlay, Robert, Ball, Graeme, Clarke, Rosemary, Campbell, David G, Maxwell, Christopher A, Sapkota, Gopal P

“…The concerted action of many protein kinases helps orchestrate the error‐free progression through mitosis of mammalian cells. The roles and regulation of some…”
Get full text