Search Results - "Mac Nab, Paul"
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Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2
Published in Cardiovascular diabetology (06-05-2020)“…The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is…”
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Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation
Published in Frontiers in pharmacology (23-04-2021)“…Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation…”
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Rho‐kinase pathway activation and apoptosis in circulating leucocytes in patients with heart failure with reduced ejection fraction
Published in Journal of cellular and molecular medicine (01-01-2020)“…Background Increased Rho‐kinase activity in circulating leucocytes is observed in heart failure with reduced ejection fraction (HFrEF). However, there is…”
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The boundaries of mild chronic obstructive pulmonary disease (COPD): design of the searching clinical COPD onset (SOON) study
Published in BMJ open (01-08-2017)“…IntroductionClinical onset of chronic obstructive pulmonary disease (COPD) is the point at which the disease is first identifiable by physicians. It is a…”
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SIGNIFICANT DOWN-STREAM ACTIVATION OF THE RHO A/ RHO KINASE INTRACELLULAR SIGNALING PATHWAY IN PATIENTS WITH TYPE 2 DIABETES AND HYPERTENSION
Published in Journal of the American College of Cardiology (05-04-2016)“…Methods cross sectional study in consecutive patients with HT2DM under treatment for both conditions and normal renal function (n = 19, mean age = 61,2 years,…”
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