Search Results - "Macůrek, Libor"

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery by Macůrek, Libor, Lindqvist, Arne, Lim, Dan, Lampson, Michael A., Klompmaker, Rob, Freire, Raimundo, Clouin, Christophe, Taylor, Stephen S., Yaffe, Michael B., Medema, René H.

“…Cell division: PLK1 and aurora A at the checkpoint Polo-like kinase-1 (PLK1) is an essential mitotic kinase regulating multiple aspects of the cell division…”
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Bora and Aurora-A continue to activate Plk1 in mitosis by Bruinsma, Wytse, Macurek, Libor, Freire, Raimundo, Lindqvist, Arne, Medema, René H

“…Polo-like kinase-1 (Plk1) is required for proper cell division. Activation of Plk1 requires phosphorylation on a conserved threonine in the T-loop of the…”
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Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly by Tanenbaum, Marvin E, Macůrek, Libor, Galjart, Niels, Medema, René H

“…Bipolar spindle assembly critically depends on the microtubule plus‐end‐directed motor Eg5 that binds antiparallel microtubules and slides them in opposite…”
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C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress by Klebanovych, Anastasiya, Vinopal, Stanislav, Dráberová, Eduarda, Sládková, Vladimíra, Sulimenko, Tetyana, Sulimenko, Vadym, Vosecká, Věra, Macůrek, Libor, Legido, Agustin, Dráber, Pavel

“…ER distribution depends on microtubules, and ER homeostasis disturbance activates the unfolded protein response resulting in ER remodeling. CDK5RAP3 (C53)…”
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Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases by Sulimenko, Vadym, Dráberová, Eduarda, Sulimenko, Tetyana, Macurek, Libor, Richterová, Vera, Dráber, Petr, Dráber, Pavel

“…Aggregation of the high-affinity IgE receptors (FcepsilonRIs) on the surface of granulated mast cells initiates a chain of signaling events culminating in the…”
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Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6 by Macůrek, Libor

“…Cyclin-dependent kinases (CDKs) are master regulators of proliferation, and therefore they represent attractive targets for cancer therapy. Deve-lopment of…”
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Hematopoietic stem cell fate under the influence of Ser/Thr protein phosphatases by Alberich-Jorda, Meritxell, Macurek, Libor

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Targeting the Checkpoint to Kill Cancer Cells by Benada, Jan, Macurek, Libor

“…Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell…”
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CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate by Stolarova, Lenka, Kleiblova, Petra, Janatova, Marketa, Soukupova, Jana, Zemankova, Petra, Macurek, Libor, Kleibl, Zdenek

“…Germline alterations in many genes coding for proteins regulating DNA repair and DNA damage response (DDR) to DNA double-strand breaks (DDSB) have been…”
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WIP1 phosphatase as pharmacological target in cancer therapy by Pecháčková, Soňa, Burdová, Kamila, Macurek, Libor

“…DNA damage response (DDR) pathway protects cells from genome instability and prevents cancer development. Tumor suppressor p53 is a key molecule that…”
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Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly by Tanenbaum, Marvin E., Macůrek, Libor, Janssen, Aniek, Geers, Erica F., Alvarez-Fernández, Mónica, Medema, René H.

“…The formation of a bipolar spindle is an essential step during cell division. Bipolar spindle assembly is driven by the highly conserved microtubule motor Eg5…”
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Importance of Germline and Somatic Alterations in Human MRE11 , RAD50 , and NBN Genes Coding for MRN Complex by Otahalova, Barbora, Volkova, Zuzana, Soukupova, Jana, Kleiblova, Petra, Janatova, Marketa, Vocka, Michal, Macurek, Libor, Kleibl, Zdenek

“…The , , and genes encode for the nuclear MRN protein complex, which senses the DNA double strand breaks and initiates the DNA repair. The MRN complex also…”
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Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3 by Pechackova, Sona, Burdova, Kamila, Benada, Jan, Kleiblova, Petra, Jenikova, Gabriela, Macurek, Libor

“…PP2C family serine/threonine phosphatase WIP1 acts as a negative regulator of the tumor suppressor p53 and is implicated in silencing of cellular responses to…”
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Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint by Kleiblova, Petra, Shaltiel, Indra A, Benada, Jan, Ševčík, Jan, Pecháčková, Soňa, Pohlreich, Petr, Voest, Emile E, Dundr, Pavel, Bartek, Jiri, Kleibl, Zdenek, Medema, René H, Macurek, Libor

“…The DNA damage response (DDR) pathway and its core component tumor suppressor p53 block cell cycle progression after genotoxic stress and represent an…”
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Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage by Moudry, Pavel, Lukas, Claudia, Macurek, Libor, Hanzlikova, Hana, Hodny, Zdenek, Lukas, Jiri, Bartek, Jiri

“…The cellular DNA damage response (DDR) machinery that maintains genomic integrity and prevents severe pathologies, including cancer, is orchestrated by…”
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WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors by Burdova, Kamila, Storchova, Radka, Palek, Matous, Macurek, Libor

“…Genotoxic stress triggers a combined action of DNA repair and cell cycle checkpoint pathways. Protein phosphatase 2C delta (referred to as WIP1) is involved in…”
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A Complex of Kif18b and MCAK Promotes Microtubule Depolymerization and Is Negatively Regulated by Aurora Kinases by Tanenbaum, Marvin E., Macurek, Libor, van der Vaart, Babet, Galli, Matilde, Akhmanova, Anna, Medema, René H.

“…Spindle assembly requires tight control of microtubule (MT) dynamics. This is dependent on a variety of MT binding proteins and their upstream regulators. The…”
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PPM1D activity promotes the replication stress caused by cyclin E1 overexpression by Martinikova, Andra S., Stoyanov, Miroslav, Oravetzova, Anna, Kok, Yannick P., Yu, Shibo, Dobrovolna, Jana, Janscak, Pavel, Vugt, Marcel, Macurek, Libor

“…Oncogene‐induced replication stress has been recognized as a major cause of genome instability in cancer cells. Increased expression of cyclin E1 caused by…”
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Phosphorylation of PLK3 Is Controlled by Protein Phosphatase 6 by Aquino Perez, Cecilia, Palek, Matous, Stolarova, Lenka, von Morgen, Patrick, Macurek, Libor

“…Polo-like kinases play essential roles in cell cycle control and mitosis. In contrast to other members of this kinase family, PLK3 has been reported to be…”
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Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma by Martinikova, Andra S, Burocziova, Monika, Stoyanov, Miroslav, Macurek, Libor

“…Genome integrity is protected by the cell-cycle checkpoints that prevent cell proliferation in the presence of DNA damage and allow time for DNA repair. The…”
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