Search Results - "Macías Perez, Martha Edith"
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In vitro and computational studies of natural products related to perezone as anti-neoplastic agents
Published in Biochimie (01-04-2020)“…Many natural phyto-products as perezone (Per) exhibit anti-cancer activities. Using experimental and computational studies, it was described that Poly…”
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Design of Two New Sulfur Derivatives of Perezone: In Silico Study Simulation Targeting PARP-1 and In Vitro Study Validation Using Cancer Cell Lines
Published in International journal of molecular sciences (01-01-2024)“…Poly-ADP-Ribose Polymerase (PARP-1) is an overexpressed enzyme in several carcinomas; consequently, the design of PARP-1 inhibitors has acquired special…”
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Ethers and esters derived from apocynin avoid the interaction between p47phox and p22phox subunits of NADPH oxidase: evaluation in vitro and in silico
Published in Bioscience reports (02-08-2013)“…NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•-), which reacts with NO (nitric oxide),…”
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Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase
Published in Biochemical pharmacology (15-02-2016)“…[Display omitted] Cucurbitacins are cytotoxic triterpenoid sterols isolated from plants. One of their earliest cellular effect is the aggregation of actin…”
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Anticancer mechanisms determination of L‐aminoacids compounds serie on MDA‐MB‐231 cell line TNBC
Published in The FASEB journal (01-04-2020)“…Abstract only…”
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In vitro and computational studies showed that perezone inhibits PARP-1 and induces changes in the redox state of K562 cells
Published in Archives of biochemistry and biophysics (15-08-2019)“…Cancer is one of the leading causes of morbidity and mortality worldwide. This disease is characterized by uncontrolled growth and proliferation of abnormal…”
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In silico studies to explain the interactions to inactivate NAPDH oxidase by apocynin and its dimmer
Published in The FASEB journal (01-04-2012)“…Abstract only NADPH oxidase has been considered a therapeutic target in hypertension disease due to superoxide anion (O2•‐) react with Nitric Oxide (NO)…”
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Ethers and esters derived from apocynin avoid the interaction between p47 phox and p22 phox subunits of NADPH oxidase: evaluation in vitro and in silico
Published in Bioscience reports (01-08-2013)“…NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•−), which reacts with NO (nitric oxide),…”
Get full text
Journal Article