Search Results - "Mabuchi, Miyuki"

Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs by Nakao, Syuhei, Mabuchi, Miyuki, Shimizu, Tadashi, Itoh, Yoshihiro, Takeuchi, Yuko, Ueda, Masahiro, Mizuno, Hiroaki, Shigi, Naoko, Ohshio, Ikumi, Jinguji, Kentaro, Ueda, Yuko, Yamamoto, Masatatsu, Furukawa, Tatsuhiko, Aoki, Shunji, Tsujikawa, Kazutake, Tanaka, Akito

“…A series of 1-aryl-3,4-substituted-1H-pyrazol-5-ol derivatives was synthesized and evaluated as prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors to obtain a…”
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Identification and purification of target protein using affinity resin bearing a photo-labile linker by Mabuchi, Miyuki, Shimizu, Tadashi, Haramura, Masayuki, Tanaka, Akito

“…[Display omitted] This Letter presents an effective method for the identification of target proteins of bioactive compounds such as drugs, natural products,…”
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Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506 by Mabuchi, Miyuki, Shimizu, Tadashi, Ueda, Masahiro, Mitamura, Kuniko, Ikegawa, Shigeo, Tanaka, Akito

“…[Display omitted] Solid materials for affinity resins bearing long PEG spacers between a functional group used for immobilization of a bio-active compound and…”
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DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain by Kanno, Takeshi, Tsuchiya, Ayako, Shimizu, Tadashi, Mabuchi, Miyuki, Tanaka, Akito, Nishizaki, Tomoyuki

“…Background/Aims: The linoleic acid derivative DCP-LA selectively and directly activates PKCε. The present study aimed at understanding the mechanism of…”
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Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614 by Minoura, Hideaki, Takeshita, Shigeru, Ita, Makoto, Hirosumi, Jiro, Mabuchi, Miyuki, Kawamura, Ikuo, Nakajima, Satoko, Nakayama, Osamu, Kayakiri, Hiroshi, Oku, Teruo, Ohkubo-Suzuki, Akiko, Fukagawa, Masao, Kojo, Hitoshi, Hanioka, Kenichi, Yamasaki, Noritsugu, Imoto, Takafumi, Kobayashi, Yoshinori, Mutoh, Seitaro

“…We evaluated antidiabetic effects of 3-(2,4-dichlorobenzyl)-2-methyl- N-(pentylsulfonyl)-3 H-benzimidazole-5-carboxamide (FK614), a benzimidazole derivative…”
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Synergistic combination effect of the PCA-1/ALKBH3 inhibitor HUHS015 on prostate cancer drugs in vitro and in vivo by Mabuchi, Miyuki, Tsujikawa, Kazutake, Tanaka, Akito

“…Prostate cancer antigen-1/ALKBH3, a DNA/RNA demethylase of 3-methylcytosine, 1-methyladenine (1-meA), and 6-meA, was found in prostate cancer as an important…”
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Selective degradation of splicing factor CAPERα by anticancer sulfonamides by Uehara, Taisuke, Minoshima, Yukinori, Sagane, Koji, Sugi, Naoko Hata, Mitsuhashi, Kaoru Ogawa, Yamamoto, Noboru, Kamiyama, Hiroshi, Takahashi, Kentaro, Kotake, Yoshihiko, Uesugi, Mai, Yokoi, Akira, Inoue, Atsushi, Yoshida, Taku, Mabuchi, Miyuki, Tanaka, Akito, Owa, Takashi

“…A series of sulfonamides induced the ubiquitin-mediated degradation of the U2AF-related splicing factor, coactivator of activating protein-1 and estrogen…”
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Effects of Lomerizine and Its Metabolite on Glioblastoma Cells by Uemichi, Yuki, Mabuchi, Miyuki, Tsuchiya, Natsumi, Yasuda, Seina, Nakao, Shuhei, Shimizu, Tadashi

“…Glioblastoma is an incurable cancer with limited treatment options and a low survival rate. Temozolomide is the standard marketed small-molecule agent for…”
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A Naphthalimide-Based Cd2+ Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions by Tsukamoto, Koji, Shimabukuro, Shota, Mabuchi, Miyuki, Maeda, Hatsuo

“…We have developed a novel naphthalimide‐based Cd2+ fluorescent probe (1), featuring almost no background response, high sensitivity and selectivity toward Cd2+…”
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Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor by Nakao, Syuhei, Mabuchi, Miyuki, Wang, Shenglan, Kogure, Yoko, Shimizu, Tadashi, Noguchi, Koichi, Tanaka, Akito, Dai, Yi

“…[Display omitted] A series of 31 resveratrol derivatives was designed, synthesized and evaluated for activation and inhibition of the TRPA1 channel. Most acted…”
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A Naphthalimide‐Based Cd 2+ Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET‐Promoters under Neutral Conditions by Tsukamoto, Koji, Shimabukuro, Shota, Mabuchi, Miyuki, Maeda, Hatsuo

“…We have developed a novel naphthalimide‐based Cd 2+ fluorescent probe ( 1 ), featuring almost no background response, high sensitivity and selectivity toward…”
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A Naphthalimide-Based Cd super(2+) Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions by Tsukamoto, Koji, Shimabukuro, Shota, Mabuchi, Miyuki, Maeda, Hatsuo

“…We have developed a novel naphthalimide-based Cd super(2+) fluorescent probe (1), featuring almost no background response, high sensitivity and selectivity…”
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Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo by Ueda, Masahiro, Shimizu, Tadashi, Mabuchi, Miyuki, Horiike, Kota, Kitae, Kaori, Hase, Hiroaki, Ueda, Yuko, Tsujikawa, Kazutake, Tanaka, Akito

“…Novel potent prostate cancer antigen-1 (PCA-1)/alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3) inhibitors both in vivo and in vivo were…”
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Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug by Shimizu, Tadashi, Yamaguchi, Keiko, Yamamoto, Momoka, Kurioka, Rina, Kino, Yukari, Matsunaga, Wataru, Nakao, Syuhei, Fukuhara, Hiroshi, Tanaka, Akito, Gotoh, Akinobu, Mabuchi, Miyuki

“…[Display omitted] We carried out structure-activity relationship study on anti-cancer effects of naftopidil (1) and its metabolites, resulted in identification…”
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Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model by Mabuchi, Miyuki, Ueda, Masahiro, Yoshida, Yuri, Horiike, Kota, Yamaoka, Kenta, Nakao, Syuhei, Shimizu, Tadashi, Ueda, Yuko, Tsujikawa, Kazutake, Tanaka, Akito

“…The inhibitory activities of docetaxel at a wide range of doses (0.1-10 mg/kg; subcutaneously (s.c.), once/week) in nude mice bearing a human prostate cancer…”
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Stimulation of Choleresis by Insulin-Like Growth Factor-I in Rats by KAWAMURA, IKUO, TAKESHITA, SHIGERU, FUSHIMI, MARIKO, MABUCHI, MIYUKI, SEKI, JIRO, TOMOI, MASAAKI, GOTO, TOSHIO

“…Insulin-like growth factor-I (IGF-I) is an endogenous growth factor which is mainly produced in the liver. The functions of IGF-I can be summarized as…”
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Selective degradation of splicing factor CAPER[alpha] by anticancer sulfonamides by Uehara, Taisuke, Minoshima, Yukinori, Sagane, Koji, Sugi, Naoko Hata, Mitsuhashi, Kaoru Ogawa, Yamamoto, Noboru, Kamiyama, Hiroshi, Takahashi, Kentaro, Kotake, Yoshihiko, Uesugi, Mai, Yokoi, Akira, Inoue, Atsushi, Yoshida, Taku, Mabuchi, Miyuki, Tanaka, Akito, Owa, Takashi

“…Target-protein degradation is an emerging field in drug discovery and development. In particular, the substrate-receptor proteins of the cullin-ubiquitin…”
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Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt by Mabuchi, Miyuki, Shimizu, Tadashi, Ueda, Masahiro, Sasakawa, Yuka, Nakao, Syuhei, Ueda, Yuko, Kawamura, Akio, Tsujikawa, Kazutake, Tanaka, Akito

“…Prostate cancer antigen (PCA)-1/AlkB homologue 3 (ALKBH3) has been identified as a clinically significant factor and siRNA of PCA-1 inhibits DU145…”
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A Naphthalimide-Based Cd(2+) Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions by Tsukamoto, Koji, Shimabukuro, Shota, Mabuchi, Miyuki, Maeda, Hatsuo

“…We have developed a novel naphthalimide-based Cd(2+) fluorescent probe (1), featuring almost no background response, high sensitivity and selectivity toward…”
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Selective elution of target protein from affinity resins by a simple reductant with a thiol group by Mabuchi, Miyuki, Haramura, Masayuki, Shimizu, Tadashi, Nishizaki, Tomoyuki, Tanaka, Akito

“…We have made a chance discovery of selective elution of a specific binding protein from affinity resins by mixing them with aqueous solutions of a widely used…”
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