Search Results - "Mabry, Donna"

Tremelimumab in Combination With Microwave Ablation in Patients With Refractory Biliary Tract Cancer by Xie, Changqing, Duffy, Austin G., Mabry‐Hrones, Donna, Wood, Bradford, Levy, Elliot, Krishnasamy, Venkatesh, Khan, Javed, Wei, Jun S., Agdashian, David, Tyagi, Manoj, Gangalapudi, Vineela, Fioravanti, Suzanne, Walker, Melissa, Anderson, Victoria, Venzon, David, Figg, William D., Sandhu, Milan, Kleiner, David E., Morelli, Maria Pia, Floudas, Charalampos S., Brar, Gagandeep, Steinberg, Seth M., Korangy, Firouzeh, Greten, Tim F.

“…Treatment options for patients with advanced biliary tract cancer are limited. Dysregulation of the immune system plays an important role in the pathogenesis…”
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Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer by Ma, Lichun, Heinrich, Sophia, Wang, Limin, Keggenhoff, Friederike L., Khatib, Subreen, Forgues, Marshonna, Kelly, Michael, Hewitt, Stephen M., Saif, Areeba, Hernandez, Jonathan M., Mabry, Donna, Kloeckner, Roman, Greten, Tim F., Chaisaingmongkol, Jittiporn, Ruchirawat, Mathuros, Marquardt, Jens U., Wang, Xin Wei

“…Intratumor heterogeneity may result from the evolution of tumor cells and their continuous interactions with the tumor microenvironment which collectively…”
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Phase I/II study of PexaVec in combination with immune checkpoint inhibition in refractory metastatic colorectal cancer by Monge, Cecilia, Xie, Changqing, Myojin, Yuta, Coffman, Kelley, Hrones, Donna Mabry, Wang, Sophie, Hernandez, Jonathan M, Wood, Bradford J, Levy, Elliot B, Juburi, Israa, Hewitt, Stephen M, Kleiner, David E, Steinberg, Seth M, Figg, William D, Redd, Bernadette, Homan, Philip, Cam, Maggie, Ruf, Benjamin, Duffy, Austin G, Greten, Tim F

“…BackgroundOncolytic immunotherapy represents a unique therapeutic platform for the treatment of cancer. Here, we evaluated the safety and efficacy of the…”
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VB-111 (ofranergene obadenovec) in combination with nivolumab in patients with microsatellite stable colorectal liver metastases: a single center, single arm, phase II trial by Coffman-D'Annibale, Kelley, Myojin, Yuta, Monge, Cecilia, Xie, Changqing, Hrones, Donna Mabry, Wood, Bradford J, Levy, Elliot B, Kleiner, David, Figg, William Douglas, Steinberg, Seth M, Redd, Bernadette, Greten, Tim F

“…BackgroundMicrosatellite stable colorectal liver metastases (MSS CLM) maintain an immunosuppressive tumor microenvironment (TME). Historically, immune-based…”
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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma by Greten, Tim F, Abou-Alfa, Ghassan K, Cheng, Ann-Lii, Duffy, Austin G, El-Khoueiry, Anthony B., Finn, Richard S, Galle, Peter R, Goyal, Lipika, He, Aiwu Ruth, Kaseb, Ahmed O, Kelley, Robin Kate, Lencioni, Riccardo, Lujambio, Amaia, Mabry Hrones, Donna, Pinato, David J, Sangro, Bruno, Troisi, Roberto I, Wilson Woods, Andrea, Yau, Thomas, Zhu, Andrew X, Melero, Ignacio

“…Patients with advanced hepatocellular carcinoma (HCC) have historically had few options and faced extremely poor prognoses if their disease progressed after…”
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A Phase II Study of Pembrolizumab in Combination with Capecitabine and Oxaliplatin with Molecular Profiling in Patients with Advanced Biliary Tract Carcinoma by Monge, Cecilia, Pehrsson, Erica C, Xie, Changqing, Duffy, Austin G, Mabry, Donna, Wood, Bradford J, Kleiner, David E, Steinberg, Seth M, Figg, William D, Redd, Bernadette, Budhu, Anuradha, Wang, Sophie, Tandon, Mayank, Ma, Lichun, Wei Wang, Xin, Greten, Tim F

“…We conducted a phase II study of the combination of pembrolizumab with capecitabine and oxaliplatin (CAPOX) in patients with advanced biliary tract carcinoma…”
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Tremelimumab in combination with microwave ablation in patients with refractory biliary tract cancer (BTC) by Xie, Changqing, Fioravanti, Suzanne, Walker, Melissa, Mabry, Donna, Kleiner, David E, Wood, Brad J., Levy, Elliot B, Krishnasamy, Venkatesh P, Steinberg, Seth M., Duffy, Austin G., Greten, Tim F.

“…Abstract only 365 Background: Treatment option for patients with advanced BTC is limited and prognosis is poor with a median survival of less than 1 year in…”
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Tremelimumab: A monoclonal antibody against CTLA-4—In combination with radiofrequency ablation (RFA) in patients with biliary tract carcinoma (BTC) by Duffy, Austin G., Pratt, Drew, Kleiner, David E, Mabry, Donna, Fioravanti, Suzanne, Walker, Melissa, Figg, William Douglas, Steinberg, Seth M., Anderson, Victoria, Levy, Elliot, Krishnasamy, Venkatesh, Wood, Bradford J., Greten, Tim F.

“…Abstract only 88 Background: Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 expressed on the surface of activated T lymphocytes and…”
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Tremelimumab: A monoclonal antibody against CTLA-4—In combination with radiofrequency ablation (RFA) in patients with biliary tract carcinoma (BTC) by Duffy, Austin G., Pratt, Drew, Kleiner, David E, Mabry, Donna, Fioravanti, Suzanne, Walker, Melissa, Figg, William Douglas, Steinberg, Seth M., Anderson, Victoria, Krishnasamy, Venkatesh, Wood, Bradford J., Greten, Tim F.

“…Abstract only 316 Background: Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 expressed on the surface of activated T lymphocytes and…”
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Hepatic artery infusion pump (HAIP) therapy in combination with targeted delivery of IL-12 for patients with metastatic colorectal cancer or intrahepatic cholangiocarcinoma: a phase II trial protocol by Victory, Jack H, Smith, Emily C, Ryan, Carrie E, Lambdin, Jacob, Sarvestani, Amber Leila, Friedman, Lindsay R, Eade, Alyssa V, Larrain, Carolina, Pu, Tracey, Luberice, Kenneth, Ramamoorthy, Bhavishya, Rainey, Ashley J, Hannah, Cathleen E, Smith, Kathleen M, Mabry, Donna, Xie, Changqing, Davis, Jeremy L, Blakely, Andrew M, Gulley, James L, Schlom, Jeffrey, Monge, Cecilia, Greten, Tim F, Hernandez, Jonathan M

“…Treatment of advanced liver tumors remains challenging. Although immune checkpoint inhibition has revolutionized treatment for many cancers, responses in…”
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Tremelimumab: A monoclonal antibody against CTLA-4—In combination with subtotal ablation (trans catheter arterial chemoembolization (TACE), radiofrequency ablation (RFA) or cryoablation) in patients with hepatocellular carcinoma (HCC) and biliary tract carcinoma (BTC) by Duffy, Austin G., Makarova-Rusher, Oxana V., Pratt, Drew, Kleiner, David E, Ulahannan, Susanna, Mabry, Donna, Fioravanti, Suzanne, Walker, Melissa, Carey, Stephanie, Figg, William Douglas, Steinberg, Seth M., Anderson, Victoria, Levy, Elliot, Krishnasamy, Venkatesh, Wood, Bradford J., Greten, Tim F.

“…Abstract only…”
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A phase I study of GPC3 targeted CAR-T cell therapy in advanced GPC3-expressing hepatocellular carcinoma (HCC) by Xie, Changqing, Monge B., M. Cecilia, Mabry-Hrones, Donna, Coffman, Kelley Lauren, Hicks, Stephanie, Redd, Bernadette, Wood, Brad, Highfill, Steven, Ho, Mitchell, Greten, Tim F.

“…TPS624 Background: The mortality of hepatocellular carcinoma (HCC) is increasing worldwide, but outcome of systemic treatments in advanced HCC is suboptimal…”
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Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma by Xie, Changqing, Duffy, Austin G, Brar, Gagandeep, Fioravanti, Suzanne, Mabry-Hrones, Donna, Walker, Melissa, Bonilla, Cecilia Monge, Wood, Bradford J, Citrin, Deborah E, Gil Ramirez, Elizabeth M, Escorcia, Freddy E, Redd, Bernadette, Hernandez, Jonathan M, Davis, Jeremy L, Gasmi, Billel, Kleiner, David, Steinberg, Seth M, Jones, Jennifer C, Greten, Tim F

“…The effectiveness of immune checkpoint inhibitors (ICI) is limited in pancreatic ductal adenocarcinoma (PDAC). We conducted a phase I study to evaluate the…”
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Long-term survival of combined ablation therapy and tremelimumab with or without durvalumab in advanced hepatocellular carcinoma by Monge B., M. Cecilia, Xie, Changqing, McVey, John, Mabry-Hrones, Donna, Duffy, Austin, Wood, Bradford J., Greten, Tim F.

“…Abstract only e16689 Background: Immune checkpoint inhibitor therapy has recently been approved for the treatment of patients with Hepatocellular Cancer (HCC)…”
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A pilot study of the combination of checkpoint inhibition with ablation in subjects with biliary tract cancer by Wetzel, Rebecca, Monge B., M. Cecilia, Xie, Changqing, Mabry-Hrones, Donna, Webb, Santhana, Akoth, Elizabeth, Redd, Bernadette, Levy, Elliot B, Wood, Bradford, Greten, Tim F.

“…Abstract only e16150 Background: Immune checkpoint inhibition has demonstrated modest activity in biliary tract carcinoma (BTC). Augmentation of the immune…”
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Phase II study of nivolumab (anti-PD1), tadalafil, and oral vancomycin in patients with refractory primary hepatocellular carcinoma or liver dominant metastatic cancer from colorectal or pancreatic cancers by Monge B., M. Cecilia, Xie, Changqing, Mabry-Hrones, Donna, Wood, Bradford J., Steinberg, Seth M., Kleiner, David E, Greten, Tim F.

“…Abstract only TPS4656 Background: Treatment options for advanced hepatocellular carcinoma (HCC) and liver dominant metastatic disease from colorectal or…”
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A phase I/II study of pexa-vec oncolytic virus in combination with immune checkpoint inhibition in refractory colorectal cancer: Safety report by Morelli, Maria Pia, Xie, Changqing, Brar, Gagan, Floudas, Charalampos S., Fioravanti, Suzanne, Walker, Melissa, Mabry-Hrones, Donna, Greten, Tim F.

“…Abstract only 646 Background: The efficacy of immune checkpoint inhibitor has been limited to small portion of colorectal cancer (CRC) patients whose tumors…”
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A phase I/II study of Pexa-Vec oncolytic virus in combination with immune checkpoint inhibition in refractory colorectal cancer by Monge B., M. Cecilia, Xie, Changqing, Steinberg, Seth M., Fioraventi, Suzanne, Walker, Melissa, Mabry-Hrones, Donna, Wood, Bradford J., Kleiner, David E, Greten, Tim F.

“…Abstract only 117 Background: The benefit of immune checkpoint inhibition is limited to the small percentage of advanced colorectal cancer (CRC) patients whose…”
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Immune checkpoint inhibition (ICI) in combination with SBRT in patients with advanced pancreatic adenocarcinoma (aPDAC) by Brar, Gagandeep, Xie, Changqing, Floudas, Charalampos S., Morelli, M. Pia, Fioravanti, Suzanne, Walker, Melissa, Mabry-Hrones, Donna, Jones, Jennifer C, Greten, Tim F.

“…Abstract only 192 Background: Chemotherapy in aPDAC has resulted in only modest improvements in outcome. The effectiveness of ICI monotherapy is also limited…”
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Perioperative MVT-5873, a fully human monoclonal antibody against a CA 19-9 epitope, for operable CA 19-9 producing pancreatic cancers, cholangiocarcinomas, and metastatic colorectal cancers by Gupta, Shreya, McDonald, James D, Ayabe, Reed I, Khan, Tahsin M, Gamble, Lauren A, Rossi, Alexander J, Sinha, Surajit, Hannah, Cathleen, Mabry-Hrones, Donna, Monge B., M. Cecilia, Blakely, Andrew M., Greten, Tim F., Davis, Jeremy L., Hernandez, Jonathan M

“…Abstract only TPS4655 Background: Operable hepatopancreatobiliary (HPB) cancers continue to pose significant challenges. Radical resections are rarely…”
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