Search Results - "Mabrouk, Omar"

Machine-Learning Algorithms to Automate Morphological and Functional Assessments in 2D Echocardiography by Narula, Sukrit, BS, Shameer, Khader, PhD, Salem Omar, Alaa Mabrouk, MD, PhD, Dudley, Joel T., PhD, Sengupta, Partho P., MD, DM

“…Abstract Background Machine-learning models may aid cardiac phenotypic recognition by using features of cardiac tissue deformation. Objectives This study…”
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Mesolimbic dopamine signals the value of work by Hamid, Arif A, Pettibone, Jeffrey R, Mabrouk, Omar S, Hetrick, Vaughn L, Schmidt, Robert, Vander Weele, Caitlin M, Kennedy, Robert T, Aragona, Brandon J, Berke, Joshua D

“…Seeking insight into dopamine's contribution to motivation and learning, the authors examined dopamine release in the rat nucleus accumbens during adaptive…”
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Enkephalin Surges in Dorsal Neostriatum as a Signal to Eat by DiFeliceantonio, Alexandra G., Mabrouk, Omar S., Kennedy, Robert T., Berridge, Kent C.

“…Compulsive overconsumption of reward characterizes disorders ranging from binge eating to drug addiction. Here, we provide evidence that enkephalin surges in…”
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Machine learning insights into scapular stabilization for alleviating shoulder pain in college students by Mabrouk, Omar M., Hady, Doaa A. Abdel, Abd El-Hafeez, Tarek

“…Non-specific shoulder pain is a common musculoskeletal condition, especially among college students, and it can have a negative impact on the patient’s life…”
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In Vivo Neurochemical Monitoring Using Benzoyl Chloride Derivatization and Liquid Chromatography–Mass Spectrometry by Song, Peng, Mabrouk, Omar S, Hershey, Neil D, Kennedy, Robert T

“…In vivo neurochemical monitoring using microdialysis sampling is important in neuroscience because it allows correlation of neurotransmission with behavior,…”
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Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples by Wong, Jenny-Marie T, Malec, Paige A, Mabrouk, Omar S, Ro, Jennifer, Dus, Monica, Kennedy, Robert T

“…•Improved reaction conditions for benzoyl chloride labeling for HPLC–MS/MS analysis.•Novel assay of 70 neurologically relevant compounds using benzoyl chloride…”
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Employing machine learning for enhanced abdominal fat prediction in cavitation post-treatment by Abdel Hady, Doaa A., Mabrouk, Omar M., Abd El-Hafeez, Tarek

“…This study investigates the application of cavitation in non-invasive abdominal fat reduction and body contouring, a topic of considerable interest in the…”
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Ultrasound imaging of core muscles activity in multiparous women with vaginal laxity: a cross-sectional study by Hady, Doaa A. Abdel, Mabrouk, Omar M., Osman, Doaa A.

“…Vaginal laxity (VL) is a common condition among multiparous women, especially those who have delivered vaginally. Since pelvic floor muscles (PFMs) work…”
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Delta Opioid Pharmacology in Parkinson's Disease by Mabrouk, Omar S

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder that compromises multiple neurochemical substrates including dopamine, norepinephrine,…”
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Right Ventricular Abnormality in Patients Hospitalized With COVID-19 Infection During Omicron Variant Surge by Salem Omar, Alaa Mabrouk, Alam, Loba, Talebi, Soheila, García-Sastre, Adolfo, Narula, Jagat, Argulian, Edgar

“…Measures of right ventricular (RV) performance during acute infection have been associated with mortality.1–3 We aimed at studying the association of…”
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Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers by Wang, Shijie, Liu, Zhiyong, Ye, Tao, Mabrouk, Omar S, Maltbie, Tyler, Aasly, Jan, West, Andrew B

“…Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase…”
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Reducing Adsorption To Improve Recovery and in Vivo Detection of Neuropeptides by Microdialysis with LC-MS by Zhou, Ying, Wong, Jenny-Marie T., Mabrouk, Omar S., Kennedy, Robert T.

“…Neuropeptides are an important class of neurochemicals; however, measuring their concentration in vivo by using microdialysis sampling is challenging due to…”
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Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity by Omer, Nurit, Giladi, Nir, Gurevich, Tanya, Bar‐Shira, Anat, Gana‐Weisz, Mali, Glinka, Tal, Goldstein, Orly, Kestenbaum, Meir, Cedarbaum, Jesse M., Mabrouk, Omar S., Fraser, Kyle B., Shirvan, Julia C., Orr‐Urtreger, Avi, Mirelman, Anat, Thaler, Avner

“…ABSTRACT Background Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are risk factors for Parkinson's disease (PD)…”
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In vivo detection of optically-evoked opioid peptide release by Al-Hasani, Ream, Wong, Jenny-Marie T, Mabrouk, Omar S, McCall, Jordan G, Schmitz, Gavin P, Porter-Stransky, Kirsten A, Aragona, Brandon J, Kennedy, Robert T, Bruchas, Michael R

“…Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to…”
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LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease by Jennings, Danna, Huntwork‐Rodriguez, Sarah, Vissers, Maurits F.J.M., Daryani, Vinay M., Diaz, Dolores, Goo, Marisa S., Chen, John J., Maciuca, Romeo, Fraser, Kyle, Mabrouk, Omar S., Wetering de Rooij, Jeroen, Heuberger, Jules A.A.C., Groeneveld, Geert Jan, Borin, Marie T., Cruz‐Herranz, Andrés, Graham, Danielle, Scearce‐Levie, Kimberly, De Vicente, Javier, Henry, Anastasia G., Chin, Peter, Ho, Carole, Troyer, Matthew D.

“…Background Leucine‐rich repeat kinase 2 (LRRK2) inhibition is a promising therapeutic approach for the treatment of Parkinson's disease (PD). Objective The aim…”
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Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery by Vander Weele, Caitlin M., Porter-Stransky, Kirsten A., Mabrouk, Omar S., Lovic, Vedran, Singer, Bryan F., Kennedy, Robert T., Aragona, Brandon J.

“…While most drugs of abuse increase dopamine neurotransmission, rapid neurochemical measurements show that different drugs evoke distinct dopamine release…”
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Ventral Tegmental Area Neurotensin Signaling Links the Lateral Hypothalamus to Locomotor Activity and Striatal Dopamine Efflux in Male Mice by Patterson, Christa M, Wong, Jenny-Marie T, Leinninger, Gina M, Allison, Margaret B, Mabrouk, Omar S, Kasper, Chelsea L, Gonzalez, Ian E, Mackenzie, Alexander, Jones, Justin C, Kennedy, Robert T, Myers, Martin G

“…Projections from the lateral hypothalamic area (LHA) innervate components of the mesolimbic dopamine (MLDA) system, including the ventral tegmental area (VTA)…”
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Microfabrication and in Vivo Performance of a Microdialysis Probe with Embedded Membrane by Lee, Woong Hee, Ngernsutivorakul, Thitaphat, Mabrouk, Omar S, Wong, Jenny-Marie T, Dugan, Colleen E, Pappas, Samuel S, Yoon, Hyeun Joong, Kennedy, Robert T

“…Microdialysis sampling is an essential tool for in vivo neurochemical monitoring. Conventional dialysis probes are over 220 μm in diameter and have limited…”
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The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease by Rideout, Hardy J., Chartier-Harlin, Marie-Christine, Fell, Matthew J., Hirst, Warren D., Huntwork-Rodriguez, Sarah, Leyns, Cheryl E. G., Mabrouk, Omar S., Taymans, Jean-Marc

“…Evidence is mounting that LRRK2 activity, particularly its kinase activity, is elevated in multiple forms of Parkinson’s disease, both idiopathic as well as…”
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Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients by Mabrouk, Omar S., Chen, Siwei, Edwards, Amanda L., Yang, Minhua, Hirst, Warren D., Graham, Danielle L.

“…Leucine-rich repeat kinase 2 (LRRK2) mutations are among the most significant genetic risk factors for developing late onset Parkinson’s disease (PD). To…”
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