Search Results - "Mabille, Dorien"

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness by Hulpia, Fabian, Mabille, Dorien, Campagnaro, Gustavo D., Schumann, Gabriela, Maes, Louis, Roditi, Isabel, Hofer, Anders, de Koning, Harry P., Caljon, Guy, Van Calenbergh, Serge

“…African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited treatment options. Trypanosoma is unable to synthesize purines de novo…”
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Impact of pulmonary African trypanosomes on the immunology and function of the lung by Mabille, Dorien, Dirkx, Laura, Thys, Sofie, Vermeersch, Marjorie, Montenye, Daniel, Govaerts, Matthias, Hendrickx, Sarah, Takac, Peter, Van Weyenbergh, Johan, Pintelon, Isabel, Delputte, Peter, Maes, Louis, Pérez-Morga, David, Timmermans, Jean-Pierre, Caljon, Guy

“…Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role of the parasite. Here we show that…”
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Comparison of Bioluminescent Substrates in Natural Infection Models of Neglected Parasitic Diseases by Hendrickx, Sarah, Bulté, Dimitri, Mabille, Dorien, Mols, Roxanne, Claes, Mathieu, Ilbeigi, Kayhan, Ahmad, Rokaya, Dirkx, Laura, Van Acker, Sara I, Caljon, Guy

“…The application of in vivo bioluminescent imaging in infectious disease research has significantly increased over the past years. The detection of transgenic…”
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Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids by Stijlemans, Benoit, De Baetselier, Patrick, Van Molle, Inge, Lecordier, Laurence, Hendrickx, Erika, Romão, Ema, Vincke, Cécile, Baetens, Wendy, Schoonooghe, Steve, Hassanzadeh-Ghassabeh, Gholamreza, Korf, Hannelie, Wallays, Marie, Pinto Torres, Joar E., Perez-Morga, David, Brys, Lea, Campetella, Oscar, Leguizamón, María S., Claes, Mathieu, Hendrickx, Sarah, Mabille, Dorien, Caljon, Guy, Remaut, Han, Roelants, Kim, Magez, Stefan, Van Ginderachter, Jo A., De Trez, Carl

“…Human African trypanosomiasis or sleeping sickness, caused by the protozoan parasite Trypanosoma brucei , is characterized by the manipulation of the host’s…”
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Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents by Setshedi, Koketso J., Beteck, Richard M., Ilbeigi, Kayhan, Mabille, Dorien, Caljon, Guy, Legoabe, Lesetja J.

“…Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and Leishmania . The corresponding…”
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Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum by Hendrickx, Sarah, Van den Kerkhof, Magali, Mabille, Dorien, Cos, Paul, Delputte, Peter, Maes, Louis, Caljon, Guy

“…Since miltefosine monotherapy against visceral leishmaniasis (VL) caused by Leishmania donovani has been discontinued in the Indian subcontinent due to an…”
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Nucleoside analogues for the treatment of animal trypanosomiasis by Mabille, Dorien, Ilbeigi, Kayhan, Hendrickx, Sarah, Ungogo, Marzuq A., Hulpia, Fabian, Lin, Cai, Maes, Louis, de Koning, Harry P., Van Calenbergh, Serge, Caljon, Guy

“…Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug…”
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Interferon Alpha Favors Macrophage Infection by Visceral Leishmania Species Through Upregulation of Sialoadhesin Expression by Van Bockstal, Lieselotte, Bulté, Dimitri, Van den Kerkhof, Magali, Dirkx, Laura, Mabille, Dorien, Hendrickx, Sarah, Delputte, Peter, Maes, Louis, Caljon, Guy

“…Type I interferons (IFNs) induced by an endogenous RNA virus or exogenous viral infections have been shown to exacerbate infections with New World Cutaneous…”
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4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei by Mabille, Dorien, Cardoso Santos, Camila, Hendrickx, Rik, Claes, Mathieu, Takac, Peter, Clayton, Christine, Hendrickx, Sarah, Hulpia, Fabian, Maes, Louis, Van Calenbergh, Serge, Caljon, Guy

“…Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to…”
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Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series by Van den Kerkhof, Magali, Leprohon, Philippe, Mabille, Dorien, Hendrickx, Sarah, Tulloch, Lindsay B, Wall, Richard J, Wyllie, Susan, Chatelain, Eric, Mowbray, Charles E, Braillard, Stéphanie, Ouellette, Marc, Maes, Louis, Caljon, Guy

“…Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. To…”
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Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening by de Heuvel, Erik, Kooistra, Albert J, Edink, Ewald, van Klaveren, Sjors, Stuijt, Jeffrey, van der Meer, Tiffany, Sadek, Payman, Mabille, Dorien, Caljon, Guy, Maes, Louis, Siderius, Marco, de Esch, Iwan J P, Sterk, Geert Jan, Leurs, Rob

“…Several members of the 3',5'-cyclic nucleotide phosphodiesterase (PDE) family play an essential role in cellular processes, which has labeled them as…”
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Inflammation following trypanosome infection and persistence in the skin by Mabille, Dorien, Caljon, Guy

“…[Display omitted] •The skin is transformed from an initial barrier to a reservoir tissue.•Skin-dwelling trypanosomes sustain transmission and complicate…”
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A breath of fresh air: impact of insect-borne protozoan parasites on the respiratory system by Araujo, Sergio, Mabille, Dorien, Garcia, Alvaro Baeza, Caljon, Guy

“…Diseases caused by insect-borne protozoan parasites, namely malaria, leishmaniasis, and trypanosomiasis, range from subclinical infections to severe illnesses…”
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Pyrazolyl amide-chalcones conjugates: Synthesis and antikinetoplastid activity by Agarwal, Devesh S, Beteck, Richard M, Mabille, Dorien, Caljon, Guy, Legoabe, Lesetja J

“…A series of novel pyrazolyl amide-chalcones conjugates was synthesized in five steps and evaluated against a range of medically important kinetoplastid…”
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C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents by Hulpia, Fabian, Bouton, Jakob, Campagnaro, Gustavo D., Alfayez, Ibrahim A., Mabille, Dorien, Maes, Louis, de Koning, Harry P., Caljon, Guy, Van Calenbergh, Serge

“…African trypanosomiasis, a deadly infectious disease caused by the protozoan Trypanosoma brucei spp., is spread to new hosts by bites of infected tsetse flies…”
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2-Aroyl quinazolinone: Synthesis and in vitro anti-parasitic activity by Setshedi, Koketso J, Beteck, Richard M, Jesumoroti, Omobolanle J, Ilbeigi, Kayhan, Mabille, Dorien, Caljon, Guy, Van der Kooy, Frank, Legoabe, Lesetja J

“…Trypanosomes and Leishmania are parasitic protozoans that affect millions of people globally. Herein we report the synthesis of 2-aroyl quinazolinones and…”
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Neutrophils enhance early Trypanosoma brucei infection onset by Caljon, Guy, Mabille, Dorien, Stijlemans, Benoît, De Trez, Carl, Mazzone, Massimiliano, Tacchini-Cottier, Fabienne, Malissen, Marie, A. Van Ginderachter, Jo, Magez, Stefan, De Baetselier, Patrick, Van Den Abbeele, Jan

“…In this study, Trypanosoma brucei was naturally transmitted to mice through the bites of infected Glossina morsitans tsetse flies. Neutrophils were recruited…”
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Evaluation of a Pan-Leishmania Spliced-Leader RNA Detection Method in Human Blood and Experimentally Infected Syrian Golden Hamsters by Eberhardt, Eline, Van den Kerkhof, Magali, Bulté, Dimitri, Mabille, Dorien, Van Bockstal, Lieselotte, Monnerat, Séverine, Alves, Fabiana, Mbui, Jane, Delputte, Peter, Cos, Paul, Hendrickx, Sarah, Maes, Louis, Caljon, Guy

“…Several methods have been developed for the detection of Leishmania, mostly targeting the minicircle kinetoplast DNA (kDNA). A new RNA real-time quantitative…”
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Structure–Activity Relationship Exploration of 3′-Deoxy-7-deazapurine Nucleoside Analogues as Anti-Trypanosoma brucei Agents by Hulpia, Fabian, Campagnaro, Gustavo D, Alzahrani, Khalid J, Alfayez, Ibrahim A, Ungogo, Marzuq A, Mabille, Dorien, Maes, Louis, de Koning, Harry P, Caljon, Guy, Van Calenbergh, Serge

“…Human African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei parasites. These protists are unable to produce the purine ring,…”
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