Search Results - "Mabhula, Amanda"
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Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity
Published in Journal of inorganic biochemistry (01-07-2017)“…A focused series of novobiocin derivatives containing a ferrocene unit together with their corresponding organic novobiocin analogues have been synthesized in…”
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Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study
Published in The Lancet infectious diseases (01-04-2016)“…Summary Background The use of injectable progestin-only contraceptives has been associated with increased risk of HIV acquisition in observational studies, but…”
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Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition
Published in PLoS pathogens (23-12-2020)“…Alterations to the mucosal environment of the female genital tract, such as genital inflammation, have been associated with increased HIV acquisition in women…”
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Plasma concentration of injectable contraceptive correlates with reduced cervicovaginal growth factor expression in South African women
Published in Mucosal immunology (01-05-2020)“…Long-acting injectable contraceptives have been associated with mucosal immune changes and increased HIV acquisition, but studies have often been hampered by…”
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Drug-resistance in Mycobacterium tuberculosis : where we stand
Published in MedChemComm (01-08-2019)“…Tuberculosis (TB), an infectious disease caused by the bacterium ( ), has burdened vulnerable populations in modern day societies for decades. Recently, this…”
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Drug-resistance in : where we stand
Published in MedChemComm (14-08-2019)“…Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium tuberculosis ( Mtb ), has burdened vulnerable populations in modern day…”
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Rv0684/fusA1, an Essential Gene, Is the Target of Fusidic Acid and Its Derivatives in Mycobacterium tuberculosis
Published in ACS infectious diseases (13-08-2021)“…Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a major global health concern given the increase in multiple forms of drug-resistant TB. This…”
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Novel 3‑Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model
Published in Journal of medicinal chemistry (22-12-2022)“…Iterative medicinal chemistry optimization of an ester-containing astemizole (AST) analogue 1 with an associated metabolic instability liability led to the…”
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Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure–Activity Relationship, Metabolism, and Biology Triaging
Published in Journal of medicinal chemistry (08-07-2021)“…Screening of a library of small polar molecules against Mycobacterium tuberculosis (Mtb) led to the identification of a potent benzoheterocyclic oxime…”
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Genital and systemic immune effects of the injectable, contraceptive norethisterone enanthate (NET‐EN), in South African women
Published in American journal of reproductive immunology (1989) (01-08-2021)“…Problem Injectable hormonal contraceptives (IHC) have been associated with altered mucosal and systemic milieu which might increase HIV risk, but most studies…”
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