Search Results - "Mabanglo, Mark F"

Reversible inhibition of the ClpP protease via an N-terminal conformational switch by Vahidi, Siavash, Ripstein, Zev A., Bonomi, Massimiliano, Yuwen, Tairan, Mabanglo, Mark F., Juravsky, Jordan B., Rizzolo, Kamran, Velyvis, Algirdas, Houry, Walid A., Vendruscolo, Michele, Rubinstein, John L., Kay, Lewis E.

“…Protein homeostasis is critically important for cell viability. Key to this process is the refolding of misfolded or aggregated proteins by molecular…”
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Substrates and interactors of the ClpP protease in the mitochondria by Mabanglo, Mark F., Bhandari, Vaibhav, Houry, Walid A.

“…The ClpP protease is found across eukaryotic and prokaryotic organisms. It is well-characterized in bacteria where its function is important in maintaining…”
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Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules by Mabanglo, Mark F., Houry, Walid A.

“…ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein homeostasis and is an important drug target in pathogenic bacteria…”
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The Streptomyces-Produced Antibiotic Fosfomycin Is a Promiscuous Substrate for Archaeal Isopentenyl Phosphate Kinase by Mabanglo, Mark F, Serohijos, Adrian W. R, Poulter, C. Dale

“…Isopentenyl phosphate kinase (IPK) catalyzes the phosphorylation of isopentenyl phosphate to form the isoprenoid precursor isopentenyl diphosphate in the…”
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X-ray Structures of Isopentenyl Phosphate Kinase by Mabanglo, Mark F, Schubert, Heidi L, Chen, Mo, Hill, Christopher P, Poulter, C. Dale

“…Isoprenoid compounds are ubiquitous in nature, participating in important biological phenomena such as signal transduction, aerobic cellular respiration,…”
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The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases by Bhandari, Vaibhav, Wong, Keith S, Zhou, Jin Lin, Mabanglo, Mark F, Batey, Robert A, Houry, Walid A

“…In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in proteostasis. The disruption of the ClpP function has been shown…”
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Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions by Yong, Darren, Ahmad, Shabbir, Mabanglo, Mark F., Halabelian, Levon, Schapira, Matthieu, Ackloo, Suzanne, Perveen, Sumera, Ghiabi, Pegah, Vedadi, Masoud

“…The DNA damage binding protein 1 (DDB1) is an essential component of protein complexes involved in DNA damage repair and the ubiquitin-proteasome system (UPS)…”
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Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR by Bigley, Andrew N, Mabanglo, Mark F, Harvey, Steven P, Raushel, Frank M

“…The V-type organophosphorus nerve agents are among the most hazardous compounds known. Previous efforts to evolve the bacterial enzyme phosphotriesterase (PTE)…”
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Structure and Reaction Mechanism of the LigJ Hydratase: An Enzyme Critical for the Bacterial Degradation of Lignin in the Protocatechuate 4,5-Cleavage Pathway by Hogancamp, Tessily N, Mabanglo, Mark F, Raushel, Frank M

“…LigJ from the soil bacterium Sphingobium sp. SYK-6 catalyzes the reversible hydration of (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to…”
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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death by Wong, Keith S, Mabanglo, Mark F, Seraphim, Thiago V, Mollica, Antonio, Mao, Yu-Qian, Rizzolo, Kamran, Leung, Elisa, Moutaoufik, Mohamed T, Hoell, Larissa, Phanse, Sadhna, Goodreid, Jordan, Barbosa, Leandro R S, Ramos, Carlos H I, Babu, Mohan, Mennella, Vito, Batey, Robert A, Schimmer, Aaron D, Houry, Walid A

“…Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved tetradecameric bacterial ClpP protease, leading to…”
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Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases by Lin, Funing, Mabanglo, Mark F, Zhou, Jin Lin, Binepal, Gursonika, Barghash, Marim M, Wong, Keith S, Gray-Owen, Scott D, Batey, Robert A, Houry, Walid A

“…A series of arylsulfones and heteroarylsulfones have previously been demonstrated to dysregulate the conserved bacterial ClpP protease, causing the unspecific…”
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Structure and Reaction Mechanism of YcjR, an Epimerase That Facilitates the Interconversion of d-Gulosides to d-Glucosides in Escherichia coli by Mabanglo, Mark F, Huddleston, Jamison P, Mukherjee, Keya, Taylor, Zane W, Raushel, Frank M

“…YcjR from K-12 MG1655 catalyzes the manganese-dependent reversible epimerization of 3-keto-α-d-gulosides to the corresponding 3-keto-α-d-glucosides as a part…”
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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome by Mabanglo, Mark F., Wong, Keith S., Barghash, Marim M., Leung, Elisa, Chuang, Stephanie H.W., Ardalan, Afshan, Majaesic, Emily M., Wong, Cassandra J., Zhang, Shen, Lang, Henk, Karanewsky, Donald S., Iwanowicz, Andrew A., Graves, Lee M., Iwanowicz, Edwin J., Gingras, Anne-Claude, Houry, Walid A.

“…The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic…”
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Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β‑Propeller Protein Fold by Mabanglo, Mark F, Xiang, Dao Feng, Bigley, Andrew N, Raushel, Frank M

“…A novel phosphotriesterase was recently discovered and purified from Sphingobium sp. TCM1 (Sb-PTE) and shown to catalyze the hydrolysis of a broad spectrum of…”
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Correction to Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β‑Propeller Protein Fold by Mabanglo, Mark F, Xiang, Dao Feng, Bigley, Andrew N, Raushel, Frank M

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Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design by Mabanglo, Mark F., Hast, Michael A., Lubock, Nathan B., Hellinga, Homme W., Beese, Lorena S.

“…Species of the fungal genus Aspergillus are significant human and agricultural pathogens that are often refractory to existing antifungal treatments. Protein…”
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Development of Antibiotics That Dysregulate the Neisserial ClpP Protease by Binepal, Gursonika, Mabanglo, Mark F, Goodreid, Jordan D, Leung, Elisa, Barghash, Marim M, Wong, Keith S, Lin, Funing, Cossette, Michele, Bansagi, Jazmin, Song, Boxi, Balasco Serrão, Vitor Hugo, Pai, Emil F, Batey, Robert A, Gray-Owen, Scott D, Houry, Walid A

“…Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing…”
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ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores by Mabanglo, Mark F., Leung, Elisa, Vahidi, Siavash, Seraphim, Thiago V., Eger, Bryan T., Bryson, Steve, Bhandari, Vaibhav, Zhou, Jin Lin, Mao, Yu-Qian, Rizzolo, Kamran, Barghash, Marim M., Goodreid, Jordan D., Phanse, Sadhna, Babu, Mohan, Barbosa, Leandro R. S., Ramos, Carlos H. I., Batey, Robert A., Kay, Lewis E., Pai, Emil F., Houry, Walid A.

“…Bacterial ClpP is a highly conserved, cylindrical, self-compartmentalizing serine protease required for maintaining cellular proteostasis. Small molecule…”
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Mutagenesis of Isopentenyl Phosphate Kinase To Enhance Geranyl Phosphate Kinase Activity by Mabanglo, Mark F, Pan, Jian-Jung, Shakya, Binita, Poulter, C. Dale

“…Isopentenyl phosphate kinase (IPK) catalyzes the ATP-dependent phosphorylation of isopentenyl phosphate (IP) to form isopentenyl diphosphate (IPP) during…”
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Potent ClpP agonists with anticancer properties bind the protease with improved structural complementarity and alter the mitochondrial N-terminome by Mabanglo, Mark F., Wong, Keith S., Barghash, Marim M., Leung, Elisa, Chuang, Stephanie H. W., Ardalan, Afshan, Majaesic, Emily M., Wong, Cassandra J., Zhang, Shen, Lang, Henk, Karanewsky, Donald S., Iwanowicz, Andrew A., Graves, Lee M., Iwanowicz, Edwin J., Gingras, Anne-Claude, Houry, Walid A.

“…The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic…”
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