Respiratory Syncytial Virus Predisposes Mice to Augmented Allergic Airway Responses Via IL-13-Mediated Mechanisms

The development of severe childhood asthma may be influenced by several factors including environmental and infectious stimuli. The causal relationship between infectious viral responses, such as respiratory syncytial virus (RSV), and severe asthma during early childhood is unclear. In these studies...

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Published in:	The Journal of immunology (1950) Vol. 167; no. 2; pp. 1060 - 1065
Main Authors:	Lukacs, Nicholas W, Tekkanat, Kim K, Berlin, Aaron, Hogaboam, Cory M, Miller, Allison, Evanoff, Holly, Lincoln, Pam, Maassab, Hussien
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 15-07-2001
Subjects:	Allergens - immunology Animals Antigens, Plant Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - prevention & control Bronchial Hyperreactivity - virology Chemokines - biosynthesis Cockroaches - immunology Cytokines - biosynthesis Immune Sera - administration & dosage Injections, Intraperitoneal Interleukin-13 - antagonists & inhibitors Interleukin-13 - immunology Interleukin-13 - physiology Lung - immunology Lung - metabolism Mice Mice, Inbred BALB C Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - prevention & control Respiratory Hypersensitivity - virology Respiratory syncytial virus Respiratory Syncytial Virus, Human - immunology
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Summary:	The development of severe childhood asthma may be influenced by several factors including environmental and infectious stimuli. The causal relationship between infectious viral responses, such as respiratory syncytial virus (RSV), and severe asthma during early childhood is unclear. In these studies, the ability for an initial RSV infection to exacerbate and promote a more severe asthmatic-type response was investigated by combining established murine models of disease. We examined the ability of RSV to induce exacerbation of allergic disease over a relatively long period, leading to development of severe airway responses including airway inflammation and hyperreactivity. The preferential production of IL-13 during a primary RSV infection appears to play a critical role for the exacerbation of cockroach allergen-induced disease. The depletion of IL-13 during RSV infections inhibited the exacerbation and acceleration of severe allergen-induced airway hyperreactivity. This was indicated by decreases in airway hyperreactivity and changes in lung chemokine production. These data suggest that the airway responses during asthma can be greatly affected by a previous RSV infection, even when infection occurs before allergen sensitization. Overall, infection of the airways with RSV can induce an IL-13-dependent change in airway function and promotes an environment that contributes to the development of severe allergic asthmatic responses.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.167.2.1060