Chromothripsis in cancer cells: An update

Chromothripsis in cancer cells: An update

In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the...

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Bibliographic Details
Published in:International journal of cancer Vol. 138; no. 10; pp. 2322 - 2333
Main Authors: Rode, Agata, Maass, Kendra Korinna, Willmund, Karolin Viktoria, Lichter, Peter, Ernst, Aurélie
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 15-05-2016
Subjects:
Animals
Cancer
Cancer therapies
Catastrophic events
catastrophic genomic rearrangement
Cell Transformation, Neoplastic - genetics
Chromosome Aberrations
Chromosomes
chromothripsis
DNA repair
Error detection
genome instability
Genomes
Genomic Instability
Genomics
Humans
Medical research
Neoplasms - genetics
Neoplasms - therapy
genome instability
catastrophic genomic rearrangement
chromothripsis
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Summary:In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous formation of multiple double‐strand breaks, which are repaired by error‐prone mechanisms. Since then, the occurrence of chromothripsis was detected in a wide range of tumor entities. In this review, we will discuss potential mechanisms of chromothripsis initiation in cancer and outline the prevalence of chromothripsis across entities. Furthermore, we will examine how chromothriptic events may promote cancer development and how they may affect cancer therapy.
Bibliography:A.R. and K.K.M. contributed equally to this work
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.29888