Search Results - "Maass, David L"

Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs by Yao, Xiao, Wigginton, Jane G, Maass, David L, Ma, Lisha, Carlson, Deborah, Wolf, Steven E, Minei, Joseph P, Zang, Qun S

“…Mitochondria-derived danger-associated molecular patterns (DAMPs) play important roles in sterile inflammation after acute injuries. This study was designed to…”
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Sepsis-induced cardiac mitochondrial dysfunction involves altered mitochondrial-localization of tyrosine kinase Src and tyrosine phosphatase SHP2 by Zang, Qun S, Martinez, Bobbie, Yao, Xiao, Maass, David L, Ma, Lisha, Wolf, Steven E, Minei, Joseph P

“…Our previous research demonstrated that sepsis produces mitochondrial dysfunction with increased mitochondrial oxidative stress in the heart. The present study…”
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Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling by Gatson, Joshua W, Maass, David L, Simpkins, James W, Idris, Ahamed H, Minei, Joseph P, Wigginton, Jane G

“…Patients with severe burn injury experience a rapid elevation in multiple circulating pro-inflammatory cytokines, with the levels correlating with both injury…”
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Cardiac mitochondrial damage and loss of ROS defense after burn injury: the beneficial effects of antioxidant therapy by Zang, Qun, Maass, David L, White, Jean, Horton, Jureta W

“…Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas Submitted 24 March 2006 ; accepted in final form 16 August 2006…”
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17β-Estradiol reappropriates mass lost to the hypermetabolic state in thermally injured rats by AbdelFattah, Kareem R., MD, Gatson, Joshua W., PhD, Maass, David L., BS, Wolf, Steven E., MD, Minei, Joseph P., MD, Wigginton, Jane G., MD

“…Abstract Background The hypermetabolic response to severe thermal injury is unlike any physiologic response seen in medicine. While some parallels can be drawn…”
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Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model by Zang, Qun S, Sadek, Hesham, Maass, David L, Martinez, Bobbie, Ma, Lisha, Kilgore, Jessica A, Williams, Noelle S, Frantz, Doug E, Wigginton, Jane G, Nwariaku, Fiemu E, Wolf, Steven E, Minei, Joseph P

“…Using a mitochondria-targeted vitamin E (Mito-Vit-E) in a rat pneumonia-related sepsis model, we examined the role of mitochondrial reactive oxygen species in…”
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Role of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsis by Zhang, Hongchao, Wang, Huan-You, Bassel-Duby, Rhonda, Maass, David L, Johnston, William E, Horton, Jureta W, Tao, Weike

“…To examine the role of myocardial interleukin-6 (IL-6) in myocardial inflammation and dysfunction after burn complicated by sepsis, we performed 40% total body…”
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Cardiac mitochondrial damage and inflammation responses in sepsis by Zang, Qun, Maass, David L, Tsai, Sue Jean, Horton, Jureta W

“…Studies in sepsis suggest that mitochondria mediate multiple organ dysfunction, including cardiac failure; however, the underlying molecular mechanisms remain…”
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IL-1β and IL-6 act synergistically with TNF-α to alter cardiac contractile function after burn trauma by MAASS, David L, WHITE, Jean, HORTON, Jureta W

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Increasing percent burn is correlated with increasing inflammation in an adult rodent model by Barber, Robert C, Maass, David L, White, D Jean, Horton, Jureta W

“…Burn injury has been associated with systemic/compartmental inflammatory responses and myocardial dysfunction. We hypothesized that burn size correlates with…”
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Burn serum causes a CD14-dependent mitochondrial damage in primary cardiomyocytes by Zang, Qun S, Maass, David L, Wigginton, Jane G, Barber, Robert C, Martinez, Bobbie, Idris, Ahamed H, Horton, Jureta W, Nwariaku, Fiemu E

“…Studies from animal models suggest that myocardial mitochondrial damage contributes to cardiac dysfunction after burn injury. In this report, we used an ex…”
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Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury by Carlson, Deborah L, Maass, David L, White, Jean, Sikes, Patricia, Horton, Jureta W

“…Departments of 1 Surgery and 2 Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas Submitted 6 November 2006 ; accepted in final form 11…”
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Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses by Carlson, Deborah, Maass, David L, White, D Jean, Tan, Jing, Horton, Jureta W

“…This study examined the effects of antioxidant vitamins on several aspects of sepsis-related myocardial signaling cascades. Sprague-Dawley rats were divided…”
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Effects of burn injury on myocardial signaling and cytokine secretion: Possible role of PKC by Tan, Jing, Maass, David L, White, D Jean, Horton, Jureta W

“…This study examined the effects of major burn injury on the cellular distribution of several PKC isoforms in adult rat hearts and examined the hypothesis that…”
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Burn injury decreases myocardial Na-K-ATPase activity: role of PKC inhibition by Horton, Jureta W, Tan, Jing, White, D Jean, Maass, David L

“…Cardiomyocyte sodium accumulation after burn injury precedes the development of myocardial contractile dysfunction. The present study examined the effects of…”
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Reducing susceptibility to bacteremia after experimental burn injury: a role for selective decontamination of the digestive tract by Horton, Jureta W, Maass, David L, White, Jean, Minei, Joseph P

“…Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas Submitted 27 October 2005 ; accepted in final form 22 January 2007 We…”
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Molecular or pharmacologic inhibition of the CD14 signaling pathway protects against burn-related myocardial inflammation and dysfunction by Barber, Robert C, Maass, David L, White, D Jean, Chang, Ling-Yu E, Horton, Jureta W

“…Signaling through toll-like receptor 4 (TLR4) plays an obligate role in burn-related myocardial dysfunction. We hypothesized that signaling through CD14, a…”
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Age-dependent differences of interleukin-6 activity in cardiac function after burn complicated by sepsis by Wang, Lin, Quan, Jiexia, Johnston, William E, Maass, David L, Horton, Jureta W, Thomas, James A, Tao, Weike

“…Abstract Interleukin (IL)-6 is a pleiotropic cytokine that is activated after acute injuries, and plays an important role during aging. We aim to define the…”
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Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma by Horton, Jureta W, White, D Jean, Maass, David L

“…Gender-related differences in immune responses to hemorrhage and sepsis have been described. However, most trauma studies continue to limit experimental models…”
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Bactericidal/permeability increasing protein attenuates the myocardial inflammation/dysfunction that occurs with burn complicated by subsequent infection by Horton, Jureta W, Maass, David L, White, D. Jean, Minei, Joseph P

“…Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas Submitted 31 May 2006 ; accepted in final form 18 June 2007 Intubation…”
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