Search Results - "Maasch, Jacqueline R M A"
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What does soil-transmitted helminth elimination look like? Results from a targeted molecular detection survey in Japan
Published in Parasites & vectors (08-01-2020)“…Japan is one of the few countries believed to have eliminated soil-transmitted helminths (STHs). In 1949, the national prevalence of Ascaris lumbricoides was…”
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Accelerating antibiotic discovery through artificial intelligence
Published in Communications biology (09-09-2021)“…By targeting invasive organisms, antibiotics insert themselves into the ancient struggle of the host-pathogen evolutionary arms race. As pathogens evolve…”
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Targeting a highly repeated germline DNA sequence for improved real-time PCR-based detection of Ascaris infection in human stool
Published in PLoS neglected tropical diseases (01-07-2019)“…With the expansion of soil transmitted helminth (STH) intervention efforts and the corresponding decline in infection prevalence, there is an increased need…”
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Comparison of multi-parallel qPCR and double-slide Kato-Katz for detection of soil-transmitted helminth infection among children in rural Bangladesh
Published in PLoS neglected tropical diseases (01-04-2020)“…There is growing interest in local elimination of soil-transmitted helminth (STH) infection in endemic settings. In such settings, highly sensitive diagnostics…”
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Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data
Published in NPJ digital medicine (09-07-2024)“…Parkinson’s disease (PD) is a serious neurodegenerative disorder marked by significant clinical and progression heterogeneity. This study aimed at addressing…”
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Molecular Dynamics for Antimicrobial Peptide Discovery
Published in Infection and immunity (17-03-2021)“…Although antimicrobial resistance is an increasingly significant public health concern, there have only been two new classes of antibiotics approved for human…”
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Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning
Published in Cell host & microbe (09-08-2023)“…Molecular de-extinction could offer avenues for drug discovery by reintroducing bioactive molecules that are no longer encoded by extant organisms. To prospect…”
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Rectal Swabs as an Alternative Sample Collection Method to Bulk Stool for the Real-Time PCR Detection of Giardia duodenalis
Published in The American journal of tropical medicine and hygiene (01-09-2020)“…Though bulk stool remains the gold standard specimen type for enteropathogen diagnosis, rectal swabs may offer comparable sensitivity with greater ease of…”
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Learning Phenotypic Associations for Parkinson's Disease with Longitudinal Clinical Records
Published in AMIA Summits on Translational Science proceedings (2024)“…Parkinson's disease (PD) is associated with multiple clinical motor and non-motor manifestations. Understanding of PD etiologies has been informed by a growing…”
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Biomedical discovery through the integrative biomedical knowledge hub (iBKH)
Published in iScience (21-04-2023)“…The abundance of biomedical knowledge gained from biological experiments and clinical practices is an invaluable resource for biomedicine. The emerging…”
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Hybrid Top-Down Global Causal Discovery with Local Search for Linear and Nonlinear Additive Noise Models
Published 23-05-2024“…Learning the unique directed acyclic graph corresponding to an unknown causal model is a challenging task. Methods based on functional causal models can…”
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Regularized Data Programming with Automated Bayesian Prior Selection
Published 16-10-2022“…The cost of manual data labeling can be a significant obstacle in supervised learning. Data programming (DP) offers a weakly supervised solution for training…”
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