Search Results - "Maas, Sybren L. N"

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis by Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Kloor, Matthias, Wefers, Annika K., Reinhardt, Annekathrin, Maas, Sybren L. N., Kratz, Christian P., Schweizer, Leonille, Hasselblatt, Martin, Snuderl, Matija, Abedalthagafi, Malak Sameer J., Abdullaev, Zied, Monoranu, Camelia M., Bergmann, Markus, Pekrun, Arnulf, Freyschlag, Christian, Aronica, Eleonora, Kramm, Christof M., Hinz, Felix, Sievers, Philipp, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M., Sturm, Dominik, Jones, David T. W., Wick, Wolfgang, Unterberg, Andreas, Hartmann, Christian, Dodgshun, Andrew, Tabori, Uri, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Reuss, David E.

“…Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair…”
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Glioblastoma hijacks microglial gene expression to support tumor growth by Maas, Sybren L N, Abels, Erik R, Van De Haar, Lieke L, Zhang, Xuan, Morsett, Liza, Sil, Srinjoy, Guedes, Joana, Sen, Pritha, Prabhakar, Shilpa, Hickman, Suzanne E, Lai, Charles P, Ting, David T, Breakefield, Xandra O, Broekman, Marike L D, El Khoury, Joseph

“…Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to…”
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Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1 by Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Maas, Sybren L. N., Sill, Martin, Dohmen, Hildegard, Banan, Rouzbeh, Reinhardt, Annekathrin, Sievers, Philipp, Hinz, Felix, Blattner-Johnson, Mirjam, Hartmann, Christian, Schweizer, Leonille, Boldt, Henning B., Kristensen, Bjarne Winther, Schittenhelm, Jens, Wood, Matthew D., Chotard, Guillaume, Bjergvig, Rolf, Das, Anirban, Tabori, Uri, Hasselblatt, Martin, Korshunov, Andrey, Abdullaev, Zied, Quezado, Martha, Aldape, Kenneth, Harter, Patrick N., Snuderl, Matija, Hench, Jürgen, Frank, Stephan, Acker, Till, Brandner, Sebastian, Winkler, Frank, Wesseling, Pieter, Pfister, Stefan M., Reuss, David E., Wick, Wolfgang, von Deimling, Andreas, Jones, David T. W., Sahm, Felix

“…Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological…”
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Multidimensional communication in the microenvirons of glioblastoma by Broekman, Marike L., Maas, Sybren L. N., Abels, Erik R., Mempel, Thorsten R., Krichevsky, Anna M., Breakefield, Xandra O.

“…Glioblastomas are heterogeneous and invariably lethal tumours. They are characterized by genetic and epigenetic variations among tumour cells, which makes the…”
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A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing by Vogel, Robert, Coumans, Frank A. W., Maltesen, Raluca G., Böing, Anita N., Bonnington, Katherine E., Broekman, Marike L., Broom, Murray F., Buzás, Edit I., Christiansen, Gunna, Hajji, Najat, Kristensen, Søren R., Kuehn, Meta J., Lund, Sigrid M., Maas, Sybren L. N., Nieuwland, Rienk, Osteikoetxea, Xabier, Schnoor, Rosalie, Scicluna, Benjamin J., Shambrook, Mitch, de Vrij, Jeroen, Mann, Stephen I., Hill, Andrew F., Pedersen, Shona

“…Understanding the pathogenic role of extracellular vesicles (EVs) in disease and their potential diagnostic and therapeutic utility is extremely reliant on…”
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Extracellular Vesicles: Unique Intercellular Delivery Vehicles by Maas, Sybren L.N, Breakefield, Xandra O, Weaver, Alissa M

“…Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers with complex cargoes including proteins, lipids, and nucleic acids…”
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Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing by de Vrij, Jeroen, Maas, Sybren L N, van Nispen, Malisa, Sena-Esteves, Miguel, Limpens, Ronald W A, Koster, Abraham J, Leenstra, Sieger, Lamfers, Martine L, Broekman, Marike L D

“…Cells secrete different types of membrane vesicles (MVs), which may act as important entities in normal human physiology and in various pathological processes…”
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Heparin in malignant glioma: review of preclinical studies and clinical results by Schnoor, Rosalie, Maas, Sybren L. N., Broekman, Marike L. D.

“…Glioblastoma multiforme (GBM) is the most common primary brain tumor that is invariably lethal. Novel treatments are desperately needed. In various cancers,…”
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Clinical implementation of integrated molecular‐morphologic risk prediction for meningioma by Hielscher, Thomas, Sill, Martin, Sievers, Philipp, Stichel, Damian, Brandner, Sebastian, Jones, David T. W., Deimling, Andreas, Sahm, Felix, Maas, Sybren L. N.

“…Risk prediction for meningioma tumors was until recently almost exclusively based on morphological features of the tumor. To improve risk prediction, multiple…”
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Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042 by Maas, Sybren L. N., Sievers, Philipp, Weber, Damien C., Weller, Michael, van den Bent, Martin J., Mair, Maximilian J., Kros, Johan M., Carparrotti, Fransesca, von Deimling, Andreas, Salvador, Villà Freixa, Peerdeman, Saskia Marguerite, Casas-Martin, Jose, Gorlia, Thierry, Sahm, Felix, Preusser, Matthias

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Comparative Analysis Identifies Similarities between the Human and Murine Microglial Sensomes by Abels, Erik R, Nieland, Lisa, Hickman, Suzanne, Broekman, Marike L D, El Khoury, Joseph, Maas, Sybren L N

“…One of the essential functions of microglia is to continuously sense changes in their environment and adapt to those changes. For this purpose, they use a set…”
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Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics by Maas, Sybren L.N., de Vrij, Jeroen, van der Vlist, Els J., Geragousian, Biaina, van Bloois, Louis, Mastrobattista, Enrico, Schiffelers, Raymond M., Wauben, Marca H.M., Broekman, Marike L.D., Nolte-'t Hoen, Esther N.M.

“…Nano-sized extracelullar vesicles (EVs) released by various cell types play important roles in a plethora of (patho)physiological processes and are…”
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Quantification and size-profiling of extracellular vesicles using tunable resistive pulse sensing by Maas, Sybren L N, De Vrij, Jeroen, Broekman, Marike L D

“…Extracellular vesicles (EVs), including 'microvesicles' and 'exosomes', are highly abundant in bodily fluids. Recent years have witnessed a tremendous increase…”
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The role of molecular biomarkers in recurrent glioblastoma trials: an assessment of the current trial landscape of genome-driven oncology by van Opijnen, Mark P., de Vos, Filip Y. F., Cuppen, Edwin, Geurts, Marjolein, Maas, Sybren L. N., Broekman, Marike L. D.

“…For glioblastoma patients, the efficacy-targeted therapy is limited to date. Most of the molecular therapies previously studied are lacking efficacy in this…”
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GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma by Abels, Erik R., Maas, Sybren L. N., Tai, Eric, Ting, David T., Broekman, Marike L. D., Breakefield, Xandra O., El Khoury, Joseph

“…Monocytes, macrophages and microglia make up a large part of the glioma environment and have an important role in maintaining and propagating glioma…”
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Investigating the Radiobiological Response to Peptide Receptor Radionuclide Therapy Using Patient-Derived Meningioma Spheroids by Reuvers, Thom G A, Grandia, Vivian, Brandt, Renata M C, Arab, Majd, Maas, Sybren L N, Bos, Eelke M, Nonnekens, Julie

“…Peptide receptor radionuclide therapy (PRRT) using Lu-DOTA-TATE has recently been evaluated for the treatment of meningioma patients. However, current…”
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Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands: interlaboratory variation in the primary diagnostic and recurrent setting by van Opijnen, Mark P., Broekman, Marike L. D., Cuppen, Edwin, Dubbink, Hendrikus J., ter Elst, Arja, van Eijk, Ronald, Mühlebner, Angelika, Jansen, Casper, van der Geize, Robert, Speel, Ernst-Jan M., Groenen, Patricia J. T. A., de Vos, Filip Y. F., Wesseling, Pieter, de Leng, Wendy W. J., Maas, Sybren L. N.

“…Purpose Next generation sequencing (NGS) is an important tool used in clinical practice to obtain the required molecular information for accurate diagnostics…”
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International practice variation in perioperative laboratory testing in glioblastoma patients—a retrospective cohort study by Senders, Joeky T., Maas, Sybren L. N., Draaisma, Kaspar, McNulty, John J., Ashby, Joanna L., Hofer, Imo, van Solinge, Wouter W., Berg, Maarten ten, Snijders, Tom J., Seute, Tatjana, Robe, Pierre A., Gormley, William B., Smith, Timothy R., Broekman, Marike L. D.

“…Purpose Although standard-of-care has been defined for the treatment of glioblastoma patients, substantial practice variation exists in the day-to-day clinical…”
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Orally Administered 5-aminolevulinic Acid for Isolation and Characterization of Circulating Tumor-Derived Extracellular Vesicles in Glioblastoma Patients by Maas, Sybren L N, van Solinge, Thomas S, Schnoor, Rosalie, Yekula, Anudeep, Senders, Joeky T, de Vrij, Jeroen, Robe, Pierre, Carter, Bob S, Balaj, Leonora, Arkesteijn, Ger J A, Nolte-'t Hoen, Esther N M, Broekman, Marike L D

“…In glioblastoma (GB), tissue is required for accurate diagnosis and subtyping. Tissue can be obtained through resection or (stereotactic) biopsy, but these…”
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Dialysis associated β2-microglobulin amyloidosis occurs even in the era of high-flux dialyzers by Falke, Lucas L., Maas, Sybren L. N., Rosati, Stefano, Logtenberg, Susan J. J.

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