Search Results - "Maaike van den Born"

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data by Grün, Dominic, Muraro, Mauro J., Boisset, Jean-Charles, Wiebrands, Kay, Lyubimova, Anna, Dharmadhikari, Gitanjali, van den Born, Maaike, van Es, Johan, Jansen, Erik, Clevers, Hans, de Koning, Eelco J.P., van Oudenaarden, Alexander

“…Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout the life of an organism. Knowing the identity of the stem cell…”
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Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas by Schepers, Arnout G., Snippert, Hugo J., Stange, Daniel E., van den Born, Maaike, van Es, Johan H., van de Wetering, Marc, Clevers, Hans

“…The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains…”
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Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon by Sasaki, Nobuo, Sachs, Norman, Wiebrands, Kay, Ellenbroek, Saskia I. J., Fumagalli, Arianna, Lyubimova, Anna, Begthel, Harry, van den Born, Maaike, van Es, Johan H., Karthaus, Wouter R., Li, Vivian S. W., López-Iglesias, Carmen, Peters, Peter J., van Rheenen, Jacco, van Oudenaarden, Alexander, Clevers, Hans

“…Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5⁺) stem cells reside at crypt bottoms of the small and large intestine. Small…”
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Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand by Boj, Sylvia F., van Es, Johan H., Huch, Meritxell, Li, Vivian S.W., José, Anabel, Hatzis, Pantelis, Mokry, Michal, Haegebarth, Andrea, van den Born, Maaike, Chambon, Pierre, Voshol, Peter, Dor, Yuval, Cuppen, Edwin, Fillat, Cristina, Clevers, Hans

“…Most studies on TCF7L2 SNP variants in the pathogenesis of type 2 diabetes (T2D) focus on a role of the encoded transcription factor TCF4 in β cells. Here, a…”
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Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters by Tetteh, Paul W., Basak, Onur, Farin, Henner F., Wiebrands, Kay, Kretzschmar, Kai, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, de Sauvage, Frederic, van Es, Johan H., van Oudenaarden, Alexander, Clevers, Hans

“…Intestinal crypts display robust regeneration upon injury. The relatively rare secretory precursors can replace lost stem cells, but it is unknown if the…”
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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids by Hu, Huili, Gehart, Helmuth, Artegiani, Benedetta, LÖpez-Iglesias, Carmen, Dekkers, Florijn, Basak, Onur, van Es, Johan, Chuva de Sousa Lopes, Susana M., Begthel, Harry, Korving, Jeroen, van den Born, Maaike, Zou, Chenhui, Quirk, Corrine, Chiriboga, Luis, Rice, Charles M., Ma, Stephanie, Rios, Anne, Peters, Peter J., de Jong, Ype P., Clevers, Hans

“…The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The “oval cell” response emanates from…”
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Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia by Koo, Bon-Kyoung, Johan H. van Es, Maaike van den Born, Hans Clevers

“…Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related transmembrane E3 ligases, encoded by Wnt target genes, that…”
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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts by Sato, Toshiro, van Es, Johan H., Snippert, Hugo J., Stange, Daniel E., Vries, Robert G., van den Born, Maaike, Barker, Nick, Shroyer, Noah F., van de Wetering, Marc, Clevers, Hans

“…Paneth cells carve out a niche Paneth cells, specialized cells found in the intestinal epithelium, are known to protect stem cells by producing bactericidal…”
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Dll1+ secretory progenitor cells revert to stem cells upon crypt damage by van Es, Johan H., Sato, Toshiro, van de Wetering, Marc, Lyubimova, Anna, Yee Nee, Annie Ng, Gregorieff, Alex, Sasaki, Nobuo, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Martens, Anton C. M., Barker, Nick, van Oudenaarden, Alexander, Clevers, Hans

“…Notch signalling in the intestinal crypt is modulated to drive commitment to the secretory fate. Clevers and colleagues find that cells expressing the Notch…”
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Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells by Snippert, Hugo J., van der Flier, Laurens G., Sato, Toshiro, van Es, Johan H., van den Born, Maaike, Kroon-Veenboer, Carla, Barker, Nick, Klein, Allon M., van Rheenen, Jacco, Simons, Benjamin D., Clevers, Hans

“…Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at the small intestinal crypt base and divide every day. We have…”
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Crypt stem cells as the cells-of-origin of intestinal cancer by van de Wetering, Marc, van Es, Johan H, Sansom, Owen J, Begthel, Harry, van den Born, Maaike, Barker, Nick, Danenberg, Esther, Clarke, Alan R, Clevers, Hans, Ridgway, Rachel A

“…Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin…”
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Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion by van Es, Johan H., Wiebrands, Kay, López-Iglesias, Carmen, van de Wetering, Marc, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Sasaki, Nobuo, Peters, Peter J., van Oudenaarden, Alexander, Clevers, Hans

“…Cycling intestinal Lgr5⁺ stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt bottoms. Paneth cells provide multiple…”
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A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal by van Es, Johan H., Haegebarth, Andrea, Kujala, Pekka, Itzkovitz, Shalev, Koo, Bon-Kyoung, Boj, Sylvia F., Korving, Jeroen, van den Born, Maaike, van Oudenaarden, Alexander, Robine, Sylvie, Clevers, Hans

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A20 controls intestinal homeostasis through cell-specific activities by Vereecke, Lars, Vieira-Silva, Sara, Billiet, Thomas, van Es, Johan H., Mc Guire, Conor, Slowicka, Karolina, Sze, Mozes, van den Born, Maaike, De Hertogh, Gert, Clevers, Hans, Raes, Jeroen, Rutgeerts, Paul, Vermeire, Severine, Beyaert, Rudi, van Loo, Geert

“…The transcription factor NF-κB is indispensable for intestinal immune homeostasis, but contributes to chronic inflammation and inflammatory bowel disease…”
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Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate by van der Flier, Laurens G., van Gijn, Marielle E., Hatzis, Pantelis, Kujala, Pekka, Haegebarth, Andrea, Stange, Daniel E., Begthel, Harry, van den Born, Maaike, Guryev, Victor, Oving, Irma, van Es, Johan H., Barker, Nick, Peters, Peter J., van de Wetering, Marc, Clevers, Hans

“…The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative cells are confined to crypts, while differentiated cell…”
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The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium by Gregorieff, Alex, Stange, Daniel E, Kujala, Pekka, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, Peters, Peter J, Clevers, Hans

“…Background & Aims Stem cells within the intestinal epithelium generate daughter cells that undergo lineage commitment and maturation through the combined…”
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SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium by Mori–Akiyama, Yuko, van den Born, Maaike, van Es, Johan H, Hamilton, Stanley R, Adams, Henry P, Zhang, Jiexin, Clevers, Hans, de Crombrugghe, Benoit

“…Background & Aims: The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell…”
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De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine by Haramis, Anna-Pavlina G., Begthel, Harry, van den Born, Maaike, van Es, Johan, Jonkheer, Suzanne, G. Johan A. Offerhaus, Clevers, Hans

“…Little is known about the signaling mechanisms that determine the highly regular patterning of the intestinal epithelium into crypts and villi. With the use of…”
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β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB by Batlle, Eduard, Henderson, Jeffrey T., Beghtel, Harry, van den Born, Maaike M.W., Sancho, Elena, Huls, Gerwin, Meeldijk, Jan, Robertson, Jennifer, van de Wetering, Marc, Pawson, Tony, Clevers, Hans

“…In the small intestine, the progeny of stem cells migrate in precise patterns. Absorptive, enteroendocrine, and goblet cells migrate toward the villus while…”
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The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis by Sylva, Marc, Li, Vivian S W, Buffing, Anita A A, van Es, Johan H, van den Born, Maaike, van der Velden, Saskia, Gunst, Quinn, Koolstra, Jan Harm, Moorman, Antoon F M, Clevers, Hans, van den Hoff, Maurice J B

“…Follistatin-like 1 (Fstl1) is a secreted protein of the BMP inhibitor class. During development, expression of Fstl1 is already found in cleavage stage embryos…”
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