Search Results - "Maagdenberg, Arn M. J. M."

Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice by Mulder, Inge A., Li, Mei, Vries, Tessa, Qin, Tao, Yanagisawa, Takeshi, Sugimoto, Kazutaka, Bogaerdt, Antoon, Danser, A. H. Jan, Wermer, Marieke J. H., Maagdenberg, Arn M. J. M., MaassenVanDenBrink, Antoinette, Ferrari, Michel D., Ayata, Cenk

“…Objective Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical…”
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Migraine and neuroinflammation: the inflammasome perspective by Kursun, Oguzhan, Yemisci, Muge, van den Maagdenberg, Arn M. J. M., Karatas, Hulya

“…Background Neuroinflammation has an important role in the pathophysiology of migraine, which is a complex neuro-glio-vascular disorder. The main aim of this…”
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Molecular genetics of migraine by de Vries, Boukje, Frants, Rune R, Ferrari, Michel D, van den Maagdenberg, Arn M. J. M

“…Migraine is an episodic neurovascular disorder that is clinically divided into two main subtypes that are based on the absence or presence of an aura: migraine…”
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Migraine pathophysiology: lessons from mouse models and human genetics by Ferrari, Michel D, Prof, Klever, Roselin R, MSc, Terwindt, Gisela M, MD, Ayata, Cenk, MD, van den Maagdenberg, Arn M J M, Prof

“…Summary Migraine is a common, disabling, and undertreated episodic brain disorder that is more common in women than in men. Unbiased genome-wide association…”
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Comprehensive Analysis of the Mouse Brain Proteome Sampled in Mass Spectrometry Imaging by Heijs, Bram, Carreira, Ricardo J, Tolner, Else A, de Ru, Arnoud H, van den Maagdenberg, Arn M. J. M, van Veelen, Peter A, McDonnell, Liam A

“…On-tissue enzymatic digestion is performed in mass spectrometry imaging (MSI) experiments to access larger proteins and to assign protein identities. Most…”
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Insights into familial adult myoclonus epilepsy pathogenesis: How the same repeat expansion in six unrelated genes may lead to cortical excitability by Depienne, Christel, Maagdenberg, Arn M. J. M., Kühnel, Theresa, Ishiura, Hiroyuki, Corbett, Mark A., Tsuji, Shoji

“…Familial adult myoclonus epilepsy (FAME) results from the same pathogenic TTTTA/TTTCA pentanucleotide repeat expansion in six distinct genes encoding proteins…”
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An organ-on-chip device with integrated charge sensors and recording microelectrodes by Aydogmus, Hande, Hu, Michel, Ivancevic, Lovro, Frimat, Jean-Philippe, van den Maagdenberg, Arn M. J. M., Sarro, Pasqualina M., Mastrangeli, Massimo

“…Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling…”
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Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice by Eikermann-Haerter, Katharina, Baum, Michael J., Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Moskowitz, Michael A., Ayata, Cenk

“…Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused by mutations in the CACNA1A gene. Mutant mice carrying the FHM1…”
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CaV2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures by Rossignol, Elsa, Kruglikov, Illya, van den Maagdenberg, Arn M. J. M., Rudy, Bernardo, Fishell, Gord

“…Objective Both the neuronal populations and mechanisms responsible for generalized spike‐wave absence seizures are poorly understood. In mutant mice carrying…”
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Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency‐dependent enhancement of visual network excitability by Perenboom, Matthijs J. L., Schenke, Maarten, Ferrari, Michel D., Terwindt, Gisela M., den Maagdenberg, Arn M. J. M., Tolner, Else A.

“…Migraine patients often report (inter)ictal hypersensitivity to light, but the underlying mechanisms remain an enigma. Both hypo‐ and hyperresponsivity of the…”
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Spinocerebellar Ataxia Type 1 Characteristics in Patient‐Derived Fibroblast and iPSC‐Derived Neuronal Cultures by Buijsen, Ronald A.M., Hu, Michel, Sáez‐González, Maria, Notopoulou, Sofia, Mina, Eleni, Koning, Winette, Gardiner, Sarah L., Graaf, Linda M., Daoutsali, Elena, Pepers, Barry A., Mei, Hailiang, Dis, Vera, Frimat, Jean‐Philippe, Maagdenberg, Arn M. J. M., Petrakis, Spyros, Roon‐Mom, Willeke M.C.

“…Background Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by a polyglutamine expansion in the ataxin‐1 protein resulting in…”
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Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine by Onderwater, Gerrit L. J., Dongen, Robin M., Harms, Amy C., Zielman, Ronald, Oosterhout, Willebrordus P. J., Klinken, Jan B., Goeman, Jelle J., Terwindt, Gisela M., Maagdenberg, Arn M. J. M., Hankemeier, Thomas, Ferrari, Michel D.

“…Objective Impaired amine metabolism has been associated with the etiology of migraine, that is, why patients continue to get migraine attacks. However,…”
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Mass spectrometry imaging of amino neurotransmitters: a comparison of derivatization methods and application in mouse brain tissue by Esteve, Clara, Tolner, Else A., Shyti, Reinald, van den Maagdenberg, Arn M. J. M., McDonnell, Liam A.

“…The detection of small polar compounds such as amino neurotransmitters by MALDI mass spectrometry imaging has been hindered by low-detection sensitivity and…”
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The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1) by Hullugundi, Swathi K, Ferrari, Michel D, van den Maagdenberg, Arn M J M, Nistri, Andrea

“…A knock-in (KI) mouse model of FHM-1 expressing the R192Q missense mutation of the Cacna1a gene coding for the α1 subunit of CaV2.1 channels shows, at the…”
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Migraine by Ferrari, Michel D., Goadsby, Peter J., Burstein, Rami, Kurth, Tobias, Ayata, Cenk, Charles, Andrew, Ashina, Messoud, van den Maagdenberg, Arn M. J. M., Dodick, David W.

“…Migraine is a common, chronic, disorder that is typically characterized by recurrent disabling attacks of headache and accompanying symptoms, including aura…”
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Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice by Dehghani, Anisa, Schenke, Maarten, van Heiningen, Sandra H., Karatas, Hulya, Tolner, Else A., van den Maagdenberg, Arn M. J. M.

“…Background Cortical spreading depolarization (CSD), the neurophysiological correlate of the migraine aura, can activate trigeminal pain pathways, but the…”
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Genetics of migraine aura: an update by de Boer, Irene, Terwindt, Gisela M., van den Maagdenberg, Arn M. J. M.

“…Migraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic…”
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Novel hypotheses emerging from GWAS in migraine? by van den Maagdenberg, Arn M. J. M., Nyholt, Dale R., Anttila, Verneri

“…Recent technical advances in genetics made large-scale genome-wide association studies (GWAS) in migraine feasible and have identified over 40 common DNA…”
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Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain by Della Pietra, Adriana, Krivoshein, Georgii, Ivanov, Konstantin, Giniatullina, Raisa, Jyrkkänen, Henna-Kaisa, Leinonen, Ville, Lehtonen, Marko, van den Maagdenberg, Arn M. J. M., Savinainen, Juha, Giniatullin, Rashid

“…Background Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading…”
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High cortical spreading depression susceptibility and migraine-associated symptoms in Cav2.1 S218L mice by van den Maagdenberg, Arn M. J. M., Pizzorusso, Tommaso, Kaja, Simon, Terpolilli, Nicole, Shapovalova, Maryna, Hoebeek, Freek E., Barrett, Curtis F., Gherardini, Lisa, van de Ven, Rob C. G., Todorov, Boyan, Broos, Ludo A. M., Tottene, Angelita, Gao, Zhenyu, Fodor, Mariann, De Zeeuw, Chris I., Frants, Rune R., Plesnila, Nikolaus, Plomp, Jaap J., Pietrobon, Daniela, Ferrari, Michel D.

“…Objective The CACNA1A gene encodes the pore‐forming subunit of neuronal CaV2.1 Ca2+ channels. In patients, the S218L CACNA1A mutation causes a dramatic…”
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