Search Results - "Maag, L."

Long noncoding RNAs in cancer: mechanisms of action and technological advancements by Bartonicek, Nenad, Maag, Jesper L V, Dinger, Marcel E

“…The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to being defined as a category of genetic elements, leaving its mark on the…”
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Benchmarking of RNA-sequencing analysis workflows using whole-transcriptome RT-qPCR expression data by Everaert, Celine, Luypaert, Manuel, Maag, Jesper L. V., Cheng, Quek Xiu, Dinger, Marcel E., Hellemans, Jan, Mestdagh, Pieter

“…RNA-sequencing has become the gold standard for whole-transcriptome gene expression quantification. Multiple algorithms have been developed to derive gene…”
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A gene–environment-induced epigenetic program initiates tumorigenesis by Alonso-Curbelo, Direna, Ho, Yu-Jui, Burdziak, Cassandra, Maag, Jesper L. V., Morris, John P., Chandwani, Rohit, Chen, Hsuan-An, Tsanov, Kaloyan M., Barriga, Francisco M., Luan, Wei, Tasdemir, Nilgun, Livshits, Geulah, Azizi, Elham, Chun, Jaeyoung, Wilkinson, John E., Mazutis, Linas, Leach, Steven D., Koche, Richard, Pe’er, Dana, Lowe, Scott W.

“…Tissue damage increases the risk of cancer through poorly understood mechanisms 1 . In mouse models of pancreatic cancer, pancreatitis associated with tissue…”
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CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity by Suan, Dan, Kräutler, Nike J., Maag, Jesper L.V., Butt, Danyal, Bourne, Katherine, Hermes, Jana R., Avery, Danielle T., Young, Clara, Statham, Aaron, Elliott, Michael, Dinger, Marcel E., Basten, Antony, Tangye, Stuart G., Brink, Robert

“…Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral…”
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Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro by Janefjord, Emelie, Mååg, Jesper L. V., Harvey, Benjamin S., Smid, Scott D.

“…Cannabinoid (CB) ligands have demonstrated neuroprotective properties. In this study we compared the effects of a diverse set of CB ligands against β…”
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SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies by Saqcena, Mahesh, Leandro-Garcia, Luis Javier, Maag, Jesper L V, Tchekmedyian, Vatche, Krishnamoorthy, Gnana P, Tamarapu, Prasanna P, Tiedje, Vera, Reuter, Vincent, Knauf, Jeffrey A, de Stanchina, Elisa, Xu, Bin, Liao, Xiao-Hui, Refetoff, Samuel, Ghossein, Ronald, Chi, Ping, Ho, Alan L, Koche, Richard P, Fagin, James A

“…Mutations of subunits of the SWI/SNF chromatin remodeling complexes occur commonly in cancers of different lineages, including advanced thyroid cancers. Here…”
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Intergenic disease-associated regions are abundant in novel transcripts by Bartonicek, N, Clark, M B, Quek, X C, Torpy, J R, Pritchard, A L, Maag, J L V, Gloss, B S, Crawford, J, Taft, R J, Hayward, N K, Montgomery, G W, Mattick, J S, Mercer, T R, Dinger, M E

“…Genotyping of large populations through genome-wide association studies (GWAS) has successfully identified many genomic variants associated with traits or…”
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Rectification in three-terminal graphene junctions by Jacobsen, A., Shorubalko, I., Maag, L., Sennhauser, U., Ensslin, K.

“…Nonlinear electrical properties of graphene-based three-terminal nanojunctions are presented. Intrinsic rectification of voltage is observed up to room…”
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Climate and chemistry effects of a regional scale nuclear conflict by Stenke, A, Hoyle, C. R, Luo, B, Rozanov, E, Gröbner, J, Maag, L, Brönnimann, S, Peter, T

“…Previous studies have highlighted the severity of detrimental effects for life on earth after an assumed regionally limited nuclear war. These effects are…”
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Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro by Harvey, Benjamin S., Ohlsson, Katharina S., Mååg, Jesper L.V., Musgrave, Ian F., Smid, Scott D.

“…► Alzheimer's protein amyloid-β and pro-oxidants elicit neurotoxicity in vitro. ► We compared neuroprotective effects of cannabinoid ligands against these…”
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Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity by Maag, Jesper L V, Panja, Debabrata, Sporild, Ida, Patil, Sudarshan, Kaczorowski, Dominik C, Bramham, Clive R, Dinger, Marcel E, Wibrand, Karin

“…Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene…”
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Novel Aberrations Uncovered in Barrett's Esophagus and Esophageal Adenocarcinoma Using Whole Transcriptome Sequencing by Maag, Jesper L V, Fisher, Oliver M, Levert-Mignon, Angelique, Kaczorowski, Dominik C, Thomas, Melissa L, Hussey, Damian J, Watson, David I, Wettstein, Antony, Bobryshev, Yuri V, Edwards, Melanie, Dinger, Marcel E, Lord, Reginald V

“…Esophageal adenocarcinoma (EAC) has one of the fastest increases in incidence of any cancer, along with poor five-year survival rates. Barrett's esophagus (BE)…”
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CD151 Gene and Protein Expression Provides Independent Prognostic Information for Patients with Adenocarcinoma of the Esophagus and Gastroesophageal Junction Treated by Esophagectomy by Fisher, Oliver M., Levert-Mignon, Angelique J., Lehane, Christopher W., Botelho, Natalia K., Maag, Jesper L. V., Thomas, Melissa L., Edwards, Melanie, Lord, Sarah J., Bobryshev, Yuri V., Whiteman, David C., Lord, Reginald V.

“…Background Esophageal and gastroesophageal junctional (GEJ) adenocarcinoma is one of the most fatal cancers and has the fastest rising incidence rate of all…”
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Uncommon Complications of Heparin-induced Thrombocytopenia by Maag, Ronald L., MD, Chuang, Cynthia H., MD, MSc

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lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs by Quek, Xiu Cheng, Thomson, Daniel W, Maag, Jesper L V, Bartonicek, Nenad, Signal, Bethany, Clark, Michael B, Gloss, Brian S, Dinger, Marcel E

“…Despite the prevalence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been examined for biological function…”
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FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer by Arruabarrena-Aristorena, Amaia, Maag, Jesper L.V., Kittane, Srushti, Cai, Yanyan, Karthaus, Wouter R., Ladewig, Erik, Park, Jane, Kannan, Srinivasaraghavan, Ferrando, Lorenzo, Cocco, Emiliano, Ho, Sik Y., Tan, Daisylyn S., Sallaku, Mirna, Wu, Fan, Acevedo, Barbara, Selenica, Pier, Ross, Dara S., Witkin, Matthew, Sawyers, Charles L., Reis-Filho, Jorge S., Verma, Chandra S., Jauch, Ralf, Koche, Richard, Baselga, José, Razavi, Pedram, Toska, Eneda, Scaltriti, Maurizio

“…Mutations in the pioneer transcription factor FOXA1 are a hallmark of estrogen receptor-positive (ER+) breast cancers. Examining FOXA1 in ∼5,000 breast cancer…”
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The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states by Barry, Guy, Briggs, James A., Hwang, Do Won, Nayler, Sam P., Fortuna, Patrick R. J., Jonkhout, Nicky, Dachet, Fabien, Maag, Jesper L. V., Mestdagh, Pieter, Singh, Erin M., Avesson, Lotta, Kaczorowski, Dominik C., Ozturk, Ezgi, Jones, Nigel C., Vetter, Irina, Arriola-Martinez, Luis, Hu, Jianfei, Franco, Gloria R., Warn, Victoria M., Gong, Andrew, Dinger, Marcel E., Rigo, Frank, Lipovich, Leonard, Morris, Margaret J., O’Brien, Terence J., Lee, Dong Soo, Loeb, Jeffrey A., Blackshaw, Seth, Mattick, John S., Wolvetang, Ernst J.

“…Despite their abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poorly understood. Here we show that the long…”
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Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo by Maag, Jesper L V, Kaczorowski, Dominik C, Panja, Debabrata, Peters, Timothy J, Bramham, Clive R, Wibrand, Karin, Dinger, Marcel E

“…DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA…”
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Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses by Yan, Juan, Chen, Yuedan, Patel, Amish J, Warda, Sarah, Lee, Cindy J, Nixon, Briana G, Wong, Elissa Wp, Miranda-Román, Miguel A, Yang, Ning, Wang, Yi, Pachai, Mohini R, Sher, Jessica, Giff, Emily, Tang, Fanying, Khurana, Ekta, Singer, Sam, Liu, Yang, Galbo, Jr, Phillip M, Maag, Jesper Lv, Koche, Richard P, Zheng, Deyou, Antonescu, Cristina R, Deng, Liang, Li, Ming O, Chen, Yu, Chi, Ping

“…Immune checkpoint blockade (ICB) has demonstrated clinical success in "inflamed" tumors with substantial T cell infiltrates, but tumors with an immune-desert…”
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PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry by Patel, Amish J, Warda, Sarah, Maag, Jesper L V, Misra, Rohan, Miranda-Román, Miguel A, Pachai, Mohini R, Lee, Cindy J, Li, Dan, Wang, Naitao, Bayshtok, Gabriella, Fishinevich, Eve, Meng, Yinuo, Wong, Elissa W P, Yan, Juan, Giff, Emily, Pappalardi, Melissa B, McCabe, Michael T, Fletcher, Jonathan A, Rudin, Charles M, Chandarlapaty, Sarat, Scandura, Joseph M, Koche, Richard P, Glass, Jacob L, Antonescu, Cristina R, Zheng, Deyou, Chen, Yu, Chi, Ping

“…Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this complex in PRC2-dependent…”
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