Search Results - "Maack, Christoph"

Calcium Signaling and Reactive Oxygen Species in Mitochondria by Bertero, Edoardo, Maack, Christoph

“…In heart failure, alterations of Na and Ca handling, energetic deficit, and oxidative stress in cardiac myocytes are important pathophysiological hallmarks…”
Get full text

Mitochondrial function in macrophages controls cardiac repair after myocardial infarction by Weissman, David, Maack, Christoph

“…Cardiac healing following acute myocardial infarction (MI) involves the mobilization and activation of immune cells, including macrophages. In the early phase…”
Get full text

Mitochondrial reactive oxygen species production and elimination by Nickel, Alexander, Kohlhaas, Michael, Maack, Christoph

“…Abstract Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one important source for ROS are mitochondria. Emission of ROS…”
Get full text

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications by Münzel, Thomas, Gori, Tommaso, Keaney, Jr, John F, Maack, Christoph, Daiber, Andreas

“…Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local…”
Get full text

Cardiac effects of SGLT2 inhibitors: the sodium hypothesis by Bertero, Edoardo, Prates Roma, Leticia, Ameri, Pietro, Maack, Christoph

“…Abstract The effects of intense glycaemic control on macrovascular complications in patients with type 2 diabetes are incompletely resolved, and many…”
Get full text

Targeted therapies for cardiac diseases by Maack, Christoph, Tardiff, Jil C.

“…Heart failure is a systemic disease in which neuroendocrine activation, inflammation and metabolic changes can impair cardiac function. In addition, variants…”
Get full text

A pathophysiological compass to personalize antianginal drug treatment by Bertero, Edoardo, Heusch, Gerd, Münzel, Thomas, Maack, Christoph

“…Myocardial ischaemia results from coronary macrovascular or microvascular dysfunction compromising the supply of oxygen and nutrients to the myocardium. The…”
Get full text

Cellular and mitochondrial mechanisms of atrial fibrillation by Mason, Fleur E., Pronto, Julius Ryan D., Alhussini, Khaled, Maack, Christoph, Voigt, Niels

“…The molecular mechanisms underlying atrial fibrillation (AF), the most common form of arrhythmia, are poorly understood and therefore target-specific treatment…”
Get full text

Mitochondria as Therapeutic Targets in Heart Failure by Schwemmlein, Julia, Maack, Christoph, Bertero, Edoardo

“…Purpose of Review We review therapeutic approaches aimed at restoring function of the failing heart by targeting mitochondrial reactive oxygen species (ROS),…”
Get full text

Adverse Bioenergetic Consequences of Na+-Ca2+ Exchanger-Mediated Ca2+ Influx in Cardiac Myocytes by KOHLHAAS, Michael, MAACK, Christoph

“…In heart failure, the Na+-Ca²+ exchanger (NCX) is upregulated and mediates Ca²+ influx (instead of efflux) during the cardiac action potential. Although this…”
Get full text

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology by Maack, Christoph, Lehrke, Michael, Backs, Johannes, Heinzel, Frank R, Hulot, Jean-Sebastien, Marx, Nikolaus, Paulus, Walter J, Rossignol, Patrick, Taegtmeyer, Heinrich, Bauersachs, Johann, Bayes-Genis, Antoni, Brutsaert, Dirk, Bugger, Heiko, Clarke, Kieran, Cosentino, Francesco, De Keulenaer, Gilles, Dei Cas, Alessandra, González, Arantxa, Huelsmann, Martin, Iaccarino, Guido, Lunde, Ida Gjervold, Lyon, Alexander R, Pollesello, Piero, Rena, Graham, Riksen, Niels P, Rosano, Giuseppe, Staels, Bart, van Laake, Linda W, Wanner, Christoph, Farmakis, Dimitrios, Filippatos, Gerasimos, Ruschitzka, Frank, Seferovic, Petar, de Boer, Rudolf A, Heymans, Stephane

Get full text

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology by de Boer, Rudolf A., De Keulenaer, Gilles, Bauersachs, Johann, Brutsaert, Dirk, Cleland, John G., Diez, Javier, Du, Xiao‐Jun, Ford, Paul, Heinzel, Frank R., Lipson, Kenneth E., McDonagh, Theresa, Lopez‐Andres, Natalia, Lunde, Ida G., Lyon, Alexander R., Pollesello, Piero, Prasad, Sanjay K., Tocchetti, Carlo G., Mayr, Manuel, Sluijter, Joost P.G., Thum, Thomas, Tschöpe, Carsten, Zannad, Faiez, Zimmermann, Wolfram‐Hubertus, Ruschitzka, Frank, Filippatos, Gerasimos, Lindsey, Merry L., Maack, Christoph, Heymans, Stephane

“…Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and…”
Get full text

The continuous heart failure spectrum: moving beyond an ejection fraction classification by Triposkiadis, Filippos, Butler, Javed, Abboud, Francois M, Armstrong, Paul W, Adamopoulos, Stamatis, Atherton, John J, Backs, Johannes, Bauersachs, Johann, Burkhoff, Daniel, Bonow, Robert O, Chopra, Vijay K, de Boer, Rudolf A, de Windt, Leon, Hamdani, Nazha, Hasenfuss, Gerd, Heymans, Stephane, Hulot, Jean-Sébastien, Konstam, Marvin, Lee, Richard T, Linke, Wolfgang A, Lunde, Ida G, Lyon, Alexander R, Maack, Christoph, Mann, Douglas L, Mebazaa, Alexandre, Mentz, Robert J, Nihoyannopoulos, Petros, Papp, Zoltan, Parissis, John, Pedrazzini, Thierry, Rosano, Giuseppe, Rouleau, Jean, Seferovic, Petar M, Shah, Ajay M, Starling, Randall C, Tocchetti, Carlo G, Trochu, Jean-Noel, Thum, Thomas, Zannad, Faiez, Brutsaert, Dirk L, Segers, Vincent F, De Keulenaer, Gilles W

“…Abstract Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations…”
Get full text

Elevated Cytosolic Na+ Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes by KOHLHAAS, Michael, TING LIU, KNOPP, Andreas, ZELLER, Tanja, MEI FANG ONG, BÖHM, Michael, O'ROURKE, Brian, MAACK, Christoph

“…Oxidative stress is causally linked to the progression of heart failure, and mitochondria are critical sources of reactive oxygen species in failing…”
Get full text

Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future by Wintrich, Jan, Kindermann, Ingrid, Ukena, Christian, Selejan, Simina, Werner, Christian, Maack, Christoph, Laufs, Ulrich, Tschöpe, Carsten, Anker, Stefan D., Lam, Carolyn S. P., Voors, Adriaan A., Böhm, Michael

“…In contrast to the wealth of proven therapies for heart failure with reduced ejection fraction (HFrEF), therapeutic efforts in the past have failed to improve…”
Get full text

Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) by Boer, Rudolf A., Hulot, Jean‐Sébastien, Tocchetti, Carlo Gabriele, Aboumsallem, Joseph Pierre, Ameri, Pietro, Anker, Stefan D., Bauersachs, Johann, Bertero, Edoardo, Coats, Andrew J.S., Čelutkienė, Jelena, Chioncel, Ovidiu, Dodion, Pierre, Eschenhagen, Thomas, Farmakis, Dimitrios, Bayes‐Genis, Antoni, Jäger, Dirk, Jankowska, Ewa A., Kitsis, Richard N., Konety, Suma H., Larkin, James, Lehmann, Lorenz, Lenihan, Daniel J., Maack, Christoph, Moslehi, Javid J., Müller, Oliver J., Nowak‐Sliwinska, Patrycja, Piepoli, Massimo Francesco, Ponikowski, Piotr, Pudil, Radek, Rainer, Peter P., Ruschitzka, Frank, Sawyer, Douglas, Seferovic, Petar M., Suter, Thomas, Thum, Thomas, Meer, Peter, Van Laake, Linda W., Haehling, Stephan, Heymans, Stephane, Lyon, Alexander R., Backs, Johannes

“…The co‐occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In…”
Get full text

Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart by Wagner, Michael, Bertero, Edoardo, Nickel, Alexander, Kohlhaas, Michael, Gibson, Gary E., Heggermont, Ward, Heymans, Stephane, Maack, Christoph

“…In heart failure, a functional block of complex I of the respiratory chain provokes superoxide generation, which is transformed to H 2 O 2 by dismutation. The…”
Get full text

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure by Nickel, Alexander G., von Hardenberg, Albrecht, Hohl, Mathias, Löffler, Joachim R., Kohlhaas, Michael, Becker, Janne, Reil, Jan-Christian, Kazakov, Andrey, Bonnekoh, Julia, Stadelmaier, Moritz, Puhl, Sarah-Lena, Wagner, Michael, Bogeski, Ivan, Cortassa, Sonia, Kappl, Reinhard, Pasieka, Bastian, Lafontaine, Michael, Lancaster, C. Roy D., Blacker, Thomas S., Hall, Andrew R., Duchen, Michael R., Kästner, Lars, Lipp, Peter, Zeller, Tanja, Müller, Christian, Knopp, Andreas, Laufs, Ulrich, Böhm, Michael, Hoth, Markus, Maack, Christoph

“…Mitochondrial reactive oxygen species (ROS) play a central role in most aging-related diseases. ROS are produced at the respiratory chain that demands NADH for…”
Get full text

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca2+ Crosstalk by Chen, Yun, Csordás, György, Jowdy, Casey, Schneider, Timothy G, Csordás, Norbert, Wang, Wei, Liu, Yingqiu, Kohlhaas, Michael, Meiser, Maxie, Bergem, Stefanie, Nerbonne, Jeanne M, Dorn, Gerald W, Maack, Christoph

“…RATIONALE:Mitochondrial Ca uptake is essential for the bioenergetic feedback response through stimulation of Krebs cycle dehydrogenases. Close association of…”
Get full text

Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling by Puhl, Sarah-Lena, Hilby, Michael, Kohlhaas, Michael, Keidel, Linus M., Jansen, Yvonne, Hristov, Michael, Schindler, Jakob, Maack, Christoph, Steffens, Sabine

“…While classical cannabinoid receptors are known to crucially impact on myocardial infarction (MI) repair, a function of the cannabinoid-sensitive receptor…”
Get full text