Search Results - "Ma. Xenia G. Ilagan"

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2 by Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Liu, Zhuoming, Zhao, Haiyan, Kim, Arthur S., Bloyet, Louis-Marie, Zeng, Qiru, Tahan, Stephen, Droit, Lindsay, Ilagan, Ma. Xenia G., Tartell, Michael A., Amarasinghe, Gaya, Henderson, Jeffrey P., Miersch, Shane, Ustav, Mart, Sidhu, Sachdev, Virgin, Herbert W., Wang, David, Ding, Siyuan, Corti, Davide, Theel, Elitza S., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.

“…Antibody-based interventions against SARS-CoV-2 could limit morbidity, mortality, and possibly transmission. An anticipated correlate of such countermeasures…”
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γ-Secretase: proteasome of the membrane? by Kopan, Raphael, Ilagan, Ma. Xenia G

“…gamma -Secretase, a protease that cleaves within the membrane, was first recognized for its role in the production of amyloidogenic A beta peptides, but was…”
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The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development by Liu, Zhenyi, Chen, Shuang, Boyle, Scott, Zhu, Yu, Zhang, Andrew, Piwnica-Worms, David R., Ilagan, Ma. Xenia G., Kopan, Raphael

“…Notch2, but not Notch1, plays indispensable roles in kidney organogenesis, and Notch2 haploinsufficiency is associated with Alagille syndrome. We proposed that…”
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Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model by Salvatore, Sofia V., Ilagan, Ma. Xenia G., Shu, Hongjin, Lambert, Peter M., Benz, Ann, Qian, Mingxing, Covey, Douglas F., Zorumski, Charles F., Mennerick, Steven

“…Neuropsychiatric and neurodegenerative disorders are correlated with cellular stress. Macroautophagy (autophagy) may represent an important protective pathway…”
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A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants by Pishesha, Novalia, Harmand, Thibault J., Rothlauf, Paul W., Praest, Patrique, Alexander, Ryan K., van den Doel, Renate, Liebeskind, Mariel J., Vakaki, Maria A., McCaul, Nicholas, Wijne, Charlotte, Verhaar, Elisha, Pinney, William, Heston, Hailey, Bloyet, Louis-Marie, Pontelli, Marjorie Cornejo, Ilagan, Ma. Xenia G., Lebbink, Robert Jan, Buchser, William J., Wiertz, Emmanuel J. H. J., Whelan, Sean P. J., Ploegh, Hidde L.

“…The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 100 million infections and millions of deaths…”
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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism by Kopan, Raphael, Ilagan, Ma. Xenia G.

“…Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide…”
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An overview of notch signaling in adult tissue renewal and maintenance by Sato, Chihiro, Zhao, Guojun, Ilagan, Ma Xenia G

“…The Notch pathway is a critical mediator of short-range cell-cell communication that is reiteratively used to regulate a diverse array of cellular processes…”
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RNF4-Dependent Oncogene Activation by Protein Stabilization by Thomas, Jane J., Abed, Mona, Heuberger, Julian, Novak, Rostislav, Zohar, Yaniv, Beltran Lopez, Angela P., Trausch-Azar, Julie S., Ilagan, Ma. Xenia G., Benhamou, David, Dittmar, Gunnar, Kopan, Raphael, Birchmeier, Walter, Schwartz, Alan L., Orian, Amir

“…Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that…”
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The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans by Maybruck, Brian T, Lam, Woei C, Specht, Charles A, Ilagan, Ma Xenia G, Donlin, Maureen J, Lodge, Jennifer K

“…can cause fatal meningoencephalitis in patients with AIDS or other immunocompromising conditions. Current antifungals are suboptimal to treat this disease;…”
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Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands by Chillakuri, Chandramouli R., Sheppard, Devon, Ilagan, Ma. Xenia G., Holt, Laurie R., Abbott, Felicity, Liang, Shaoyan, Kopan, Raphael, Handford, Penny A., Lea, Susan M.

“…The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system…”
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Analysis of Notch Function in Presomitic Mesoderm Suggests a γ-Secretase-Independent Role for Presenilins in Somite Differentiation by Huppert, Stacey S., Ilagan, Ma. Xenia G., De Strooper, Bart, Kopan, Raphael

“…The role of Notch signaling in general and presenilin in particular was analyzed during mouse somitogenesis. We visualize cyclical production of activated…”
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A Presenilin Dimer at the Core of the γ-Secretase Enzyme: Insights from Parallel Analysis of Notch 1 and APP Proteolysis by Schroeter, Eric H., Ma. Xenia G. Ilagan, Brunkan, Anne L., Hecimovic, Silva, Li, Yue-ming, Xu, Min, Lewis, Huw D., Saxena, Meera T., De Strooper, Bart, Coonrod, Archie, Tomita, Taisuke, Iwatsubo, Takeshi, Moore, Chad L., Goate, Alison, Wolfe, Michael S., Shearman, Mark, Kopan, Raphael

“…Notch receptors and the amyloid precursor protein are type I membrane proteins that are proteolytically cleaved within their transmembrane domains by a…”
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Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor by Yang, Katherine S., Ilagan, Ma.Xenia G., Piwnica-Worms, David, Pike, Linda J.

“…Crystal structures of the epidermal growth factor (EGF) receptor suggest that its activation is associated with extensive conformational changes in both the…”
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A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35–NP Interface by Liu, Gai, Nash, Peter J, Johnson, Britney, Pietzsch, Colette, Ilagan, Ma. Xenia G, Bukreyev, Alexander, Basler, Christopher F, Bowlin, Terry L, Moir, Donald T, Leung, Daisy W, Amarasinghe, Gaya K

“…The 2014 Ebola outbreak in West Africa, the largest outbreak on record, highlighted the need for novel approaches to therapeutics targeting Ebola virus (EBOV)…”
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Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice by Hodges, Wesley T., Jarasvaraparn, Chaowapong, Ferguson, Daniel, Griffett, Kristine, Gill, Lauren E., Chen, Yana, Ilagan, Ma. Xenia G., Hegazy, Lamees, Elgendy, Bahaa, Cho, Kevin, Patti, Gary J., McCommis, Kyle S., Finck, Brian N.

“…The mitochondrial pyruvate carrier (MPC) is an inner mitochondrial membrane complex that plays a critical role in intermediary metabolism. Inhibition of the…”
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Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin by Zhao, Guojun, Liu, Zhenyi, Ilagan, Ma Xenia G, Kopan, Raphael

“…Gamma-secretase is a multiprotein, intramembrane-cleaving protease with a growing list of protein substrates, including the Notch receptors and the amyloid…”
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Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes by Kopan, Raphael, McArthur, Debbie G, Hass, Matthew, Aster, Jon C, Blacklow, Stephen C, Ilagan, Ma Xenia G, Arnett, Kelly L

“…Notch signaling regulates key developmental events, and aberrant Notch signaling has been linked to disease. The structure of a dimeric Notch transcription…”
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Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch? by Ilagan, Ma. Xenia G., Kopan, Raphael

“…NOTCH1, which is frequently mutated in T cell acute lymphoblastic leukemia, has been an elusive therapeutic target. In this issue of Cancer Cell, Roti and…”
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Real-time imaging of notch activation with a luciferase complementation-based reporter by Ilagan, Ma Xenia G, Lim, Sora, Fulbright, Mary, Piwnica-Worms, David, Kopan, Raphael

“…Notch signaling regulates many cellular processes during development and adult tissue renewal. Upon ligand binding, Notch receptors undergo ectodomain shedding…”
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Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering by Heitmeier, Monique R, Hresko, Richard C, Edwards, Rachel L, Prinsen, Michael J, Ilagan, Ma Xenia G, Odom John, Audrey R, Hruz, Paul W

“…Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule…”
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