Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study

The aim of the study was to evaluate the variant (rs2910829) of the PDE4D gene in relation to its influence on biochemical, anthropometric and physiological parameters in patients with coronary artery disease and healthy subjects of the Eastern Slovak population. The male group consisted of 72 indiv...

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Published in:	Central European journal of public health Vol. 31; no. Suppl 1; pp. S75 - S81
Main Authors:	Mydlárová Blaščáková, Marta, Hricová, Katarína, Mašlejová, Katarína, Majherová, Mária, Vašková, Hedviga, Poráčová, Janka, Bernátová, Renáta, Konečná, Mária, Sedlák, Vincent
Format:	Journal Article
Language:	English
Published:	Czech Republic National Institute of Public Health 01-12-2023
Subjects:	Alleles Anthropometry Atherosclerosis Biochemical markers Biochemistry Blood pressure Body height Body mass index Cardiovascular disease Cardiovascular diseases Coronary artery disease Coronary vessels Disease control Gene polymorphism Genetic analysis Genotype & phenotype Genotypes Health care Heart Heart diseases High density lipoprotein Ischemia Lipids Low density lipoprotein Men Mortality Parameters Peripheral blood Phosphodiesterase Physiology Pilot projects Polymorphism Population Population genetics Statistical analysis Vein & artery diseases Women Womens health Slovakia Hungary United States > US Germany cardiovascular disease lipids diastolic systolic PDE4D gene BMI
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Summary:	The aim of the study was to evaluate the variant (rs2910829) of the PDE4D gene in relation to its influence on biochemical, anthropometric and physiological parameters in patients with coronary artery disease and healthy subjects of the Eastern Slovak population. The male group consisted of 72 individuals and the female group consisted of 132 individuals. On the basis of clinical screening the subjects were divided into two groups - with ischaemic heart disease and control group. Genomic DNA was isolated from peripheral blood using a commercial NucleoSpin Blood Machenery-Nagel kit. Molecular genetic analysis of the polymorphism under study was performed using the StepOne™ Real-Time PCR System instrument. The lipid profile markers TC, HDL, LDL, TG were measured by Cobas Integra 400 plus biochemical analyser, and systolic and diastolic blood pressure using a digital blood pressure monitor. Among anthropometric parameters, body height and weight, waist and hip circumference were measured and BMI and WHR indices were calculated. A statistically significant (p = 0.018) possible association between the mutant T allele and ischaemic heart disease was found in men. In women, we found a statistically significant difference in the systolic (p = 0.013) and diastolic blood parameters (p = 0.005) in the CC genotype. In the group of women, we found statistically significant differences in all observed anthropometric parameters and in LDL and TC markers. In the group of men divided on the basis of BMI, statistical significance was found in systolic blood pressure (p = 0.028). In the group of women with ischaemic heart disease, we found a negative correlation between BMI and HDL. The study contributes to new findings of the representation of genotypes and alleles of the rs2910829 PDE4D gene polymorphism in the Slovak population. This is a pilot study. Interactions between genotype and observed anthropometric, physiological and biochemical markers were confirmed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1210-7778 1803-1048
DOI:	10.21101/cejph.a7843