Search Results - "Mačiulaitis, Romaldas"

Risk of tumorigenicity in mesenchymal stromal cell–based therapies—Bridging scientific observations and regulatory viewpoints by Barkholt, Lisbeth, Flory, Egbert, Jekerle, Veronika, Lucas-Samuel, Sophie, Ahnert, Peter, Bisset, Louise, Büscher, Dirk, Fibbe, Willem, Foussat, Arnaud, Kwa, Marcel, Lantz, Olivier, Mačiulaitis, Romaldas, Palomäki, Tiina, Schneider, Christian K, Sensebé, Luc, Tachdjian, Gérard, Tarte, Karin, Tosca, Lucie, Salmikangas, Paula

“…Abstract In the past decade, the therapeutic value of mesenchymal stromal cells (MSCs) has been studied in various indications, thereby taking advantage of…”
Get full text

Preclinical study of SZ2080 material 3D microstructured scaffolds for cartilage tissue engineering made by femtosecond direct laser writing lithography by Mačiulaitis, Justinas, Deveikytė, Milda, Rekštytė, Sima, Bratchikov, Maksim, Darinskas, Adas, Šimbelytė, Agnė, Daunoras, Gintaras, Laurinavičienė, Aida, Laurinavičius, Arvydas, Gudas, Rimtautas, Malinauskas, Mangirdas, Mačiulaitis, Romaldas

“…Over the last decade DLW employing ultrafast pulsed lasers has become a well-established technique for the creation of custom-made free-form three-dimensional…”
Get more information

Characterization of tissue engineered cartilage products: Recent developments in advanced therapy by Mačiulaitis, Justinas, Rekštytė, Sima, Ūsas, Arvydas, Jankauskaitė, Virginija, Gudas, Rimtautas, Malinauskas, Mangirdas, Mačiulaitis, Romaldas

“…[Display omitted] Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This…”
Get full text

Human Placental Mesenchymal Stem Cells and Derived Extracellular Vesicles Ameliorate Lung Injury in Acute Respiratory Distress Syndrome Murine Model by Valiukevičius, Paulius, Mačiulaitis, Justinas, Pangonytė, Dalia, Siratavičiūtė, Vitalija, Kluszczyńska, Katarzyna, Kuzaitytė, Ugnė, Insodaitė, Rūta, Čiapienė, Ieva, Grigalevičiūtė, Ramunė, Zigmantaitė, Vilma, Vitkauskienė, Astra, Mačiulaitis, Romaldas

“…This study investigates the therapeutic potential of human placental mesenchymal stem cells (P-MSCs) and their extracellular vesicles (EVs) in a murine model…”
Get full text

Challenges with advanced therapy medicinal products and how to meet them by Schneider, Christian K, Salmikangas, Paula, Jilma, Bernd, Flamion, Bruno, Todorova, Lyubina Racheva, Paphitou, Anna, Haunerova, Ivana, Maimets, Toivo, Trouvin, Jean-Hugues, Flory, Egbert, Tsiftsoglou, Asterios, Sarkadi, Balázs, Gudmundsson, Kolbeinn, O'Donovan, Maura, Migliaccio, Giovanni, Ancāns, Jānis, Maciulaitis, Romaldas, Robert, Jean-Louis, Samuel, Anthony, Ovelgönne, Johannes H, Hystad, Marit, Fal, Andrzej Mariusz, Lima, Beatriz Silva, Moraru, Anca Stela, Turcáni, Peter, Zorec, Robert, Ruiz, Sol, Akerblom, Lennart, Narayanan, Gopalan, Kent, Alastair, Bignami, Fabrizia, Dickson, J George, Niederwieser, Dietger, Figuerola-Santos, María-Angeles, Reischl, Ilona G, Beuneu, Claire, Georgiev, Rosen, Vassiliou, Maria, Pychova, Alena, Clausen, Mette, Methuen, Taina, Lucas, Sophie, Schüssler-Lenz, Martina, Kokkas, Vasilios, Buzás, Zsuzsanna, MacAleenan, Niall, Galli, Maria Cristina, Linē, Aija, Gulbinovic, Jolanta, Berchem, Guy, Fraczek, Mariusz, Menezes-Ferreira, Margarida, Vilceanu, Nela, Hrubisko, Mikulás, Marinko, Petra, Timón, Marcos, Cheng, Wing, Crosbie, George Andrew, Meade, Nick, di Paola, Michelino Lipucci, VandenDriessche, Thierry, Ljungman, Per, D'Apote, Lucia, Oliver-Diaz, Olga, Büttel, Isabel, Celis, Patrick

“…Advanced therapy medicinal products (ATMPs) offer hope for the treatment of diseases for which therapeutic options are currently lacking. This article…”
Get full text

Cell and Gene Therapies: European View on Challenges in Translation and How to Address Them by Rousseau, Cécile F, Mačiulaitis, Romaldas, Śladowski, Dariusz, Narayanan, Gopalan

“…Advanced therapy medicinal products (ATMPs), ., cell and gene therapy products, is a rapidly evolving field of therapeutic development. A significant…”
Get full text

Appropriate antibiotic prescribing among final-year medical students in Europe by van der Voort, Tim, Brinkman, David J., Benemei, Silvia, Böttiger, Ylva, Chamontin, Bernard, Christiaens, Thierry, Likic, Robert, Mačiulaitis, Romaldas, Marandi, Toomas, Monteiro, Emilia C., Papaioannidou, Paraskevi, Pers, Yves M., Pontes, Caridad, Raskovic, Aleksandar, Regenthal, Ralf, Sanz, Emilio J., Wilson, Kurt, Tichelaar, Jelle, van Agtmael, Michiel A.

“…•European medical students have poor antimicrobial pharmacotherapeutic skills.•Student prescriptions are highly heterogeneous and often contain errors. Little…”
Get full text

Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics by Bakkum, Michiel J., Tichelaar, Jelle, Papaioannidou, Paraskevi, Likic, Robert, Sanz Alvarez, Emilio J., Christiaens, Thierry, Costa, João N., Mačiulaitis, Romaldas, Dima, Lorena, Coleman, Jamie, Richir, Milan C., Agtmael, Michiel A., Atanasova, Ivanka, Ganeva, Maria, Gatchev, Emil, Kostadinova, I. I., Mimica Matanovic, S., Vitezic, D, Greta, Wozniak, Kmonickova, E., Karel, Urbanek, Damkier, P., Huupponen, R. K., Auffret, Marine, Bejan‐Angoulvant, T., Laurent, Chouchana, Jean‐Luc, Cracowski, Drici, M. D., Faillie, J. L., Hélène, Geniaux, Molimard, M., Orlikowski, D., Palin, Karine, Pers, Y.‐M., Picard, Nicolas, Simon, N., Toussirot, E., Boger, R. H., Cascorbi, I., Mueller, S. C., Regenthal, R., Schwab, M., Schwaninger, M. S., Thuermann, P. A., Wojnowski, L., Kouvelas, D., Riba, P., Kerins, David M., Williams, David J., Cosentino, M., De Ponti, Fabrizio, Filippelli, Amelia, Leone, R., Locatelli, Vittorio, Jansone, Baiba, Gulbinovic, Romaldas, Mifsud, Janet, Braszko Jan, J., Kocic, I., Luiza, Breitenfeld, Castelo‐Branco, M., Simona, Conea, Ioan, Magyar, Bevc, S., Mojca, Krzan, Bernal, M. L., Capellà, D., Carcas, A., De Abajo, F. J., Lopez‐Rico, M., Lucena, M. I., Pontes, C., Sanz, E. J., Böttiger, Y., Le Grevès, Madeleine, Waard‐Siebinga, I., Janssen Ben, J. A., Wilma, Knol, Rahul, Pandit, Rosse, F., Dent, G., Albert, Ferro, Hitchings, A. W., Kapil, V., Linton, K. D., Loke, Y. K., Michael, Okorie, David, Plumb Richard, Pontefract, Sarah, Ranmuthu, S., Sampson, A. P., Thanacoody, H. K. R., Whitfield Jonathan, P., Wilson, Kurt

“…Aim Improvement and harmonization of European clinical pharmacology and therapeutics (CPT) education is urgently required. Because digital educational…”
Get full text

Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease by Liabeuf, Sophie, Hafez, Gaye, Pešić, Vesna, Spasovski, Goce, Bobot, Mickaël, Mačiulaitis, Romaldas, Bumblyte, Inga Arune, Ferreira, Ana Carina, Farinha, Ana, Malyszko, Jolanta, Pépin, Marion, Massy, Ziad A, Unwin, Robert, Capasso, Giovambattista, Mani, Laila-Yasmin

“…The relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs)…”
Get full text

Skeletal muscle-derived stem cells: implications for cell-mediated therapies by Usas, Arvydas, Mačiulaitis, Justinas, Mačiulaitis, Romaldas, Jakubonienė, Neli, Milašius, Arvydas, Huard, Johnny

“…Current advances in stem cell research and innovative biological approaches in the field of tissue engineering and regenerative medicine could eventually…”
Get full text

Muscle-Derived Stem/Progenitor Cells Ameliorate Acute Kidney Injury in Rats through the Anti-Apoptotic Pathway and Demonstrate Comparable Effects to Bone Marrow Mesenchymal Stem Cells by Pavyde, Egle, Usas, Arvydas, Pockevicius, Alius, Maciulaitis, Romaldas

“…: To date, the therapeutic potential of skeletal muscle-derived stem/progenitor cells (MDSPCs) for acute kidney injury (AKI) has only been evaluated by our…”
Get full text

Change in Albuminuria and Estimated GFR as End Points for Clinical Trials in Early Stages of CKD: A Perspective From European Regulators by Holtkamp, Frank, Gudmundsdottir, Hrefna, Maciulaitis, Romaldas, Benda, Norbert, Thomson, Andrew, Vetter, Thorsten

Get full text

Prevention of Transition from Acute Kidney Injury to Chronic Kidney Disease Using Clinical-Grade Perinatal Stem Cells in Non-Clinical Study by Gryguc, Agne, Maciulaitis, Justinas, Mickevicius, Lukas, Laurinavicius, Arvydas, Sutkeviciene, Neringa, Grigaleviciute, Ramune, Zigmantaite, Vilma, Maciulaitis, Romaldas, Bumblyte, Inga Arune

“…Acute kidney injury (AKI) is widely recognized as a precursor to the onset or rapid progression of chronic kidney disease (CKD). However, there is currently no…”
Get full text

Rationality of administered gentamicin dose in cerebral coma patients treated in an intensive care unit by Janušonis, Tomas, Mačiulaitis, Romaldas, Sveikata, Audrius, Milašius, Arvydas, Kregždytė, Rima

“…Gentamicin is still widely used in the treatment of patients in an intensive care unit (ICU). The efficacy of aminoglycosides correlates with the peak serum…”
Get full text

Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium by Dieterle, Frank, Sistare, Frank, Goodsaid, Federico, Papaluca, Marisa, Ozer, Josef S, Webb, Craig P, Baer, William, Senagore, Anthony, Schipper, Matthew J, Vonderscher, Jacky, Sultana, Stefan, Gerhold, David L, Phillips, Jonathan A, Maurer, Gérard, Carl, Kevin, Laurie, David, Harpur, Ernie, Sonee, Manisha, Ennulat, Daniela, Holder, Dan, Andrews-Cleavenger, Dina, Gu, Yi-Zhong, Thompson, Karol L, Goering, Peter L, Vidal, Jean-Marc, Abadie, Eric, Maciulaitis, Romaldas, Jacobson-Kram, David, Defelice, Albert F, Hausner, Elizabeth A, Blank, Melanie, Thompson, Aliza, Harlow, Patricia, Throckmorton, Douglas, Xiao, Shen, Xu, Nancy, Taylor, William, Vamvakas, Spiros, Flamion, Bruno, Lima, Beatriz Silva, Kasper, Peter, Pasanen, Markku, Prasad, Krishna, Troth, Sean, Bounous, Denise, Robinson-Gravatt, Denise, Betton, Graham, Davis, Myrtle A, Akunda, Jackie, McDuffie, James Eric, Suter, Laura, Obert, Leslie, Guffroy, Magalie, Pinches, Mark, Jayadev, Supriya, Blomme, Eric A, Beushausen, Sven A, Barlow, Valérie G, Collins, Nathaniel, Waring, Jeff, Honor, David, Snook, Sandra, Lee, Jinhe, Rossi, Phil, Walker, Elizabeth, Mattes, William

“…The first formal qualification of safety biomarkers for regulatory decision making marks a milestone in the application of biomarkers to drug development…”
Get full text

GFR Decline as an End Point for Clinical Trials in CKD: A View From Europe by Mol, Peter G.M., PharmD, PhD, Maciulaitis, Romaldas, MD, PharmD, PhD, Vetter, Thorsten, MD

Get full text

Evaluation of needs for therapeutic monitoring of digoxin in a tertiary hospital by Penkauskaite, Justina, Maciulaitis, Romaldas, Varanaviciene, Birute, Milvidaite, Irena, Tarutiene, Birute

“…To collect the data about the consumption of digoxin, evaluate the tendencies towards usage of this drug during 2004-2007, and to find departments, which cover…”
Get full text

Analysis of antibiotic consumption and microorganism resistance changes by Galinyte, Daiva, Maciulaitis, Romaldas, Budnikas, Vytautas, Kubilius, Darius, Varanaviciene, Birute, Vitkauskiene, Astra, Jokimas, Juozas, Jodkonis, Laimis

“…The main goal of this study was to evaluate the variation of antibiotic consumption and relation between antibiotic consumption and microorganism resistance…”
Get full text

The Glomerular Filtration Rate Estimators in the Pharmacokinetic Modelling in Acute Kidney Injury: An Observational Study by Abramavicius, Silvijus, Galaune, Vaidotas, Tunaityte, Agile, Vitkauskiene, Astra, Gumbrevicius, Gintautas, Radzeviciene, Aurelija, Maciulaitis, Romaldas

“…The glomerular filtration rate (GFR), according to which the drug dose for patients with chronic kidney disease (CKD) is adjusted, is computed with estimators…”
Get full text

Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease-Improving Global Outcomes (KDIGO) Controversies Conference by Baigent, Colin, Herrington, William G, Coresh, Josef, Landray, Martin J, Levin, Adeera, Perkovic, Vlado, Pfeffer, Marc A, Rossing, Peter, Walsh, Michael, Wanner, Christoph, Wheeler, David C, Winkelmayer, Wolfgang C, McMurray, John J V

“…Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the…”
Get more information