Search Results - "Ma, Zonghui"

Questionnaire survey of risk factors for recurrence of ocular inflammation in patients with uveitis after SARS-CoV-2 infection by Ma, Zonghui, Chi, Ying, Guo, Chunying, Zhang, Jing, Yang, Liu

“…During the COVID-19 pandemic in China, the proportion of patients with uveitis who were infected with SARS-CoV-2 increased greatly. The impact of SARS-CoV-2…”
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Lack of Association Found between Helicobacter pylori Infection and Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Retrospective Study by Li, Aimin, Huang, Senxiong, Ma, Zonghui, Xiong, Man, Xiong, Feng, Liu, Side

“…Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here…”
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Specific non-genetic IAP-based protein erasers (SNIPERs) as a potential therapeutic strategy by Ma, Zonghui, Ji, Yu, Yu, Yifan, Liang, Dailin

“…As a newly emerged technology, PROTAC (proteolysis targeting chimera) is a promising therapeutic strategy for varieties of diseases. Unlike small molecule…”
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RIPTACs: A groundbreaking approach to drug discovery by Ma, Zonghui, Bolinger, Andrew A., Zhou, Jia

“…•A groundbreaking drug discovery approach using regulated induced proximity targeting chimeras (RIPTACs) is introduced.•Proof-of-concept and preliminary…”
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Synthesis of pyrido[4,3–d]pyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization by Ma, Zonghui, Gao, Ge, Sun, Haiying

“…[Display omitted] •New methods for the synthesis of pyridopyrimidinediones and pyridopyrimidinetriones.•Critical intermediates in drug development.•Oxidative…”
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Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors by Li, Bingyan, Yang, Kang, Liang, Dailin, Jiang, Cheng, Ma, Zonghui

“…ALDH1A1, one important member of 19 ALDHs, can metabolize reactive aldehydes to their corresponding carboxylic acid derivatives and play important…”
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Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2) by Ma, Zonghui, Bolinger, Andrew A., Chen, Haiying, Zhou, Jia

“…Nuclear receptor binding SET domain proteins (NSDs) catalyze the mono- or dimethylation of histone 3 lysine 36 (H3K36me1 and H3K36me2), using…”
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DEVELOPMENT OF NANOPARTICLE-ENCAPSULATED BRD4 INHIBITORS FOR NOVEL EPIGENETIC THERAPEUTICS OF IBD by Shah, Mansi, Ma, Zonghui, Chen, Haiying, Cong, Yingzi, Zhou, Jia, Rytting, Erik, Tian, Bing

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Novel strategies targeting bromodomain-containing protein 4 (BRD4) for cancer drug discovery by Liang, Dailin, Yu, Yifan, Ma, Zonghui

“…As epigenetic readers of the histone code, BRD4 is the most extensively and thoroughly studied member of BET family, which plays a critical role in many human…”
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Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics by Ma, Zonghui, Bolinger, Andrew A, Zhou, Jia, Tian, Bing

“…Inflammatory bowel diseases (IBDs) are debilitating chronic inflammatory disorders with increasing prevalence worldwide. Epigenetic regulator…”
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Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity by Ma, Zonghui, Jiang, Ling, Li, Bingyan, Liang, Dailin, Feng, Yu, Liu, Li, Jiang, Cheng

“…Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity…”
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DEVELOPMENT OF NANOPARTICLE-ENCAPSULATED BRD4 INHIBITORS FOR NOVEL EPIGENETIC THERAPEUTICS OF IBD by Shah, Mansi, Ma, Zonghui, Chen, Haiying, Cong, Yingzi, Zhou, Jia, Rytting, Erik, Tian, Bing

“…Abstract BACKGROUND Inflammatory bowel diseases (IBD) are chronic intestinal disorders that are typically categorized as one of two subtypes: Crohn's disease…”
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Development of Novel Anticancer Agents with a Scaffold of Tetrahydropyrido[4,3‑d]pyrimidine-2,4-dione by Ma, Zonghui, Gao, Ge, Fang, Kunsen, Sun, Haiying

“…ONC201 is a small molecular anticancer agent currently in multiple Phase II clinical trials. Based on the pharmacophore of ONC201, a series of small molecular…”
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174 BRD4 AS A POTENTIAL THERAPEUTIC TARGET FOR CROHN'S DISEASEASSOCIATED FIBROSIS by McAninch, Christina, Chulkina, Marina, Ma, Zonghui, McAninch, Steven B., Edwards, Rachael M., Seideneck, Ashley, Panganiban, Ronaldo P., Chen, Haiying, Koltun, Walter, Yochum, Gregory, Tian, Bing, Zhou, Jia, Pinchuk, Irina V.

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IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors by Wu, Shwu-Yuan, Lai, Hsien-Tsung, Sanjib Banerjee, N, Ma, Zonghui, Santana, Juan F, Wei, Shuguang, Liu, Xisheng, Zhang, Meirong, Zhan, Jian, Chen, Haiying, Posner, Bruce, Chen, Yadong, Price, David H, Chow, Louise T, Zhou, Jia, Chiang, Cheng-Ming

“…Compounds binding to the bromodomains of bromodomain and extra-terminal (BET) family proteins, particularly BRD4, are promising anticancer agents…”
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Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity by Ma, Zonghui, Jiang, Ling, Li, Guoxin, Liang, Dailin, Li, Luanfeng, Liu, Li, Jiang, Cheng

“…Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 inhibitors with glucose consumption improving…”
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Novel hydrazone moiety-bearing aminopyrimidines as selective inhibitors of epidermal growth factor receptor T790M mutant by Qin, Mingze, Wang, Tingting, Xu, Boxuan, Ma, Zonghui, Jiang, Nan, Xie, Hongbo, Gong, Ping, Zhao, Yanfang

“…The epidermal growth factor receptor (EGFR) T790M mutant is found in approximately 50% of clinically acquired resistance to gefitinib among patients with…”
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A Study on Evaluation and Application of Snowmelt Performance of Anti-Icing Asphalt Pavement by Zheng, Mulian, Wu, Shujuan, Wang, Chongtao, Li, Yifeng, Ma, Zonghui, Peng, Lei

“…This paper presents a quantitative estimation of anti-icing asphalt mixture snow-melting performance and provides the application guidance for the mixture…”
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Synthesis and Anti-Hepatitis B Virus Evaluation of 7-Methoxy-3-heterocyclic quinolin-6-ols by Liu, Yajing, Feng, Guobing, Ma, Zonghui, Xu, Chen, Guo, Zhuang, Gong, Ping, Xu, Liying

“…A series of novel 7‐methoxy‐3‐heterocyclic quinolin‐6‐ol derivatives were synthesized and evaluated for their anti‐hepatitis B virus (HBV) activities and…”
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