Children’s vaccines do not induce cross reactivity against SARS-CoV

In contrast with adults, children infected by severe acute respiratory syndrome-corona virus (SARS-CoV) develop milder clinical symptoms. Because of this, it is speculated that children vaccinated with various childhood vaccines might develop cross immunity against SARS-CoV. Antisera and T cells fro...

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Bibliographic Details
Published in:	Journal of clinical pathology Vol. 60; no. 2; pp. 208 - 211
Main Authors:	Yu, Yang, Jin, Huali, Chen, Ze, Yu, Qingling L, Ma, Yijie J, Sun, Xiaolin L, Wang, Bin
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01-02-2007 BMJ BMJ Publishing Group LTD BMJ Group
Subjects:	Animals Antibodies, Viral - blood Antigens Biological and medical sciences Cell growth Child Child, Preschool Children & youth Cross Reactions - immunology Enzyme-Linked Immunosorbent Assay - methods Hepatitis Human viral diseases Humans Immune Sera - immunology Immunization Immunoglobulins Infant Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Lymphocytes Measles Medical sciences Mice Mice, Inbred C57BL Mumps Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques SARS SARS coronavirus SARS CoV SARS Virus - immunology severe acute respiratory syndrome Severe Acute Respiratory Syndrome - immunology Short Report Streptococcus infections T-Lymphocytes - immunology Tetanus Vaccines Vaccines - immunology Viral diseases Viral diseases of the respiratory system and ent viral diseases Viruses Whooping cough China Human Lung disease Respiratory disease Severe acute respiratory syndrome Interference Vaccine Infection Virus Prevention Immunoprophylaxis Anatomic pathology Coronavirus Viral disease Cross reaction Coronaviridae Child Nidovirales
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Summary:	In contrast with adults, children infected by severe acute respiratory syndrome-corona virus (SARS-CoV) develop milder clinical symptoms. Because of this, it is speculated that children vaccinated with various childhood vaccines might develop cross immunity against SARS-CoV. Antisera and T cells from mice immunised with various vaccines were used to determine whether they developed cross reactivity against SARS-CoV. The results showed no marked cross reactivity against SARS-CoV, which implies that the reduced symptoms among children infected by SARS-CoV may be caused by other factors.
Bibliography:	istex:7E7CEB6A9DD25B89313166206CE8FF6D85E99E28 PMID:17264247 Correspondence to:  Dr B Wang  State Key Laboratory for Agro-Biotechnology, College of Biological Science, China Agricultural University, 2 Yuanmingyuan Xi Road, Beijing 100094, China; bwang3@cau.edu.cn ark:/67375/NVC-TJLTHM4J-2 local:0600208 href:jclinpath-60-208.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9746 1472-4146
DOI:	10.1136/jcp.2006.038893