Search Results - "Ma, Stephanie"

Biology and clinical implications of CD133+ liver cancer stem cells by Ma, Stephanie

“…Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, accounting for 80%–90% of all liver cancers. The disease ranks as the…”
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Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma by Loong, Jane Hc, Wong, Tin-Lok, Tong, Man, Sharma, Rakesh, Zhou, Lei, Ng, Kai-Yu, Yu, Hua-Jian, Li, Chi-Han, Man, Kwan, Lo, Chung-Mau, Guan, Xin-Yuan, Lee, Terence K, Yun, Jing-Ping, Ma, Stephanie Ky

“…Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Tumor cells respond to the cytotoxic…”
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Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children by Goldenberg, Joshua Z, Ma, Stephanie S Y, Saxton, Jane D, Martzen, Mark R, Vandvik, Per O, Thorlund, Kristian, Guyatt, Gordon H, Johnston, Bradley C

“…Antibiotics are widely prescribed; however they can cause disturbances in gastrointestinal flora which may lead to reduced resistance to pathogens such as…”
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Probiotics for the Prevention of Clostridium difficile―Associated Diarrhea: A Systematic Review and Meta-analysis by JOHNSTON, Bradley C, MA, Stephanie S. Y, GOLDENBERG, Joshua Z, THORLUND, Kristian, VANDVIK, Per O, LOEB, Mark, GUYATT, Gordon H

“…Antibiotic treatment may disturb the resistance of gastrointestinal flora to colonization. This may result in complications, the most serious of which is…”
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Reprogramming of central carbon metabolism in cancer stem cells by Wong, Tin Lok, Che, Noélia, Ma, Stephanie

“…Cancer metabolism has been studied for years and adopted in the clinic for monitoring disease progression and therapy response. Despite our growing knowledge…”
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Solar-Powered Charging Networks for Electric Vehicles by Erickson, Larry, Ma, Stephanie

“…The cost of solar-generated electricity and battery costs have been decreasing significantly. These developments can be combined to introduce solar-powered…”
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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids by Hu, Huili, Gehart, Helmuth, Artegiani, Benedetta, LÖpez-Iglesias, Carmen, Dekkers, Florijn, Basak, Onur, van Es, Johan, Chuva de Sousa Lopes, Susana M., Begthel, Harry, Korving, Jeroen, van den Born, Maaike, Zou, Chenhui, Quirk, Corrine, Chiriboga, Luis, Rice, Charles M., Ma, Stephanie, Rios, Anne, Peters, Peter J., de Jong, Ype P., Clevers, Hans

“…The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The “oval cell” response emanates from…”
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The Role of Cancer-Associated Fibroblast as a Dynamic Player in Mediating Cancer Stemness in the Tumor Microenvironment by Loh, Jia Jian, Ma, Stephanie

“…The enrichment of cancer-associated fibroblast (CAFs) in a tumor microenvironment (TME) cultivates a pro-tumorigenic niche via aberrant paracrine signaling and…”
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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening by Yan, Helen H.N., Siu, Hoi Cheong, Law, Simon, Ho, Siu Lun, Yue, Sarah S.K., Tsui, Wai Yin, Chan, Dessy, Chan, April S., Ma, Stephanie, Lam, Ka On, Bartfeld, Sina, Man, Alice H.Y., Lee, Bernard C.H., Chan, Annie S.Y., Wong, Jason W.H., Cheng, Priscilla S.W., Chan, Anthony K.W., Zhang, Jiangwen, Shi, Jue, Fan, Xiaodan, Kwong, Dora L.W., Mak, Tak W., Yuen, Siu Tsan, Clevers, Hans, Leung, Suet Yi

“…Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique…”
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Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib by Tong, Man, Che, Noélia, Zhou, Lei, Luk, Steve T., Kau, Phillis W., Chai, Stella, Ngan, Elly S., Lo, Chung-Mau, Man, Kwan, Ding, Jin, Lee, Terence K., Ma, Stephanie

“…[Display omitted] •ANXA3 confers HCC cells with the ability to resist sorafenib.•ANXA3 is enriched in sorafenib-resistant HCC.•ANXA3 activates autophagy and…”
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Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling by Lau, Eunice Yuen Ting, Lo, Jessica, Cheng, Bowie Yik Ling, Ma, Mark Kin Fai, Lee, Joyce Man Fong, Ng, Johnson Kai Yu, Chai, Stella, Lin, Chi Ho, Tsang, Suk Ying, Ma, Stephanie, Ng, Irene Oi Lin, Lee, Terence Kin Wah

“…Like normal stem cells, tumor-initiating cells (T-ICs) are regulated extrinsically within the tumor microenvironment. Because HCC develops primarily in the…”
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Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma by Ming, Xiao-Yan, Fu, Li, Zhang, Li-Yi, Qin, Yan-Ru, Cao, Ting-Ting, Chan, Kwok Wah, Ma, Stephanie, Xie, Dan, Guan, Xin-Yuan

“…Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG…”
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IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma by Cheng, Bowie Y, Lau, Eunice Y, Leung, Hoi-Wing, Leung, Carmen Oi-Ning, Ho, Nicole P, Gurung, Shilpa, Cheng, Lily K, Lin, Chi Ho, Lo, Regina Cheuk-Lam, Ma, Stephanie, Ng, Irene Oi-Lin, Lee, Terence K

“…Frequent relapse and drug resistance in patients with hepatocellular carcinoma (HCC) can be attributed to the existence of tumor-initiating cells (TIC) within…”
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Clinicopathologic features, tumor immune microenvironment and genomic landscape of Epstein-Barr virus-associated intrahepatic cholangiocarcinoma by Huang, Yu-Hua, Zhang, Chris Zhi-yi, Huang, Qun-Sheng, Yeong, Joe, Wang, Fang, Yang, Xia, He, Yang-Fan, Zhang, Xiao-Long, Zhang, Hua, Chen, Shi-Lu, Zheng, Yin-Li, Deng, Ru, Lin, Cen-Shan, Yang, Ming-Ming, Li, Yan, Jiang, Chen, Kin-Wah Lee, Terence, Ma, Stephanie, Zeng, Mu-Sheng, Yun, Jing-Ping

“…Little is known about Epstein-Barr virus (EBV)-associated intrahepatic cholangiocarcinoma (EBVaICC) because of its rarity. We aimed to comprehensively…”
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Protocols to culture and harvest hepatic tumor organoids for metabolic assays by Tong, Man, Ma, Stephanie

“…Three-dimensional organoids, which resemble the pathophysiology and structural architecture of the original tissues, are a preferable in vitro model system for…”
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Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma by Leung, Carmen Oi Ning, Yang, Yang, Leung, Rainbow Wing Hei, So, Karl Kam Hei, Guo, Hai Jun, Lei, Martina Mang Leng, Muliawan, Gregory Kenneth, Gao, Yuan, Yu, Qian Qian, Yun, Jing Ping, Ma, Stephanie, Zhao, Qian, Lee, Terence Kin Wah

“…Increasing evidence has demonstrated that drug resistance can be acquired in cancer cells by kinase rewiring, which is an obstacle for efficient cancer…”
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miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1 by Ma, Stephanie, Tang, Kwan Ho, Chan, Yuen Piu, Lee, Terence K., Kwan, Pak Shing, Castilho, Antonia, Ng, Irene, Man, Kwan, Wong, Nathalie, To, Ka-Fai, Zheng, Bo-Jian, Lai, Paul B.S., Lo, Chung Mau, Chan, Kwok Wah, Guan, Xin-Yuan

“…A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells within a tumor, called tumor-initiating cells (TICs) or cancer stem…”
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ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer by Wong, Tin-Lok, Loh, Jia-Jian, Lu, Shixun, Yan, Helen H. N., Siu, Hoi Cheong, Xi, Ren, Chan, Dessy, Kam, Max J. F., Zhou, Lei, Tong, Man, Copland, John A., Chen, Leilei, Yun, Jing-Ping, Leung, Suet Yi, Ma, Stephanie

“…Targetable drivers governing 5-fluorouracil and cisplatin (5FU + CDDP) resistance remain elusive due to the paucity of physiologically and therapeutically…”
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Signal transducer and activator of transcription 3‐mediated CD133 up‐regulation contributes to promotion of hepatocellular carcinoma by Won, Cheolhee, Kim, Byung‐Hak, Yi, Eun Hee, Choi, Kyung‐Ju, Kim, Eun‐Kyung, Jeong, Jong‐Min, Lee, Jae‐Ho, Jang, Ja‐June, Yoon, Jung‐Hwan, Jeong, Won‐Il, Park, In‐Chul, Kim, Tae Woo, Bae, Sun Sik, Factor, Valentina M., Ma, Stephanie, Thorgeirsson, Snorri S., Lee, Yun‐Han, Ye, Sang‐Kyu

“…Enhanced expression of the cancer stem cell (CSC) marker, CD133, is closely associated with a higher rate of tumor formation and poor prognosis in…”
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Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells by Ma, Stephanie, Chan, Kwok–Wah, Hu, Liang, Lee, Terence Kin–Wah, Wo, Jana Yim–Hung, Ng, Irene Oi–Lin, Zheng, Bo–Jian, Guan, Xin–Yuan

“…Background & Aims: Recent efforts in stem cell biology suggest that tumors are organized in a hierarchy of heterogeneous cell populations and that the…”
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