Search Results - "Ma, Songling"

Structural identification of vasodilator binding sites on the SUR2 subunit by Ding, Dian, Wu, Jing-Xiang, Duan, Xinli, Ma, Songling, Lai, Lipeng, Chen, Lei

“…ATP-sensitive potassium channels (K ATP ), composed of Kir6 and SUR subunits, convert the metabolic status of the cell into electrical signals. Pharmacological…”
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DORN1 and GORK regulate stomatal closure in Arabidopsis mediated by volatile organic compound ethyl vinyl ketone by Gong, Junqing, Wang, Zhaoyuan, Guo, Zhujuan, Yao, Lijuan, Zhao, Chuanfang, Lin, Sheng, Ma, Songling, Shen, Yingbai

“…Evk (ethyl vinyl ketone) is a signal substance for plant defense, but little is known about how evk mediates stomatal closure. Through stomatal biology…”
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Application scenario-oriented molecule generation platform developed for drug discovery by Zheng, Lianjun, Shi, Fangjun, Peng, Chunwang, Xu, Min, Fan, Fangda, Li, Yuanpeng, Zhang, Lin, Du, Jiewen, Wang, Zonghu, Lin, Zhixiong, Sun, Yina, Deng, Chenglong, Duan, Xinli, Wei, Lin, Zhao, Chuanfang, Fang, Lei, Zhang, Peiyu, Ma, Songling, Lai, Lipeng, Yang, Mingjun

“…[Display omitted] •Here we present an application scenario-oriented platform (ID4Idea) for molecule generation in different scenarios of drug discovery. This…”
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Clinical management of lung adenocarcinoma patients with HER2 V659E mutation by Jia, Ziqi, Liang, Naixin, Wang, Yadong, Wang, Yanyu, Ye, Junyi, Wang, Weiwei, Li, Bing, Han-Zhang, Han, Zhao, Jiaxing, Zhang, Xiaochun, Peng, Feng, Chen, Fengxia, Chen, Xueqin, Lu, Yan, Ying, Shenpeng, Dp, Wu, Zhang, Xinwei, Ma, Caixia, Lai, Lipeng, Ma, Songling

“…Abstract only e21521 Background: ERBB2 mutations, mostly affecting the kinase domain (KD), were later found in the transmembrane domain (TMD), most frequently…”
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Incorporation of Hydrogen Bond Angle Dependency into the Generalized Solvation Free Energy Density Model by Ma, Songling, Hwang, Sungbo, Lee, Sehan, Acree, William E, No, Kyoung Tai

“…To describe the physically realistic solvation free energy surface of a molecule in a solvent, a generalized version of the solvation free energy density…”
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Discovery of a small-molecule inhibitor of Dvl–CXXC5 interaction by computational approaches by Ma, Songling, Choi, Jiwon, Jin, Xuemei, Kim, Hyun-Yi, Yun, Ji-Hye, Lee, Weontae, Choi, Kang-Yell, No, Kyoung Tai

“…The Wnt/β-catenin signaling pathway plays a significant role in the control of osteoblastogenesis and bone formation. CXXC finger protein 5 (CXXC5) has been…”
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Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies by Choi, Jiwon, Ma, SongLing, Kim, Hyun-Yi, Yun, Ji-Hye, Heo, Jung-Nyoung, Lee, Weontae, Choi, Kang-Yell, No, Kyoung Tai

“…[Display omitted] The Dishevelled (Dvl) protein, which conveys signals from receptors to the downstream effectors, is a critical constituent of the…”
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PMFF: Development of a Physics-Based Molecular Force Field for Protein Simulation and Ligand Docking by Hwang, Sung Bo, Lee, Chang Joon, Lee, Sehan, Ma, Songling, Kang, Young-Mook, Cho, Kwang Hwi, Kim, Su-Yeon, Kwon, Oh Young, Yoon, Chang No, Kang, Young Kee, Yoon, Jeong Hyeok, Nam, Ky-Youb, Kim, Seong-Gon, In, Youngyong, Chai, Han Ha, Acree, William E, Grant, J. Andrew, Gibson, Ken D, Jhon, Mu Shik, Scheraga, Harold A, No, Kyoung Tai

“…The physics-based molecular force field (PMFF) was developed by integrating a set of potential energy functions in which each term in an intermolecular…”
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Application scenario-oriented molecular generation platform developed for drug discovery by Zheng, Lianjun, Shi, Fangjun, Peng, Chunwang, Xu, Min, Fan, Fangda, Li, Yuanpeng, Zhang, Lin, Du, Jiewen, Wang, Zonghu, Lin, Zhixiong, Sun, Yina, Deng, Chenglong, Duan, Xinli, Wei, Lin, Zhao, Chuanfang, Fang, Lei, Zhang, Peiyu, Ma, Songling, Lai, Lipeng, Yang, Mingjun

“…Design of molecules for candidate compound selection is one of the central challenges in drug discovery due to the complexity of chemical space and requirement…”
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Structural insight into the antiprion compound inhibition mechanism of native prion folding over misfolding by Choi, Jiwon, Govindaraj, Rajiv Gandhi, Hyeon, Jae Wook, Lee, Kyungro, Ma, SongLing, Kim, Su Yeon, Lee, Jeongmin, No, Kyoung Tai

“…Transition of a physiological folded prion (PrPC) into a pathogenic misfolded prion (PrPSc) causes lethal neurodegenerative disorders and prion diseases…”
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HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma by Jia, Ziqi, Xing, Jiahua, Li, Ji, Wang, Weiwei, Wang, Yadong, Song, Yang, Yang, Xiaoying, Xue, Jianchao, Ye, Junyi, Li, Bing, Han-Zhang, Han, Zhao, Jiaxing, Zhang, Xiaochun, Peng, Feng, Chen, Fengxia, Chen, Xueqin, Lu, Yan, Ying, Shenpeng, Wu, Dongping, Zhang, Xinwei, Ma, Caixia, Lai, Lipeng, Ma, Songling, Liang, Dianjing, Liu, Peng, Li, Xiaoguang, Liang, Naixin, Li, Shanqing

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