Search Results - "Ma, Ngai Ling"

A Small-Molecule Dengue Virus Entry Inhibitor by WANG, Qing-Yin, PATEL, Sejal J, MEE KIAN POH, WAI YEE PHONG, KELLER, Thomas H, JACOBY, Edgar, VASUDEVAN, Subhash G, VANGREVELINGHE, Eric, HAO YING XU, RAO, Ranga, JABER, Deana, SCHUL, Wouter, FENG GU, HEUDI, Olivier, NGAI LING MA

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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis by Mak, Puiying A, Rao, Srinivasa P. S, Ping Tan, Mai, Lin, Xiuhua, Chyba, Jason, Tay, Joann, Ng, Seow Hwee, Tan, Bee Huat, Cherian, Joseph, Duraiswamy, Jeyaraj, Bifani, Pablo, Lim, Vivian, Lee, Boon Heng, Ling Ma, Ngai, Beer, David, Thayalan, Pamela, Kuhen, Kelli, Chatterjee, Arnab, Supek, Frantisek, Glynne, Richard, Zheng, Jun, Boshoff, Helena I, Barry, Clifton E, Dick, Thomas, Pethe, Kevin, Camacho, Luis R

“…Growing evidence suggests that the presence of a subpopulation of hypoxic non-replicating, phenotypically drug-tolerant mycobacteria is responsible for the…”
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Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria by Nilar, Shahul H, Lakshminarayana, Suresh B, Ma, Ngai Ling, Keller, Thomas H, Blasco, Francesca, Smith, Paul W

“…Poor pharmacokinetic and toxicity profiles are major reasons for the low rate of advancing lead drug candidates into efficacy studies. The In-silico prediction…”
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Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents by Kondreddi, Ravinder Reddy, Jiricek, Jan, Rao, Srinivasa P. S, Lakshminarayana, Suresh B, Camacho, Luis R, Rao, Ranga, Herve, Maxime, Bifani, Pablo, Ma, Ngai Ling, Kuhen, Kelli, Goh, Anne, Chatterjee, Arnab K, Dick, Thomas, Diagana, Thierry T, Manjunatha, Ujjini H, Smith, Paul W

“…Indole-2-carboxamides have been identified as a promising class of antituberculosis agents from phenotypic screening against mycobacteria. One of the hits,…”
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Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents by Ng, Pearly Shuyi, Manjunatha, Ujjini H., Rao, Srinivasa P.S., Camacho, Luis R., Ma, Ngai Ling, Herve, Maxime, Noble, Christian G., Goh, Anne, Peukert, Stefan, Diagana, Thierry T., Smith, Paul W., Kondreddi, Ravinder Reddy

“…Pyridone 1 was identified from a high-throughput cell-based phenotypic screen against Mycobacterium tuberculosis (Mtb) including multi-drug resistant…”
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Fishing the Target of Antitubercular Compounds: In Silico Target Deconvolution Model Development and Validation by Prathipati, Philip, Ma, Ngai Ling, Manjunatha, Ujjini H, Bender, Andreas

“…An in silico target prediction protocol for antitubercular (antiTB) compounds has been proposed in this work. This protocol is the extension of a recently…”
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Conformational Analysis of (±)-(1,1′-Biindene)-3,3′-dione, 2,2′,3,3′-Tetrahydro-(1,1′-binaphthalene)-4,4′(1H,1′H)-dione, and (1,1′-Bibenzosuberene)-5,5′-dione by Lam, Yulin, Ma, Ngai Ling, Huang, Hsing-Hua, Liang, Eping

“…The dipole moments of (±)-(1,1′-biindene)-3,3′-dione 1, (±)-2,2′,3,3′-tetrahydro-(1,1′-binaphthalene)-4,4′(1H,1′H)-dione 2, and…”
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Peptide Inhibitors of West Nile NS3 Protease:  SAR Study of Tetrapeptide Aldehyde Inhibitors by Knox, John E, Ma, Ngai Ling, Yin, Zheng, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K. R, Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Lim, Siew Pheng, Vasudevan, Subhash G, Keller, Thomas H

“…A series of inhibitors related to the benzoyl-norleucine-lysine-arginine-arginine (Bz-nKRR) tetrapeptide aldehyde was synthesized. When evaluated against the…”
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Conformation Preferences of 1,2-Dichlorotetranitroethane by Lam, Yulin, Ma, Ngai Ling, Huang, Hsing Hua, Wang, Li

“…The dipole moments of 1,2-dichlorotetranitroethane in carbon tetrachloride and benzene show that the compound favors the gauche conformer in solution-state…”
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Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate by Nzila, Alexis, Rottmann, Matthias, Chitnumsub, Penchit, Kiara, Stevens M, Kamchonwongpaisan, Sumalee, Maneeruttanarungroj, Cherdsak, Taweechai, Supannee, Yeung, Bryan K. S, Goh, Anne, Lakshminarayana, Suresh B, Zou, Bin, Wong, Josephine, Ma, Ngai Ling, Weaver, Margaret, Keller, Thomas H, Dartois, Veronique, Wittlin, Sergio, Brun, Reto, Yuthavong, Yongyuth, Diagana, Thierry T

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Conformation Preferences of 1,1′-Bis(1-amino-4,4-dicyclopropyl-2,3-diaza-1,3-butadienyl) by Lam, Yulin, Ma, Ngai Ling, Liang, Eping

“…The reaction of dicyclopropyl ketone with hydrazine sulfate and sodium cyanide afforded 1,1′-bis(1-amino-4,4-dicyclopropyl-2,3-diaza-1,3-butadienyl). The…”
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Yellow fever virus NS3 protease: peptide-inhibition studies by Lohr, Kristina, Knox, John E, Phong, Wai Yee, Ma, Ngai Ling, Yin, Zheng, Sampath, Aruna, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Rao, K. R. Ranga, Wang, Gang, Vasudevan, Subhash G, Keller, Thomas H, Lim, Siew Pheng

“…Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore 138670 Correspondence Siew Pheng Lim siew_pheng.lim{at}novartis.com A…”
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Cation−π Interactions in Sodiated Phenylalanine Complexes:  Is Phenylalanine in the Charge-Solvated or Zwitterionic Form? by Siu, Fung Ming, Ma, Ngai Ling, Tsang, Chun Wai

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Preclinical Evaluation of the Antifolate QN254, 5-Chloro-N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate by NZILA, Alexis, ROTTMANN, Matthias, BIN ZOU, WONG, Josephine, NGAI LING MA, WEAVER, Margaret, KELLER, Thomas H, DARTOIS, Veronique, WITTLIN, Sergio, BRUN, Reto, YUTHAVONG, Yongyuth, DIAGANA, Thierry T, CHITNUMSUB, Penchit, KIARA, Stevens M, KAMCHONWONGPAISAN, Sumalee, MANEERUTTANARUNGROJ, Cherdsak, TAWEECHAI, Supannee, YEUNG, Bryan K. S, GOH, Anne, LAKSHMINARAYANA, Suresh B

“…Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic,…”
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Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors by Yin, Zheng, Patel, Sejal J., Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K.R., Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Knox, John E., Ma, Ngai Ling, Ehrhardt, Claus, Lim, Siew Pheng, Vasudevan, Subhash G., Keller, Thomas H.

“…With the aim of discovering potent and selective dengue NS3 protease inhibitors, we systematically synthesized and evaluated a series of tetrapeptide aldehydes…”
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Absolute Potassium Cation Affinities (PCAs) in the Gas Phase by Lau, Justin Kai-Chi, Wong, Carrie Hoi Shan, Ng, Po Shan, Siu, Fung Ming, Ma, Ngai Ling, Tsang, Chun Wai

“…The potassium cation affinities (PCAs) of 136 ligands (20 classes) in the gas phase were established by hybrid density functional theory calculations (B3‐LYP…”
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Differentiation of isomeric polyaromatic hydrocarbons by electrospray Ag(I) cationization mass spectrometry by Ming Ng, Kwan, Ling Ma, Ngai, Wai Tsang, Chun

“…Abundant Ag(I)‐cationized complexes of 13 polyaromatic hydrocarbons (PAHs), [Ag+PAH]+ and [Ag+2(PAH)]+, were readily generated by electrospray ionization…”
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High resolution electron energy loss spectroscopy study of clean, air-exposed and methanol-dosed Ge(1 0 0) surface by Lim, Chee Wei, Soon, Jia Mei, Ma, Ngai Ling, Chen, Wei, Loh, Kian Ping

“…Using high resolution electron energy loss spectroscopy (HREELS), we have characterized the fingerprint spectra of clean, hydrogenated, methanol-dosed and…”
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Finding new medicines for flaviviral targets by Keller, Thomas H, Chen, Yen Liang, Knox, John E, Lim, Siew Pheng, Ma, Ngai Ling, Patel, Sejal J, Sampath, Aruna, Wang, Qing Yin, Yin, Zheng, Vasudevan, Subhash G

“…With the incidence of dengue fever increasing all over the world, there is an urgent need for therapies. While drug discovery for any disease is a long and…”
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Kinetics of the Initial Oxidation of the (0001) 6H−SiC 3 × 3 Reconstructed Surface by Soon, Jia Mei, Ma, Ngai Ling, Loh, Kian Ping, Sakata, Osami

“…Using first-principle calculations, the mechanism of oxygen insertion into the (0001) 6H−silicon carbide 3 × 3 reconstructed surface is investigated. The…”
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