Search Results - "Ma, Jiyan"

The role of cofactors in prion propagation and infectivity by Ma, Jiyan

“…The simultaneous propagation of protease-resistant PrPSc and prion infectivity in sPMCA provides strong evidence supporting the prion hypothesis [5]. Because…”
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Generating a Prion with Bacterially Expressed Recombinant Prion Protein by Wang, Fei, Wang, Xinhe, Yuan, Chong-Gang, Ma, Jiyan

“…The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the infectivity of prion disease. Using recombinant murine PrP…”
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Preparation,characterization and photocatalytic properties of BiOBr/ZnO composites by Geng, Yanling, Li, Na, Ma, Jiyan, Sun, Zhenhai

“…BiOBr/ZnO composite photocatalysts were prepared by a simple hydrothermal method. The as-prepared samples were characterized by X-ray diffraction(XRD),…”
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Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids by Deleault, Nathan R, Piro, Justin R, Walsh, Daniel J, Wang, Fei, Ma, Jiyan, Geoghegan, James C, Supattapone, Surachai

“…Infectious prions containing the pathogenic conformer of the mammalian prion protein (PrPSc) can be produced de novo from a mixture of the normal conformer…”
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Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration by Wang, Xinhe, Becker, Katelyn, Levine, Nathan, Zhang, Michelle, Lieberman, Andrew P, Moore, Darren J, Ma, Jiyan

“…Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson's disease (PD). The…”
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Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints by Minikel, Eric Vallabh, Zhao, Hien T, Le, Jason, O’Moore, Jill, Pitstick, Rose, Graffam, Samantha, Carlson, George A, Kavanaugh, Michael P, Kriz, Jasna, Kim, Jae Beom, Ma, Jiyan, Wille, Holger, Aiken, Judd, McKenzie, Deborah, Doh-ura, Katsumi, Beck, Matthew, O’Keefe, Rhonda, Stathopoulos, Jacquelyn, Caron, Tyler, Schreiber, Stuart L, Carroll, Jeffrey B, Kordasiewicz, Holly B, Cabin, Deborah E, Vallabh, Sonia M

“…Abstract Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic hypothesis in prion disease. We recently showed that…”
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Recombinant Mammalian Prions: The “Correctly” Misfolded Prion Protein Conformers by Ma, Jiyan, Zhang, Jingjing, Yan, Runchuan

“…Generating a prion with exogenously produced recombinant prion protein is widely accepted as the ultimate proof of the prion hypothesis. Over the years, a…”
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Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA by Becker, Katelyn, Wang, Xinhe, Vander Stel, Kayla, Chu, Yaping, Kordower, Jeffrey, Ma, Jiyan

“…Alpha synuclein (α-syn) is central to the pathogenesis of a group of neurodegenerative disorders known as synucleinopathies, including Parkinson’s disease…”
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Immunotherapy against Prion Disease by Ma, Yue, Ma, Jiyan

“…The term "prion disease" encompasses a group of neurodegenerative diseases affecting both humans and animals. Currently, there is no effective therapy and all…”
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Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies by Bargar, Connor, Wang, Wen, Gunzler, Steven A, LeFevre, Alexandra, Wang, Zerui, Lerner, Alan J, Singh, Neena, Tatsuoka, Curtis, Appleby, Brian, Zhu, Xiongwei, Xu, Rong, Haroutunian, Vahram, Zou, Wen-Quan, Ma, Jiyan, Chen, Shu G

“…Definitive diagnosis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) relies on postmortem finding of disease-associated alpha-synuclein (αSyn )…”
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Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions by Deleault, Nathan R, Walsh, Daniel J, Piro, Justin R, Wang, Fei, Wang, Xinhe, Ma, Jiyan, Rees, Judy R, Supattapone, Surachai

“…Prions containing misfolded prion protein (PrP Sᶜ) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification…”
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Barriers to and Facilitators of the Implementation of a Micronutrient Powder Program for Children: A Systematic Review Based on the Consolidated Framework for Implementation Research by Sun, Yinuo, Ma, Jiyan, Wei, Xiaolin, Dong, Jingya, Wu, Shishi, Huang, Yangmu

“…As one of the most cost-effective investments for improving child nutrition, micronutrient powder (MNP) has been widely used in many countries to underpin the…”
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Prion disease and the 'protein-only hypothesis' by Ma, Jiyan, Wang, Fei

“…Prion disease is the only naturally occurring infectious protein misfolding disorder. The chemical nature of the infectious agent has been debated for more…”
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Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles by Graham, Stewart F, Rey, Nolwen L, Yilmaz, Ali, Kumar, Praveen, Madaj, Zachary, Maddens, Michael, Bahado-Singh, Ray O, Becker, Katelyn, Schulz, Emily, Meyerdirk, Lindsay K, Steiner, Jennifer A, Ma, Jiyan, Brundin, Patrik

“…Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well…”
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Prion protein amino acid sequence influences formation of authentic synthetic PrPSc by Block, Alyssa J., York, Taylor C., Benedict, Romilly, Ma, Jiyan, Bartz, Jason C.

“…Synthetic prions, generated de novo from minimal, non-infectious components, cause bona fide prion disease in animals. Transmission of synthetic prions to…”
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Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion by Abskharon, Romany, Wang, Fei, Wohlkonig, Alexandre, Ruan, Juxin, Soror, Sameh, Giachin, Gabriele, Pardon, Els, Zou, Wenquan, Legname, Giuseppe, Ma, Jiyan, Steyaert, Jan

“…Prion or PrPSc is the proteinaceous infectious agent causing prion diseases in various mammalian species. Despite decades of research, the structural basis for…”
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Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol by JIYAN MA, LINDQUIST, Susan

“…A rare conformation of the prion protein, PrPSc, is found only in mammals with transmissible prion diseases and represents either the infectious agent itself…”
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Access to DTP-Based Combination Vaccines in Asia-Pacific Countries between 2019 and 2022 by Ma, Jiyan, Sun, Yinuo, Cui, Yuxuan, Dong, Jingya, Huang, Yangmu

“…The Asia-Pacific countries are highly diverse in health and economic conditions that may impact vaccine access and uptake. Our study aimed to characterize…”
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Neurotoxicity and Neurodegeneration When PrP Accumulates in the Cytosol by Ma, Jiyan, Wollmann, Robert, Lindquist, Susan

“…Changes in prion protein (PrP) folding are associated with fatal neurodegenerative disorders, but the neurotoxic species is unknown. Like other proteins that…”
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Wild-Type PrP and a Mutant Associated with Prion Disease are Subject to Retrograde Transport and Proteasome Degradation by Ma, Jiyan, Lindquist, Susan

“…The cytoplasm seems to provide an environment that favors conversion of the prion protein (PrP) to a form with the physical characteristics of the…”
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