Search Results - "Ma, Huaxian"

LGALS1 acts as a pro-survival molecule in AML by Ruvolo, Peter P., Ma, Huaxian, Ruvolo, Vivian R., Zhang, Xiaorui, Post, Sean M., Andreeff, Michael

“…The galectin LGALS1 is a glycan binding protein that regulates intracellular (e.g. signal transduction) and extracellular processes (e.g. immunity, leukocyte…”
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Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL by Piya, Sujan, Yang, Yaling, Bhattacharya, Seemana, Sharma, Priyanka, Ma, Huaxian, Mu, Hong, He, Hua, Ruvolo, Vivian, Baran, Natalia, Davis, R. Eric, Jain, Abhinav K., Konopleava, Marina, Kantarjian, Hagop, Andreeff, Michael, You, M. James, Borthakur, Gautam

“…The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute…”
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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3 -ITD acute myeloid leukemia by Post, Sean M, Ma, Huaxian, Malaney, Prerna, Zhang, Xiaorui, Aitken, Marisa J L, Mak, Po Yee, Ruvolo, Vivian R, Yasuhiro, Tomoko, Kozaki, Ryohei, Chan, Lauren E, Ostermann, Lauren B, Konopleva, Marina, Carter, Bing Z, DiNardo, Courtney, Andreeff, Michael D, Khoury, Joseph D, Ruvolo, Peter P

“…FMS-like Tyrosine Kinase 3 (FLT3) mutation is associated with poor survival in acute myeloid leukemia (AML). The specific Anexelekto/MER Tyrosine Kinase (AXL)…”
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Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas by Gallardo, Miguel, Malaney, Prerna, Aitken, Marisa J L, Zhang, Xiaorui, Link, Todd M, Shah, Vrutant, Alybayev, Sanzhar, Wu, Meng-Han, Pageon, Laura R, Ma, Huaxian, Jacamo, Rodrigo, Yu, Li, Xu-Monette, Zijun Y, Steinman, Haley, Lee, Hun Ju, Sarbassov, Dos, Rapado, Inmaculada, Barton, Michelle C, Martinez-Lopez, Joaquin, Bueso-Ramos, Carlos, Young, Ken H, Post, Sean M

“…Abstract Background Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein that is aberrantly expressed in cancers. We and others have…”
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N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress by Wang, Gangduo, Wang, Jianling, Ma, Huaxian, Ansari, G.A.S., Khan, M. Firoze

“…Exposure to trichloroethene (TCE), a ubiquitous environmental contaminant, is known to induce autoimmunity both in humans and animal models. However,…”
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Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions by Carter, Bing Z, Mak, Po Yee, Tao, Wenjing, Warmoes, Mark, Lorenzi, Philip L, Mak, Duncan, Ruvolo, Vivian, Wang, Xiangmeng, Ma, Huaxian, Mu, Hong, Cidado, Justin, Drew, Lisa, Andreeff, Michael

“…Mcl-1 and Bcl-2 are two major anti-apoptotic Bcl-2 proteins frequently overexpressed in malignant cells. They cooperatively support cell survival and are…”
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Increased nitration and carbonylation of proteins in MRL +/+ mice exposed to trichloroethene: Potential role of protein oxidation in autoimmunity by Wang, Gangduo, Wang, Jianling, Ma, Huaxian, Khan, M. Firoze

“…Even though reactive oxygen and nitrogen species (RONS) are implicated as mediators of autoimmune diseases (ADs), little is known about contribution of protein…”
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Enhanced expression of cyclins and cyclin-dependent kinases in aniline-induced cell proliferation in rat spleen by Wang, Jianling, Wang, Gangduo, Ma, Huaxian, Khan, M. Firoze

“…Aniline exposure is associated with toxicity to the spleen leading to splenomegaly, hyperplasia, fibrosis and a variety of sarcomas of the spleen on chronic…”
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Oxidative DNA damage and its repair in rat spleen following subchronic exposure to aniline by Ma, Huaxian, Wang, Jianling, Abdel-Rahman, Sherif Z., Boor, Paul J., Khan, M. Firoze

“…The mechanisms by which aniline exposure elicits splenotoxic response, especially the tumorigenic response, are not well-understood. Splenotoxicity of aniline…”
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Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure by Ma, Huaxian, Wang, Jianling, Abdel-Rahman, Sherif Z., Boor, Paul J., Khan, M. Firoze

“…Mechanisms by which aniline exposure elicits splenotoxicity, especially a tumorigenic response, are not well-understood. Earlier, we have shown that aniline…”
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Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity by Ma, Huaxian, Wang, Jianling, Abdel-Rahman, Sherif Z., Hazra, Tapas K., Boor, Paul J., Khan, M. Firoze

“…The mechanisms by which aniline exposure elicits splenotoxic response, especially the tumorigenic response, are not well-understood. Earlier, we have shown…”
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Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms by Ruvolo, Peter P, Ma, Huaxian, Ruvolo, Vivian R, Zhang, Xiaorui, Mu, Hong, Schober, Wendy, Hernandez, Ivonne, Gallardo, Miguel, Khoury, Joseph D, Cortes, Jorge, Andreeff, Michael, Post, Sean M

“…Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine…”
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Differential modulation of base excision repair activities during brain ontogeny: Implications for repair of transcribed DNA by Englander, Ella W., Ma, Huaxian

“…DNA repair sustains fidelity of genomic replication in proliferating cells and integrity of transcribed sequences in postmitotic tissues. The repair process is…”
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Investigating the Impact of Smoking Traditional and E-Cigarettes on Acute Myeloid Leukemia Progression by Alqahtani, Shaikha, Figueroa, Mary, Ma, Huaxian, Chandra, Joya

“…Acute myeloid leukemia (AML) is a highly heterogeneous disease with a variable prognosis. The exact mediators of AML are not fully understood but there are…”
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Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain by Lee, Heung‐Man, Hu, Zhaoyong, Ma, Huaxian, Greeley, George H., Wang, Cheng, Englander, Ella W.

“…Mammalian cells employ a network of DNA repair pathways. DNA repair is required during development to ensure accuracy of DNA replication in the rapidly…”
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Contribution of poly(ADP-ribose)polymerase-1 activation and apoptosis in trichloroethene-mediated autoimmunity by Wang, Gangduo, Ma, Huaxian, Wang, Jianling, Khan, M. Firoze

“…Trichloroethene (TCE), a common environmental toxicant and widely used industrial solvent, has been implicated in the development of various autoimmune…”
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Inhibition of Cyclin Dependent Kinase 8(CDK8): A Novel Approach to Target the Leukemia Initiating Cells (LICs) in T-Cell Acute Lymphoblastic Leukaemia (T-ALL) by Piya, Sujan, Ma, Huaxian, Piya, Sujan, Ruvolo, Vivian, Basyal, Mahesh, Golas, Aniela, Windak, Renata, Rzymski, Tomasz, Andreeff, Michael, Borthakur, Gautam

“…Background: T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy characterized by an aberrant proliferation of immature…”
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ERK1/2 Inhibition Overcomes Resistance in Acute Myeloid Leukemia (AML) and Alters Mitochondrial Dynamics by Sharma, Priyanka, Piya, Sujan, Ma, Huaxian, Baran, Natalia, Zal, Malgorzata Anna, Hindley, Christopher J., Dao, Kim-Hien, Sims, Martin, Zal, Tomasz, Ruvolo, Vivian, Andreeff, Michael, Borthakur, Gautam

“…Background: Presence at diagnosis or acquisition of activating RAS pathway mutations is a pervasive mechanism of resistance to therapy in AML. Efforts to…”
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Inhibition of De Novo Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress by Piya, Sujan, Ma, Huaxian, Sharma, Priyanka, Kojima, Kensuke, Ruvolo, Vivian, Basyal, Mahesh, Baran, Natalia, Weetall, Marla, Sheedy, Josephine, Ray, Balmiki, Andreeff, Michael, Borthakur, Gautam

“…Background:De novo nucleotide synthesis is necessary to meet the enormous demand for nucleotides, other macromolecules associated with acute myeloid leukemia…”
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IL15 Expressing CD123-Targeted Engager T-Cell Therapy for Adult Acute Myeloid Leukemia by Mu, Hong, Ma, Huaxian, Vaidya, Abishek, Bonifant, Challice L., Gottschalk, Stephen, Velasquez, Mireya P., Andreeff, Michael

“…Background: CD123 is a potential immunotherapeutic target in AML due to its overexpression on leukemic stem cells that play an essential role in disease…”
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