Search Results - "Ma, Enlong"

Screening approach by a combination of computational and in vitro experiments: identification of fluvastatin sodium as a potential SIRT2 inhibitor by Yang, Jin, Wang, Hanxun, Liu, Jiale, Ma, Enlong, Jin, Xinxin, Li, Yanchun, Ma, Chao

“…Background Sirtuins (SIRTs) are NAD + -dependent deacetylases that play various roles in numerous pathophysiological processes, holding promise as therapeutic…”
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Nanoscale quantification of the biophysical characterization of combretastatin A-4-treated tumor cells using atomic force microscopy by Li, Yanchun, Chen, Jv, Liu, Yutong, Zhang, Weige, He, Wenhui, Xu, Hanying, Liu, Lianqing, Ma, Enlong

“…As an inhibitor of microtubule assembly, combretastatin A-4 (CA-4)-induced biological responses in tumor cells have been well known, but the corresponding…”
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JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells by Li, Yanchun, Luo, Qiyu, Yuan, Lei, Miao, Caixia, Mu, Xiaoshuo, Xiao, Wei, Li, Jianchun, Sun, Tiemin, Ma, Enlong

“…N-Benzoyl-O-(N′-(1-benzyloxycarbonyl-4-piperidiylcarbonyl) -D-phenylalanyl)-D-phenylalaninol (BBP), a novel synthesized asperphenamate derivative with the…”
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Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer by Yuan, Lei, Li, Yanchun, Zou, Chunyang, Wang, Chao, Gao, Jian, Miao, Caixia, Ma, Enlong, Sun, Tiemin

“…Three series of natural product asperphenamate derivatives with improved aqueous solubility were designed and synthesized. The in vitro anticancer activities…”
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Discovery of novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors for the efficient treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo by Li, Yanchun, Yang, Huali, Zhao, Xiangling, Zhao, Xianchen, Quan, Jishun, Wang, Lei, Ma, Enlong, Ma, Chao

“…Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a progressive fibrotic phenotype. Immunohistochemical studies on HDAC6…”
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Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis by Ma, Enlong, Chen, Ping, Wilkins, Heather M., Wang, Tao, Swerdlow, Russell H., Chen, Qi

“…An ascorbate-mediated production of oxidative stress has been shown to retard tumor growth. Subsequent glycolysis inhibition has been suggested. Here, we…”
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Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great In Vivo Efficacy in a Mouse Lung Fibrosis Model by Lei, Hongrui, Guo, Ming, Li, Xiaopeng, Jia, Fang, Li, Changtao, Yang, Yu, Cao, Meng, Jiang, Nan, Ma, Enlong, Zhai, Xin

“…Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine…”
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ASPER-29 suppresses the metastasis of pancreatic cancer cells by dual inhibition of cathepsin-L and cathepsin-S by Yuan, Lei, Zhao, Juanping, Zhao, Songkun, Dong, Tianyi, Dong, Ruitong, Liu, Dongyue, Ma, Enlong, Li, Yanchun

“…Pancreatic cancer will be the second leading cause of cancer-related mortality worldwide due to its high rate of metastasis. Cathepsins (CATs) are effectors of…”
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Riboflavin protects against pancreatic cancer metastasis by targeting TGF-β receptor 1 by Zhao, Juanping, Liu, Xiaofeng, Jin, Xinxin, Dong, Tianyi, Gao, Xiong, Wang, Jian, Li, Yanchun, Ma, Enlong

“…[Display omitted] •RF can bind to TβR1 and block TGF-β1 signaling activation in pancreatic cancer cells.•RF inhibits metastasis of pancreatic cancer cells both…”
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Glioma cell-derived placental growth factor induces regulatory B cells by Han, Song, Feng, Sizhe, Ren, Mingliang, Ma, Enlong, Wang, Xiaonan, Xu, Lunshan, Xu, Minhui

“…Tumor specific immune regulatory cells play an important role in the pathogenesis of glioma. The mechanisms have not been fully understood yet. It is suggested…”
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Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model by Lei, Hongrui, Cao, Zhi, Wu, Huinan, Li, Tong, Wang, Xinyu, Chen, Yuxiang, Ma, Enlong, Sun, Lixin, Zhai, Xin

“…In recent decades, pharmacological targeting of the autotaxin (ATX)/lysophosphatidic acid (LPA) axis accounted for excellent disease management benefits…”
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Novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors to suppress tumor metastasis and invasion in vitro and in vivo by Li, Yanchun, Quan, Jishun, Song, Haoxuan, Li, Dongzhu, Ma, Enlong, Wang, Yanjuan, Ma, Chao

“…[Display omitted] •The introduction of PBDs scaffold enriched the cap structure types of HDAC6 inhibitors.•A7 exhibited similar HDAC6 inhibitory activity than…”
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Sodium cromoglycate exerts anti-pulmonary fibrosis effects by targeting the Keap1 protein to activate Nrf2 signaling by Liu, Xiaofeng, Huang, Yuwei, Zhao, Xianchen, Guan, Yingjun, Li, Yanchun, Yuan, Lei, Wang, Chuncheng, Ma, Chao, Ma, Enlong

“…[Display omitted] •Keap1-targeting binding compounds were identified by virtual screening.•It was certified that Cro could bind to the Keap1 protein directly…”
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Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells by Huang, Haoqiang, Zhang, Yi, Xu, Xiaohong, Liu, Yongzheng, Zhao, Juanping, Ma, Lili, Lei, Jie, Ge, Wentao, Li, Ning, Ma, Enlong, Li, Yanchun, Yuan, Lei

“…[Display omitted] Currently, the migration and invasion of cancer cells remain the main factors of poor prognosis in the majority of cancer patients…”
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Overrepresentation of highly functional T regulatory cells in patients with nonfunctioning pituitary adenoma by Han, Song, Ma, Enlong, Jiang, Wei, Lu, Yu, Sun, Xiaoyu, Feng, Sizhe

“…Nonfunctioning pituitary adenoma is a common intracranial tumor. Though benign in the majority of cases, complications can be excruciating to the affected…”
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Human Glioma Cells Therapy Using ATRA-Induced Differentiation Method to Promote the Inhibitive Effect of TMZ and CCDP by Li, Xinning, Zou, Zheng, Ma, Enlong, Feng, Sizhe, Han, Song

“…The glioma stem cells (GSCs) performed the self-renewal, proliferation, and differentiation characteristics; their drug resistance has become the main reason…”
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Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells by Li, Yanchun, Zhang, Pengfei, Qiu, Feng, Chen, Lixia, Miao, Caixia, Li, Jianchun, Xiao, Wei, Ma, Enlong

“…Andrographolide, a principal diterpenoid lactone isolated from the traditional herbal medicine Andrographis paniculata, has been reported to show anti-tumor…”
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Discovery of specific HDAC6 inhibitor with anti-metastatic effects in pancreatic cancer cells through virtual screening and biological evaluation by Song, Haoxuan, Niu, Xueyan, Quan, Jishun, Li, Yanchun, Yuan, Lei, Wang, Jian, Ma, Chao, Ma, Enlong

“…[Display omitted] •HDAC6 inhibitors with diverse scaffolds were used to generate pharmacophore model.•Virtual screening combined with pharmacophore was used to…”
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Discovery of novel pyrrolo2,1-c1,4benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors for the efficient treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo by Li, Yanchun, Yang, Huali, Zhao, Xiangling, Zhao, Xianchen, Quan, Jishun, Wang, Lei, Ma, Enlong, Ma, Chao

“…Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a progressive fibrotic phenotype. Immunohistochemical studies on HDAC6…”
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A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis by Yuan, Lei, Zou, Chunyang, Ge, Wentao, Liu, Yutong, Hu, Baichun, Wang, Jian, Lin, Bin, Li, Yanchun, Ma, Enlong

“…[Display omitted] •Compound 3 showed 1.5-fold more potent activity than that of control against Cat L.•Compound 3 presented new interaction modes with…”
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