Search Results - "Ma, Brigette BY"

Population-based differences in treatment outcome following anticancer drug therapies by Ma, Brigette BY, FRACP, Hui, Edwin P, MRCP, Mok, Tony SK, Prof

“…Summary Population-based differences in toxicity and clinical outcome following treatment with anticancer drugs have an important effect on oncology practice…”
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Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways by Zhang, Jinglin, Chen, Bonan, Li, Hui, Wang, Yifei, Liu, Xiaoli, Wong, Kit Yee, Chan, Wai Nok, Chan, Aden KY, Cheung, Alvin HK, Leung, Kam Tong, Dong, Yujuan, Pan, Yi, Ke, Huixing, Liang, Li, Zhou, Zhaocai, Xiao, Jianyong, Wong, Chi Chun, Wu, William KK, Cheng, Alfred SL, Ma, Brigette BY, Yu, Jun, Lo, Kwok Wai, Kang, Wei

“…Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment exerts crucial effects in driving CRC progression…”
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Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma - clinical application of health-related quality-of-life data by Li, Leung, Mo, Frankie Kf, Chan, Stephen L, Hui, Edwin P, Tang, Nelson Sl, Koh, Jane, Leung, Linda Ks, Poon, Annette Ny, Hui, Joyce, Chu, Cheuk M, Lee, Kit F, Ma, Brigette By, Lai, Paul Bs, Chan, Anthony Tc, Yu, Simon Ch, Yeo, Winnie

“…Health-related quality-of-life (HRQOL) assessment with EORTC QLQ-C30 was prognostic for overall survival (OS) in patients with advance-stage hepatocellular…”
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Clinical outcome of neoadjuvant chemoradiation in locally advanced rectal cancer at a tertiary hospital by Yeung, W Wk, Ma, B By, Lee, J Fy, Ng, S Sm, Cheung, M Hy, Ho, W M, Tsang, M Wk, Chu, S, Lam, D Cm, Mo, F Kf

“…To review the clinical outcome of locally advanced rectal cancer treated with neoadjuvant chemoradiation followed by definitive surgery with or without…”
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Radiological, pathological and DNA remission in recurrent metastatic nasopharyngeal carcinoma by Chan, Stephen L, Hui, Edwin P, Leung, Sing F, Chan, Anthony T C, Ma, Brigette B Y

“…Circulating plasma Epstein Barr Virus DNA (EBV-DNA) is a sensitive and specific marker of nasopharyngeal carcinoma (NPC). The mainstay of treatment of…”
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Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin by Sun, Kun, Jiang, Peiyong, Cheng, Suk Hang, Cheng, Timothy H T, Wong, John, Wong, Vincent W S, Ng, Simon S M, Ma, Brigette B Y, Leung, Tak Y, Chan, Stephen L, Mok, Tony S K, Lai, Paul B S, Chan, Henry L Y, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and potential future diagnostic applications. Recent studies have shown that…”
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Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials by Chen, Yu-Pei, Tang, Ling-Long, Yang, Qi, Poh, Sharon-Shuxian, Hui, Edwin P, Chan, Anthony T C, Ong, Whee-Sze, Tan, Terence, Wee, Joseph, Li, Wen-Fei, Chen, Lei, Ma, Brigette B Y, Tong, Macy, Tan, Sze-Huey, Cheah, Shie-Lee, Fong, Kam-Weng, Sommat, Kiattisa, Soong, Yoke Lim, Guo, Ying, Lin, Ai-Hua, Sun, Ying, Hong, Ming-Huang, Cao, Su-Mei, Chen, Ming-Yuan, Ma, Jun

“…Because of the uneven geographic distribution and small number of randomized trials available, the value of additional induction chemotherapy (IC) to…”
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Systemic treatment strategies and therapeutic monitoring for advanced nasopharyngeal carcinoma by Ma, Brigette BY, Chan, Anthony TC

“…Nasopharyngeal carcinoma (NPC) is endemic in Asia and is etiologically associated with the Epstein-Barr virus. Although radiotherapy can cure most patients…”
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Characterization of rare transforming KRAS mutations in sporadic colorectal cancer by Tong, Joanna HM, Lung, Raymond WM, Sin, Frankie MC, Law, Peggy PY, Kang, Wei, Chan, Anthony WH, Ma, Brigette BY, Mak, Tony WC, Ng, Simon SM, To, Ka Fai

“…KRAS mutational status has been shown to be a predictive biomarker of resistance to anti-EGFR monoclonal antibody (mAb) therapy in patients with metastatic…”
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Clinical utility of plasma Epstein‐Barr virus DNA and ERCC1 single nucleotide polymorphism in nasopharyngeal carcinoma by Hui, Edwin P., Ma, Brigette B. Y., Chan, K. C. Allen, Chan, Charles M. L., Wong, Cesar S. C., To, Ka Fai, Chan, Anthony W. H., Tung, Stewart Y., Ng, Wai‐Tong, Cheng, Ashley C., Lee, Victor H. F., Chan, Stephen L., Loong, Herbert H. F., Kam, Michael K. M., Leung, Sing‐Fai, Ho, Rosalie, Mo, Frankie, Ngan, Roger K. C., Chan, Anthony T. C.

“…BACKGROUND Single nucleotide polymorphism (SNP) of the excision repair cross‐complementing group 1 (ERCC1) gene has been linked with sensitivity to platinum…”
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Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: Current and future directions by Ma, Brigette B. Y., Hui, Edwin P., Chan, Anthony T. C.

“…Systemic therapy is an integral part of the management of non‐keratinizing nasopharyngeal carcinoma (NPC). The purposes of this review are to provide the…”
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Colorectal cancer in Chinese patients: current and emerging treatment options by Li, Leung, Ma, Brigette By

“…Colorectal cancer is the second most common cancer in Hong Kong and its incidence is rising in economically developed Chinese cities, including Hong Kong and…”
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Abstract 3776: Examination of ERCC1 status in circulating tumor cells as a prognostic tool for patients with nasopharyngeal carcinoma by Hui, Edwin P., Ma, Brigette BY, Chan, KC Allen, Chan, Charles ML, Wong, SC Cesar, To, Ka Fai, Loong, Herbert HF, Mo, Frankie KF, Ngan, Roger KC, Chan, Anthony TC

“…Abstract Investigation of the expression pattern of DNA-repair protein excision repair cross-complementation group 1 (ERCC1) has been reported to allow…”
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An update on the safety and efficacy of regorafenib in the treatment of solid cancers by Chan, Stephen L, Ma, Brigette By

“…Regorafenib is a multi-targeted kinase inhibitor that has been approved recently for the treatment of certain gastrointestinal (GI) cancers. This review…”
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Prognostic implication of the neoadjuvant rectal score and other biomarkers of clinical outcome in Hong Kong Chinese patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiotherapy by Ho, S S K, Hon, S S F, Hung, E, Lee, J F Y, Mo, F, Tong, M, So, C, Chu, S, Ng, D C K, Lam, D, Cho, C, Mak, T W C, Ng, S S M, Futaba, K, Suen, J, To, K F, Chan, A W H, Yeung, W W K, Ma, B B Y

“…Neoadjuvant chemoradiotherapy is a standard treatment for locally advanced rectal cancer, for which pathological complete response is typically used as a…”
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Preclinical evaluation of the mTOR–PI3K inhibitor BEZ235 in nasopharyngeal cancer models by Ma, Brigette B.Y, Lui, Vivian W.Y, Hui, Connie W.C, Lau, Cecilia P.Y, Wong, Chi H, Hui, Edwin P, Ng, Margaret H.L, Cheng, Suk H, Tsao, Sai W, Tsang, Chi-Man, Cheung, Crystal S.F, Ho, Kakiu, Chan, Anthony T.C

“…Abstract The dual PI3K–mTOR inhibitor BEZ235 was evaluated in preclinical models of nasopharyngeal carcinoma (NPC). The IC50 value of BEZ235 for growth was in…”
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Targeting the polycomb repressive complex-2 related proteins with novel combinational strategies for nasopharyngeal carcinoma by Zhu, Junyu, Li, Lili, Tong, Joanna, Hui, Connie, Wong, Chi Hang, Lo, Kwok Wai, Chan, Raymond, Ai, Qi Yong, Hui, Edwin P, Chan, Anthony Tc, To, Ka F, Tao, Qian, Ma, Brigette By

“…Aberrant epigenetic regulation is critically involved in the pathogenesis of nasopharyngeal carcinoma (NPC), where abnormal histone methylation can be found in…”
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Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas by JIN, H, WANG, X, PUTTI, T. C, LUNG, M. L, SHEN, Z.-Y, XU, L.-Y, LANGFORD, C, TAO, Q, YING, J, WONG, A. H. Y, LI, H, LEE, K. Y, SRIVASTAVA, G, CHAN, A. T. C, YEO, W, MA, B. B. Y

“…Tumor suppressor genes (TSGs) often locate at chromosomal regions with frequent deletions in tumors. Loss of 16q23 occurs frequently in multiple tumors,…”
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The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines by Ma, Brigette B.Y., Sung, Fion, Tao, Qian, Poon, Fan Fong, Lui, Vivian W., Yeo, Winnie, Chan, Stephen L., Chan, Anthony T.C.

“…Summary The activity of the histone deacetylase inhibitor PXD101 was investigated in three hepatocellular carcinoma (HCC) cell lines. PXD101was found to…”
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Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response by Ma, Brigette B.Y., Lui, Vivian W.Y., Poon, Fan Fong, Wong, S.C. Cesar, To, Ka Fai, Wong, Elaine, Chen, Honglin, Lo, Kwok Wai, Tao, Qian, Chan, Anthony T.C.

“…Summary This study evaluated the preclinical activity and molecular predictors of response to gefitinib (Iressa®, Astra Zeneca Inc, UK) in nasopharyngeal…”
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