Search Results - "Ma, B By"

Population-based differences in treatment outcome following anticancer drug therapies by Ma, Brigette BY, FRACP, Hui, Edwin P, MRCP, Mok, Tony SK, Prof

“…Summary Population-based differences in toxicity and clinical outcome following treatment with anticancer drugs have an important effect on oncology practice…”
Get full text

Clinical outcome of neoadjuvant chemoradiation in locally advanced rectal cancer at a tertiary hospital by Yeung, W Wk, Ma, B By, Lee, J Fy, Ng, S Sm, Cheung, M Hy, Ho, W M, Tsang, M Wk, Chu, S, Lam, D Cm, Mo, F Kf

“…To review the clinical outcome of locally advanced rectal cancer treated with neoadjuvant chemoradiation followed by definitive surgery with or without…”
Get full text

Association of serum folate level with toxicity of capecitabine in patients with colorectal cancers: a prospective cohort study by Chan, S L, Ma, B By, Chan, A Kc

Get full text

Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways by Zhang, Jinglin, Chen, Bonan, Li, Hui, Wang, Yifei, Liu, Xiaoli, Wong, Kit Yee, Chan, Wai Nok, Chan, Aden KY, Cheung, Alvin HK, Leung, Kam Tong, Dong, Yujuan, Pan, Yi, Ke, Huixing, Liang, Li, Zhou, Zhaocai, Xiao, Jianyong, Wong, Chi Chun, Wu, William KK, Cheng, Alfred SL, Ma, Brigette BY, Yu, Jun, Lo, Kwok Wai, Kang, Wei

“…Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment exerts crucial effects in driving CRC progression…”
Get full text

Is allostery an intrinsic property of all dynamic proteins? by Gunasekaran, K., Ma, Buyong, Nussinov, Ruth

“…Allostery involves coupling of conformational changes between two widely separated binding sites. The common view holds that allosteric proteins are symmetric…”
Get full text

Hot Regions in Protein–Protein Interactions: The Organization and Contribution of Structurally Conserved Hot Spot Residues by Keskin, Ozlem, Ma, Buyong, Nussinov, Ruth

“…Structurally conserved residues at protein–protein interfaces correlate with the experimental alanine-scanning hot spots. Here, we investigate the organization…”
Get full text

Principles of docking: An overview of search algorithms and a guide to scoring functions by Halperin, Inbal, Ma, Buyong, Wolfson, Haim, Nussinov, Ruth

“…The docking field has come of age. The time is ripe to present the principles of docking, reviewing the current state of the field. Two reasons are largely…”
Get full text

Protein-Protein Interactions: Structurally Conserved Residues Distinguish between Binding Sites and Exposed Protein Surfaces by Ma, Buyong, Elkayam, Tal, Wolfson, Haim, Nussinov, Ruth

“…Polar residue hot spots have been observed at protein-protein binding sites. Here we show that hot spots occur predominantly at the interfaces of…”
Get full text

Molecular dynamics simulations of alanine rich β‐sheet oligomers: Insight into amyloid formation by Ma, Buyong, Nussinov, Ruth

“…The aggregation observed in protein conformational diseases is the outcome of significant new β‐sheet structure not present in the native state. Peptide model…”
Get full text

Systemic treatment strategies and therapeutic monitoring for advanced nasopharyngeal carcinoma by Ma, Brigette BY, Chan, Anthony TC

“…Nasopharyngeal carcinoma (NPC) is endemic in Asia and is etiologically associated with the Epstein-Barr virus. Although radiotherapy can cure most patients…”
Get full text

Protein–Protein Interactions: Hot Spots and Structurally Conserved Residues often Locate in Complemented Pockets that Pre-organized in the Unbound States: Implications for Docking by Li, Xiang, Keskin, Ozlem, Ma, Buyong, Nussinov, Ruth, Liang, Jie

“…Energetic hot spots account for a significant portion of the total binding free energy and correlate with structurally conserved interface residues. Here, we…”
Get full text

Multiple diverse ligands binding at a single protein site: A matter of pre‐existing populations by Ma, Buyong, Shatsky, Maxim, Wolfson, Haim J., Nussinov, Ruth

“…Here, we comment on the steadily increasing body of data showing that proteins with specificity actually bind ligands of diverse shapes, sizes, and…”
Get full text

Bone marrow-derived cells as progenitors of lung alveolar epithelium by Kotton, D N, Ma, B Y, Cardoso, W V, Sanderson, E A, Summer, R S, Williams, M C, Fine, A

“…We assessed the capacity of plastic-adherent cultured bone marrow cells to serve as precursors of differentiated parenchymal cells of the lung. By…”
Get full text

The Stability of Monomeric Intermediates Controls Amyloid Formation: A beta 25-35 and its N27Q Mutant by Ma, B, Nussinov, R

“…The structure and stabilities of the intermediates affect protein folding as well as misfolding and amyloid formation. By applying Kramer's theory of barrier…”
Get full text

Radiological, pathological and DNA remission in recurrent metastatic nasopharyngeal carcinoma by Chan, Stephen L, Hui, Edwin P, Leung, Sing F, Chan, Anthony T C, Ma, Brigette B Y

“…Circulating plasma Epstein Barr Virus DNA (EBV-DNA) is a sensitive and specific marker of nasopharyngeal carcinoma (NPC). The mainstay of treatment of…”
Get full text

Short Peptide Amyloid Organization: Stabilities and Conformations of the Islet Amyloid Peptide NFGAIL by Zanuy, David, Ma, Buyong, Nussinov, Ruth

“…Experimentally, short peptides have been shown to form amyloids similar to those of their parent proteins. Consequently, they present useful systems for…”
Get full text

Folding and binding cascades: Dynamic landscapes and population shifts by KUMAR, SANDEEP, MA, BUYONG, TSAI, CHUNG-JUNG, SINHA, NEETI, NUSSINOV, RUTH

“…Whereas previously we have successfully utilized the folding funnels concept to rationalize binding mechanisms (Ma B, Kumar S, Tsai CJ, Nussinov R, 1999,…”
Get full text

Folding funnels and binding mechanisms by Ma, Buyong, Kumar, Sandeep, Tsai, Chung-Jung, Nussinov, Ruth

“…The long-held views on lock-and-key versus induced fit in binding arose from the notion that a protein exists in a single, most stable conformation, dictated…”
Get full text

Folding funnels, binding funnels, and protein function by TSAI, CHUNG-JUNG, KUMAR, SANDEEP, MA, BUYONG, NUSSINOV, RUTH

“…Folding funnels have been the focus of considerable attention during the last few years. These have mostly been discussed in the general context of the theory…”
Get full text

Folding and Binding Cascades: Shifts in Energy Landscapes by Tsai, Chung-Jung, Ma, Buyong, Nussinov, Ruth

“…The funnel shape energy landscape theory has been successfully used to describe the folding and binding behavior in proteins. Tsai et al describe a shift in…”
Get full text