Search Results - "Ma, Alvin C.H"

TALEN-Mediated Mutagenesis and Genome Editing by Ma, Alvin C H, Chen, Yi, Blackburn, Patrick R, Ekker, Stephen C

“…Transcription activator-like effectors (TALEs) are important genomic tools with customizable DNA-binding motifs for locus-specific modifications. In…”
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A Zebrafish Model for Evaluating the Function of Human Leukemic Gene IDH1 and Its Mutation by Ma, Alvin C H, Shi, Xiangguo, He, Bai-Liang, Guo, Yuhan, Leung, Anskar Y H

“…The recent advent of next-generation sequencing (NGS) has greatly accelerated identification of gene mutations in myeloid malignancies at unprecedented speed…”
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Fishing the targets of myeloid malignancies in the era of next generation sequencing by Shi, Xiangguo, He, Bai-Liang, Ma, Alvin C.H, Leung, Anskar Y.H

“…Abstract Recent advent in next generation sequencing (NGS) and bioinformatics has generated an unprecedented amount of genetic information in myeloid…”
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Declined presentation by Shi, Xiangguo, Guo, Yuhan, He, Bailiang, Ma, Alvin C.H, Leung, Anskar Y.H

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A zebrafish model of FMS-like tyrosine kinase 3 (FLT3) in definitive hematopoiesis and human acute myeloid leukemia by He, Bailiang, Man, Cheuk Him, Shi, Xiangguo, Ma, Alvin C.H, Leung, Anskar Y.H

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The role of inka1b in zebrafish primitive hematopoiesis by Shi, Xiangguo, He, Bailiang, Guo, Yuhan, Ma, Alvin C.H, Wong, Natalie S.M, Leung, Anskar Y.H

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The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development by Ma, Alvin C.H, Liang, Raymond, Leung, Anskar Y.H

“…Objectives Phospholipase C (PLC) gamma 1 has been shown to mediate signal transduction of tyrosine kinases and affect function of hematopoietic cells. However,…”
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A novel zebrafish jak2aV581F model shared features of human JAK2V617F polycythemia vera by Ma, Alvin C.H, Fan, August, Ward, Alister C, Liongue, Clifford, Lewis, Rowena S, Cheng, Suk H, Chan, P.K, Yip, Sze-Fai, Liang, Raymond, Leung, Anskar Y.H

“…Objective The Janus kinase 2 (JAK2) is important for embryonic primitive hematopoiesis. A gain-of-function JAK2 ( JAK2V617F ) mutation in human is…”
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Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation by Man, Cheuk Him, Fung, Tsz Kan, Ho, Christa, Han, Heron H.C., Chow, Howard C.H., Ma, Alvin C.H., Choi, William W.L., Lok, Si, Cheung, Alice M.S., Eaves, Connie, Kwong, Yok Lam, Leung, Anskar Y.H.

“…Internal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% of acute myeloid leukemias (AMLs) and confers a poor…”
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Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia by He, Bai-Liang, Shi, Xiangguo, Man, Cheuk Him, Ma, Alvin C.H., Ekker, Stephen C., Chow, Howard C.H., So, Chi Wai Eric, Choi, William W.L., Zhang, Wenqing, Zhang, Yiyue, Leung, Anskar Y.H.

“…FMS-like tyrosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its role during embryogenesis is unclear. In acute…”
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Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish by Shi, Xiangguo, He, Bai-Liang, Ma, Alvin C.H., Guo, Yuhan, Chi, Yali, Man, Cheuk Him, Zhang, Wenqing, Zhang, Yiyue, Wen, Zilong, Cheng, Tao, Leung, Anskar Y.H.

“…Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to…”
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Metformin accelerates zebrafish heart regeneration by inducing autophagy by Xie, Fangjing, Xu, Shisan, Lu, Yingying, Wong, Kin Fung, Sun, Lei, Hasan, Kazi Md Mahmudul, Ma, Alvin C. H., Tse, Gary, Manno, Sinai H. C., Tian, Li, Yue, Jianbo, Cheng, Shuk Han

“…Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism…”
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Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies by Leung, Gordon K. C., Luk, H. M., Tang, Vincent H. M., Gao, W. W., Mak, Christopher C. Y., Yu, Mullin H. C., Wong, W. L., Chu, Yoyo W. Y., Yang, W. L., Wong, Wilfred H. S., Ma, Alvin C. H., Leung, Anskar Y. H., Jin, D. Y., Chan, Kelvin Y. K., Allanson, Judith, Lo, Ivan F. M., Chung, Brian H. Y.

“…RASopathies are a group of heterogeneous conditions caused by germline mutations in RAS/MAPK signalling pathway genes. With next-generation sequencing (NGS),…”
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Declined presentation: Expression of zebrafish idh1r146h causes expanded myelopoiesis in zebrafish by Shi, Xiangguo, Guo, Yuhan, He, Bailiang, Ma, Alvin C.H., Leung, Anskar Y.H.

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Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium by Guo, Yuhan, Cheng, Bowie Y.L., Wang, Dandan, Ma, Alvin C.H., He, Bai-Liang, Man, Toni K., Cheung, May P.L., Shi, Xiangguo, Ng, Nelson K.L., Leung, Anskar Y.H.

“…ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. It is expressed in hematopoietic tissue during embryonic…”
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The role of jak2a in zebrafish hematopoiesis by Ma, Alvin C.H., Ward, Alister C., Liang, Raymond, Leung, Anskar Y.H.

“…Janus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation (Jak2617V>F) is associated with myeloproliferative…”
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Methionine aminopeptidase 2 is required for HSC initiation and proliferation by Ma, Alvin C.H., Fung, Tsz K., Lin, Rachel H.C., Chung, Martin I.S., Yang, Dan, Ekker, Stephen C., Leung, Anskar Y.H.

“…In a chemical screening, we tested the antiangiogenic effects of fumagillin derivatives and identified fumagillin as an inhibitor of definitive hematopoiesis…”
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A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera by Ma, Alvin C H, Fan, August, Ward, Alister C, Liongue, Clifford, Lewis, Rowena S, Cheng, Suk H, Chan, P K, Yip, Sze-Fai, Liang, Raymond, Leung, Anskar Y H

“…The Janus kinase 2 (JAK2) is important for embryonic primitive hematopoiesis. A gain-of-function JAK2 (JAK2(V617F)) mutation in human is pathogenetically…”
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The Role of Survivin in Angiogenesis during Zebrafish Embryonic Development by Leung, Anskar Y.H., Ma, Alvin C.H., Meng, Anming, Verfaillie, Catherine M., Liang, Raymond

“…We investigated the role of survivin in angiogenesis during zebrafish development. Morpholinos (MOs) targeting the 5′ untranslated region (UTR) (SurUTR) and…”
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A novel zebrafish jak2a V581F model shared features of human JAK2 V617F polycythemia vera by Ma, Alvin C.H., Fan, August, Ward, Alister C., Liongue, Clifford, Lewis, Rowena S., Cheng, Suk H., Chan, P.K., Yip, Sze-Fai, Liang, Raymond, Leung, Anskar Y.H.

“…The Janus kinase 2 (JAK2) is important for embryonic primitive hematopoiesis. A gain-of-function JAK2 ( JAK2 V617F ) mutation in human is pathogenetically…”
Get full text