Search Results - "Ma, Alvin C."

Robust activation of microhomology-mediated end joining for precision gene editing applications by Ata, Hirotaka, Ekstrom, Thomas L, Martínez-Gálvez, Gabriel, Mann, Carla M, Dvornikov, Alexey V, Schaefbauer, Kyle J, Ma, Alvin C, Dobbs, Drena, Clark, Karl J, Ekker, Stephen C

“…One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This…”
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Mojo Hand, a TALEN design tool for genome editing applications by Neff, Kevin L, Argue, David P, Ma, Alvin C, Lee, Han B, Clark, Karl J, Ekker, Stephen C

“…Recent studies of transcription activator-like (TAL) effector domains fused to nucleases (TALENs) demonstrate enormous potential for genome editing. Effective…”
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High efficiency In Vivo genome engineering with a simplified 15-RVD GoldyTALEN design by Ma, Alvin C, Lee, Han B, Clark, Karl J, Ekker, Stephen C

“…Transcription activator-like effector nucleases (TALENs) enable genome engineering in cell culture and many organisms. Recently, the GoldyTALEN scaffold was…”
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FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science by Ma, Alvin C, McNulty, Melissa S, Poshusta, Tanya L, Campbell, Jarryd M, Martínez-Gálvez, Gabriel, Argue, David P, Lee, Han B, Urban, Mark D, Bullard, Cassandra E, Blackburn, Patrick R, Man, Toni K, Clark, Karl J, Ekker, Stephen C

“…Transcription activator-like effectors (TALEs) are extremely effective, single-molecule DNA-targeting molecular cursors used for locus-specific genome science…”
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Metformin accelerates zebrafish heart regeneration by inducing autophagy by Xie, Fangjing, Xu, Shisan, Lu, Yingying, Wong, Kin Fung, Sun, Lei, Hasan, Kazi Md Mahmudul, Ma, Alvin C. H., Tse, Gary, Manno, Sinai H. C., Tian, Li, Yue, Jianbo, Cheng, Shuk Han

“…Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism…”
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Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation by Man, Cheuk Him, Fung, Tsz Kan, Ho, Christa, Han, Heron H.C., Chow, Howard C.H., Ma, Alvin C.H., Choi, William W.L., Lok, Si, Cheung, Alice M.S., Eaves, Connie, Kwong, Yok Lam, Leung, Anskar Y.H.

“…Internal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% of acute myeloid leukemias (AMLs) and confers a poor…”
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The role of jak2a in zebrafish hematopoiesis by Ma, Alvin C.H., Ward, Alister C., Liang, Raymond, Leung, Anskar Y.H.

“…Janus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation (Jak2617V>F) is associated with myeloproliferative…”
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Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies by Leung, Gordon K. C., Luk, H. M., Tang, Vincent H. M., Gao, W. W., Mak, Christopher C. Y., Yu, Mullin H. C., Wong, W. L., Chu, Yoyo W. Y., Yang, W. L., Wong, Wilfred H. S., Ma, Alvin C. H., Leung, Anskar Y. H., Jin, D. Y., Chan, Kelvin Y. K., Allanson, Judith, Lo, Ivan F. M., Chung, Brian H. Y.

“…RASopathies are a group of heterogeneous conditions caused by germline mutations in RAS/MAPK signalling pathway genes. With next-generation sequencing (NGS),…”
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Methionine aminopeptidase 2 is required for HSC initiation and proliferation by Ma, Alvin C.H., Fung, Tsz K., Lin, Rachel H.C., Chung, Martin I.S., Yang, Dan, Ekker, Stephen C., Leung, Anskar Y.H.

“…In a chemical screening, we tested the antiangiogenic effects of fumagillin derivatives and identified fumagillin as an inhibitor of definitive hematopoiesis…”
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TALEN-Mediated Mutagenesis and Genome Editing by Ma, Alvin C H, Chen, Yi, Blackburn, Patrick R, Ekker, Stephen C

“…Transcription activator-like effectors (TALEs) are important genomic tools with customizable DNA-binding motifs for locus-specific modifications. In…”
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Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia by He, Bai-Liang, Shi, Xiangguo, Man, Cheuk Him, Ma, Alvin C.H., Ekker, Stephen C., Chow, Howard C.H., So, Chi Wai Eric, Choi, William W.L., Zhang, Wenqing, Zhang, Yiyue, Leung, Anskar Y.H.

“…FMS-like tyrosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its role during embryogenesis is unclear. In acute…”
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In vivo genome editing using a high-efficiency TALEN system by Bedell, Victoria M., Wang, Ying, Campbell, Jarryd M., Poshusta, Tanya L., Starker, Colby G., Krug II, Randall G., Tan, Wenfang, Penheiter, Sumedha G., Ma, Alvin C., Leung, Anskar Y. H., Fahrenkrug, Scott C., Carlson, Daniel F., Voytas, Daniel F., Clark, Karl J., Essner, Jeffrey J., Ekker, Stephen C.

“…Although zebrafish is an important animal model for basic vertebrate biology and human disease modelling, rapid targeted genome modification has not been…”
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Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish by Shi, Xiangguo, He, Bai-Liang, Ma, Alvin C.H., Guo, Yuhan, Chi, Yali, Man, Cheuk Him, Zhang, Wenqing, Zhang, Yiyue, Wen, Zilong, Cheng, Tao, Leung, Anskar Y.H.

“…Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to…”
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A Zebrafish Model for Evaluating the Function of Human Leukemic Gene IDH1 and Its Mutation by Ma, Alvin C H, Shi, Xiangguo, He, Bai-Liang, Guo, Yuhan, Leung, Anskar Y H

“…The recent advent of next-generation sequencing (NGS) has greatly accelerated identification of gene mutations in myeloid malignancies at unprecedented speed…”
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TGF-β induced senescence is a novel therapeutic target for treating osteoporosis in Gerodermia Osteodysplastica by Chan, Wing Lee, Goldes, Jonathan, Steiner, Magdalena, Ma, Alvin C., Mundlos, Stefan, Kornak, Uwe

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Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium by Guo, Yuhan, Cheng, Bowie Y.L., Wang, Dandan, Ma, Alvin C.H., He, Bai-Liang, Man, Toni K., Cheung, May P.L., Shi, Xiangguo, Ng, Nelson K.L., Leung, Anskar Y.H.

“…ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. It is expressed in hematopoietic tissue during embryonic…”
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Fishing the targets of myeloid malignancies in the era of next generation sequencing by Shi, Xiangguo, He, Bai-Liang, Ma, Alvin C.H, Leung, Anskar Y.H

“…Abstract Recent advent in next generation sequencing (NGS) and bioinformatics has generated an unprecedented amount of genetic information in myeloid…”
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A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera by Ma, Alvin C H, Fan, August, Ward, Alister C, Liongue, Clifford, Lewis, Rowena S, Cheng, Suk H, Chan, P K, Yip, Sze-Fai, Liang, Raymond, Leung, Anskar Y H

“…The Janus kinase 2 (JAK2) is important for embryonic primitive hematopoiesis. A gain-of-function JAK2 (JAK2(V617F)) mutation in human is pathogenetically…”
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The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development by Ma, Alvin C.H, Liang, Raymond, Leung, Anskar Y.H

“…Objectives Phospholipase C (PLC) gamma 1 has been shown to mediate signal transduction of tyrosine kinases and affect function of hematopoietic cells. However,…”
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In vivo Genome Editing Using High Efficiency TALENs by Bedell, Victoria M., Wang, Ying, Campbell, Jarryd M., Poshusta, Tanya L., Starker, Colby G., Krug, Randall G., Tan, Wenfang, Penheiter, Sumedha G., Ma, Alvin C., Leung, Anskar Y.H., Fahrenkrug, Scott C., Carlson, Daniel F., Voytas, Daniel F., Clark, Karl J., Essner, Jeffrey J., Ekker, Stephen C.

“…The zebrafish ( Danio rerio ) is increasingly being used to study basic vertebrate biology and human disease using a rich array of in vivo genetic and…”
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